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Ensuring the generalisability of clinical machine learning (ML) models across diverse healthcare settings remains a significant challenge due to variability in patient demographics, disease prevalence, and institutional practices. Existing…

Machine Learning · Computer Science 2025-04-30 Bradley Segal , Joshua Fieggen , David Clifton , Lei Clifton

Machine learning (ML) holds great promise for clinical applications but is often hindered by limited access to high-quality data due to privacy concerns, high costs, and long timelines associated with clinical trials. While large language…

Computation and Language · Computer Science 2026-03-27 Zerui Xu , Fang Wu , Yingzhou Lu , Yuanyuan Zhang , Yue Zhao

Recently, GPT-4o has garnered significant attention for its strong performance in image generation, yet open-source models still lag behind. Several studies have explored distilling image data from GPT-4o to enhance open-source models,…

Computer Vision and Pattern Recognition · Computer Science 2025-08-14 Junyan Ye , Dongzhi Jiang , Zihao Wang , Leqi Zhu , Zhenghao Hu , Zilong Huang , Jun He , Zhiyuan Yan , Jinghua Yu , Hongsheng Li , Conghui He , Weijia Li

The recent surge in research focused on generating synthetic data from large language models (LLMs), especially for scenarios with limited data availability, marks a notable shift in Generative Artificial Intelligence (AI). Their ability to…

Machine Learning · Computer Science 2024-03-08 Xu Guo , Yiqiang Chen

Synthetic tabular data generation has emerged as a promising method to address limited data availability and privacy concerns. With the sharp increase in the performance of large language models in recent years, researchers have been…

Machine Learning · Computer Science 2025-03-28 Reilly Cannon , Nicolette M. Laird , Caesar Vazquez , Andy Lin , Amy Wagler , Tony Chiang

While tabular data is fundamental to many real-world machine learning (ML) applications, acquiring high-quality tabular data is usually labor-intensive and expensive. Limited by the scarcity of observations, tabular datasets often exhibit…

Machine Learning · Computer Science 2026-02-05 Congjing Zhang , Ryan Feng Lin , Ruoxuan Bao , Shuai Huang

Large Language Models (LLMs) like GPT-4o can help automate text classification tasks at low cost and scale. However, there are major concerns about the validity and reliability of LLM outputs. By contrast, human coding is generally more…

Computation and Language · Computer Science 2025-01-17 Conrad Borchers , Danielle R. Thomas , Jionghao Lin , Ralph Abboud , Kenneth R. Koedinger

Synthetic data generation using large language models (LLMs) demonstrates substantial promise in addressing biomedical data challenges and shows increasing adoption in biomedical research. This study systematically reviews recent advances…

Computation and Language · Computer Science 2026-02-18 Hanshu Rao , Weisi Liu , Haohan Wang , I-Chan Huang , Zhe He , Xiaolei Huang

We propose a new framework for zero-shot generation of synthetic tabular data. Using the large language model (LLM) GPT-4o and plain-language prompting, we demonstrate the ability to generate high-fidelity tabular data without task-specific…

Machine Learning · Computer Science 2025-02-21 Austin A. Barr , Robert Rozman , Eddie Guo

The widespread adoption of synthetic data raises new questions about how models generating the data can influence other large language models (LLMs) via distilled data. To start, our work exhaustively characterizes the impact of passive…

Computation and Language · Computer Science 2024-07-22 Luísa Shimabucoro , Sebastian Ruder , Julia Kreutzer , Marzieh Fadaee , Sara Hooker

Differentially private (DP) synthetic data sets are a solution for sharing data while preserving the privacy of individual data providers. Understanding the effects of utilizing DP synthetic data in end-to-end machine learning pipelines…

Machine Learning · Computer Science 2023-10-31 Mayana Pereira , Meghana Kshirsagar , Sumit Mukherjee , Rahul Dodhia , Juan Lavista Ferres , Rafael de Sousa

Synthetic data augmentation via large language models (LLMs) allows researchers to leverage additional training data, thus enhancing the performance of downstream tasks, especially when real-world data is scarce. However, the generated data…

Machine Learning · Computer Science 2025-03-25 Hsun-Yu Kuo , Yin-Hsiang Liao , Yu-Chieh Chao , Wei-Yun Ma , Pu-Jen Cheng

Synthetic data has become a pivotal resource in post-training tasks for large language models (LLMs) due to the scarcity of high-quality, specific data. While various methods have been developed to generate synthetic data, there remains a…

Artificial Intelligence · Computer Science 2025-02-07 Zeyu Gan , Yong Liu

Recent advancements in Large Language Models (LLMs) have led to high-quality Machine-Generated Text (MGT), giving rise to countless new use cases and applications. However, easy access to LLMs is posing new challenges due to misuse. To…

Computation and Language · Computer Science 2024-04-15 Areg Mikael Sarvazyan , José Ángel González , Marc Franco-Salvador

Personalized computed tomography (CT) dosimetry has great potential in assessing patient-specific radiation exposure, supporting risk assessment, and optimizing clinical protocols. The aim of this study is to evaluate the potential of…

Medical Physics · Physics 2026-01-15 Marie-Luise Kuhlmann , Jörg Martin , Stefan Pojtinger

This survey reviews how large language models (LLMs) are transforming synthetic training data generation in both natural language and code domains. By producing artificial but task-relevant examples, these models can significantly augment…

Computation and Language · Computer Science 2025-11-21 Mihai Nadas , Laura Diosan , Andreea Tomescu

The increasing need for data privacy and the demand for robust machine learning models have fueled the development of synthetic data generation techniques. However, current methods often succeed in replicating simple summary statistics but…

Machine Learning · Computer Science 2025-10-27 Jens E. d'Hondt , Wieger R. Punter , Odysseas Papapetrou

Large language models (LLMs) achieve strong performance across diverse tasks, largely driven by high-quality web data used in pre-training. However, recent studies indicate this data source is rapidly depleting. Synthetic data emerges as a…

Training generative machine learning models to produce synthetic tabular data has become a popular approach for enhancing privacy in data sharing. As this typically involves processing sensitive personal information, releasing either the…

Cryptography and Security · Computer Science 2026-02-02 Georgi Ganev , Emiliano De Cristofaro

There is a growing interest in utilizing synthetic populations for a diverse range of applications. At the same time, we are witnessing a tremendous growth in artificial intelligence in all walks of life. This paper evaluates whether…

Computers and Society · Computer Science 2026-05-28 Taylor Anderson , Sara Von Hoene , Orhan Yagizer Cinar , Emma Von Hoene , Amira Roess , Andrew Crooks , Hamdi Kavak