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Cell heterogeneity and the inherent complexity due to the interplay of multiple molecular processes within the cell pose difficult challenges for current single-cell biology. We introduce an approach that identifies a disease phenotype from…

In this paper, we introduce a new dataset, \textbf{Kimia Path24}, for image classification and retrieval in digital pathology. We use the whole scan images of 24 different tissue textures to generate 1,325 test patches of size…

Computer Vision and Pattern Recognition · Computer Science 2017-05-23 Morteza Babaie , Shivam Kalra , Aditya Sriram , Christopher Mitcheltree , Shujin Zhu , Amin Khatami , Shahryar Rahnamayan , H. R. Tizhoosh

We present a method for automatic cell classification in tissue samples using an automated training set from multiplexed immunofluorescence images. The method utilizes multiple markers stained in situ on a single tissue section on a robust…

Image and Video Processing · Electrical Eng. & Systems 2020-07-21 Alberto Santamaria-Pang , Anup Sood , Dan Meyer , Aritra Chowdhury , Fiona Ginty

Research increasingly relies on computational methods to analyze experimental data and predict molecular properties. Current approaches often require researchers to use a variety of tools for statistical analysis and machine learning,…

Quantitative Methods · Quantitative Biology 2025-12-01 Luke Rimmo Lego , Samantha Gauthier , Denver Jn. Baptiste

Identification of plant disease is usually done through visual inspection or during laboratory examination which causes delays resulting in yield loss by the time identification is complete. On the other hand, complex deep learning models…

Computer Vision and Pattern Recognition · Computer Science 2021-02-10 Nisar Ahmed , Hafiz Muhammad Shahzad Asif , Gulshan Saleem

The Ki-67 proliferation index is an essential biomarker that helps pathologists to diagnose and select appropriate treatments. However, automatic evaluation of Ki-67 is difficult due to nuclei overlapping and complex variations in their…

Image and Video Processing · Electrical Eng. & Systems 2022-03-16 Khaled Benaggoune , Zeina Al Masry , Jian Ma , Christine Devalland , L. H Mouss , Noureddine Zerhouni

Network inference has been attracting increasing attention in several fields, notably systems biology, control engineering and biomedicine. To develop a therapy, it is essential to understand the connectivity of biochemical units and the…

Systems and Control · Electrical Eng. & Systems 2024-12-20 Junyang Jin , Ye Yuan , Jorge Goncalves

With the development of digital imaging in medical microscopy, artificial intelligent-based analysis of pathological whole slide images (WSIs) provides a powerful tool for cancer diagnosis. Limited by the expensive cost of pixel-level…

Computer Vision and Pattern Recognition · Computer Science 2024-11-19 Jiawen Li , Qiehe Sun , Renao Yan , Yizhi Wang , Yuqiu Fu , Yani Wei , Tian Guan , Huijuan Shi , Yonghonghe He , Anjia Han

With the advancement of high-throughput biotechnologies, we increasingly accumulate biomedical data about diseases, especially cancer. There is a need for computational models and methods to sift through, integrate, and extract new…

Quantitative Methods · Quantitative Biology 2020-07-03 Thomas Gaudelet , Noel Malod-Dognin , Natasa Przulj

Change-point detection has garnered significant attention due to its broad range of applications, including epidemic disease outbreaks, social network evolution, image analysis, and wireless communications. In an online setting, where new…

Machine Learning · Statistics 2024-08-26 Zihan Wang

As both computer vision models and biomedical datasets grow in size, there is an increasing need for efficient inference algorithms. We utilize cascade detectors to efficiently identify sparse objects in multiresolution images. Given an…

Computer Vision and Pattern Recognition · Computer Science 2025-05-01 Thomas L. Athey , Shashata Sawmya , Nir Shavit

In recent years, the field of single-cell data analysis has seen a marked advancement in the development of clustering methods. Despite advancements, most of these algorithms still concentrate on analyzing the provided single-cell matrix…

Machine Learning · Computer Science 2023-12-18 Dayu Hu , Ke Liang , Hao Yu , Xinwang Liu

We propose a novel "tree-averaging" model that utilizes the ensemble of classification and regression trees (CART). Each constituent tree is estimated with a subset of similar data. We treat this grouping of subsets as Bayesian ensemble…

Machine Learning · Statistics 2014-08-20 Leo L. Duan , John P. Clancy , Rhonda D. Szczesniak

Major advances have been made regarding the utilization of artificial intelligence in health care. In particular, deep learning approaches have been successfully applied for automated and assisted disease diagnosis and prognosis based on…

Methodology · Statistics 2020-03-24 Max Westphal , Antonia Zapf , Werner Brannath

With the rapid development of computational pathology, many AI-assisted diagnostic tasks have emerged. Cellular nuclei segmentation can segment various types of cells for downstream analysis, but it relies on predefined categories and lacks…

Computer Vision and Pattern Recognition · Computer Science 2025-03-03 Chunlin Zhong , Shuang Hao , Junhua Wu , Xiaona Chang , Jiwei Jiang , Xiu Nie , He Tang , Xiang Bai

We consider the problem of landmark matching between two unlabelled point sets, in particular where the number of points in each cloud may differ, and where points in each cloud may not have a corresponding match. We invoke a Bayesian…

Methodology · Statistics 2022-06-01 Jessica E. Forsyth , Ali H. Al-Anbaki , Berenika Plusa , Simon L. Cotter

We share our recent findings in an attempt to train a universal segmentation network for various cell types and imaging modalities. Our method was built on the generalized U-Net architecture, which allows the evaluation of each component…

Computer Vision and Pattern Recognition · Computer Science 2022-08-01 Tianqi Guo , Yin Wang , Luis Solorio , Jan P. Allebach

Computer-aided detection (CADe) of early neoplasia in Barrett's esophagus is a low-prevalence surveillance problem in which clinically relevant findings are rare. Although many CADe systems report strong performance on balanced or enriched…

We introduce a new table detection and structure recognition approach named RobusTabNet to detect the boundaries of tables and reconstruct the cellular structure of each table from heterogeneous document images. For table detection, we…

Computer Vision and Pattern Recognition · Computer Science 2022-09-19 Chixiang Ma , Weihong Lin , Lei Sun , Qiang Huo

Mitosis detection is one of the fundamental tasks in computational pathology, which is extremely challenging due to the heterogeneity of mitotic cell. Most of the current studies solve the heterogeneity in the technical aspect by increasing…

Computer Vision and Pattern Recognition · Computer Science 2023-07-13 Hao Wang , Jiatai Lin , Danyi Li , Jing Wang , Bingchao Zhao , Zhenwei Shi , Xipeng Pan , Huadeng Wang , Bingbing Li , Changhong Liang , Guoqiang Han , Li Liang , Chu Han , Zaiyi Liu