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This paper explores the use of large language models (LLMs) to assist in the development of new disease modules for Synthea, an open-source synthetic health data generator. Incorporating LLMs into the module development process has the…

Artificial Intelligence · Computer Science 2025-07-30 Mark A. Kramer , Aanchal Mathur , Caroline E. Adams , Jason A. Walonoski

Medical artificial intelligence systems have achieved remarkable diagnostic capabilities, yet they consistently exhibit performance disparities across demographic groups, causing real-world harm to underrepresented populations. While recent…

Machine Learning · Computer Science 2025-10-24 Shiqi Dai , Wei Dai , Jiaee Cheong , Paul Pu Liang

Analyzing medical data to find abnormalities is a time-consuming and costly task, particularly for rare abnormalities, requiring tremendous efforts from medical experts. Artificial intelligence has become a popular tool for the automatic…

Clinical data usually cannot be freely distributed due to their highly confidential nature and this hampers the development of machine learning in the healthcare domain. One way to mitigate this problem is by generating realistic synthetic…

AI requires extensive datasets, while medical data is subject to high data protection. Anonymization is essential, but poses a challenge for some regions, such as the head, as identifying structures overlap with regions of clinical…

While hundreds of artificial intelligence (AI) algorithms are now approved or cleared by the US Food and Drugs Administration (FDA), many studies have shown inconsistent generalization or latent bias, particularly for underrepresented…

Computer Vision and Pattern Recognition · Computer Science 2023-08-25 Luke W. Sagers , James A. Diao , Luke Melas-Kyriazi , Matthew Groh , Pranav Rajpurkar , Adewole S. Adamson , Veronica Rotemberg , Roxana Daneshjou , Arjun K. Manrai

Despite the rapid growth in model architecture, the scarcity of large parallel corpora remains the main bottleneck in Neural Machine Translation. Data augmentation is a technique that enhances the performance of data-hungry models by…

Computation and Language · Computer Science 2023-11-14 Seokjin Oh , Su Ah Lee , Woohwan Jung

This study investigates the possibility of mitigating the demographic biases that affect face recognition technologies through the use of synthetic data. Demographic biases have the potential to impact individuals from specific demographic…

Computer Vision and Pattern Recognition · Computer Science 2024-02-05 Pietro Melzi , Christian Rathgeb , Ruben Tolosana , Ruben Vera-Rodriguez , Aythami Morales , Dominik Lawatsch , Florian Domin , Maxim Schaubert

Access to electronic health records (EHRs) for digital health research is often limited by privacy regulations and institutional barriers. Synthetic EHRs have been proposed as a way to enable safe and sovereign data sharing; however,…

Machine Learning · Computer Science 2026-03-10 Guanglin Zhou , Armin Catic , Motahare Shabestari , Matthew Young , Chaiquan Li , Katrina Poppe , Sebastiano Barbieri

Since technology is advancing so quickly in the modern era of information, data is becoming an essential resource in many fields. Correct data collection, organization, and analysis make it a potent tool for successful decision-making,…

Machine Learning · Computer Science 2024-05-28 Dilsat Berin Aytar , Semra Gunduc

Imbalanced classification often causes standard training procedures to prioritize the majority class and perform poorly on rare but important cases. A classic and widely used remedy is to augment the minority class with synthetic samples,…

Machine Learning · Statistics 2026-03-10 Zhengchi Ma , Anru R. Zhang

As LLMs (large language models) are increasingly used to generate synthetic personas particularly in data-limited domains such as health, privacy, and HCI, it becomes necessary to understand how these narratives represent identity,…

Computation and Language · Computer Science 2025-05-14 Pranav Narayanan Venkit , Jiayi Li , Yingfan Zhou , Sarah Rajtmajer , Shomir Wilson

Synthetic data augmentation helps language models learn new knowledge in data-constrained domains. However, naively scaling existing synthetic data methods by training on more synthetic tokens or using stronger generators yields diminishing…

Machine Learning · Computer Science 2026-03-31 Seungju Han , Konwoo Kim , Chanwoo Park , Benjamin Newman , Suhas Kotha , Jaehun Jung , James Zou , Yejin Choi

Synthetic data serves as an alternative in training machine learning models, particularly when real-world data is limited or inaccessible. However, ensuring that synthetic data mirrors the complex nuances of real-world data is a challenging…

Machine Learning · Computer Science 2023-10-27 Lasse Hansen , Nabeel Seedat , Mihaela van der Schaar , Andrija Petrovic

Social biases in LLMs are usually measured via bias benchmark datasets. Current benchmarks have limitations in scope, grounding, quality, and human effort required. Previous work has shown success with a community-sourced, rather than…

Computation and Language · Computer Science 2024-05-27 Virginia K. Felkner , Jennifer A. Thompson , Jonathan May

In the field of healthcare, electronic health records (EHR) serve as crucial training data for developing machine learning models for diagnosis, treatment, and the management of healthcare resources. However, medical datasets are often…

Machine Learning · Statistics 2024-03-21 Keira Behal , Jiayi Chen , Caleb Fikes , Sophia Xiao

The present study aimed to address the issue of imbalanced data in classification tasks and evaluated the suitability of SMOTE, ADASYN, and GAN techniques in generating synthetic data to address the class imbalance and improve the…

Machine Learning · Computer Science 2023-06-27 Nagarjuna Chereddy , Bharath Kumar Bolla

Synthetic data has been proposed as a solution to address the issue of high-quality data scarcity in the training of large language models (LLMs). Studies have shown that synthetic data can effectively improve the performance of LLMs on…

Computation and Language · Computer Science 2024-06-19 Jie Chen , Yupeng Zhang , Bingning Wang , Wayne Xin Zhao , Ji-Rong Wen , Weipeng Chen

While synthetic data hold great promise for privacy protection, their statistical analysis poses significant challenges that necessitate innovative solutions. The use of deep generative models (DGMs) for synthetic data generation is known…

Generating synthetic text addresses the challenge of data availability in privacy-sensitive domains such as healthcare. This study explores the applicability of synthetic data in real-world medical settings. We introduce MedSyn, a novel…

Computation and Language · Computer Science 2024-09-05 Gleb Kumichev , Pavel Blinov , Yulia Kuzkina , Vasily Goncharov , Galina Zubkova , Nikolai Zenovkin , Aleksei Goncharov , Andrey Savchenko