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This document outlines a tutorial to get started with medical image registration using the open-source package DeepReg. The basic concepts of medical image registration are discussed, linking classical methods to newer methods using deep…

Image and Video Processing · Electrical Eng. & Systems 2020-09-08 N. Montana Brown , Y. Fu , S. U. Saeed , A. Casamitjana , Z. M. C. Baum , R. Delaunay , Q. Yang , A. Grimwood , Z. Min , E. Bonmati , T. Vercauteren , M. J. Clarkson , Y. Hu

Multimodal image registration is a challenging but essential step for numerous image-guided procedures. Most registration algorithms rely on the computation of complex, frequently non-differentiable similarity metrics to deal with the…

Computer Vision and Pattern Recognition · Computer Science 2023-07-20 Matteo Ronchetti , Wolfgang Wein , Nassir Navab , Oliver Zettinig , Raphael Prevost

Image registration is a crucial task in signal processing, but it often encounters issues with stability and efficiency. Non-learning registration approaches rely on optimizing similarity metrics between fixed and moving images, which can…

Computer Vision and Pattern Recognition · Computer Science 2023-03-28 Zihao Wang , Hervé Delingette

Despite huge successes on a wide range of tasks, neural networks are known to sometimes struggle to generalise to unseen data. Many approaches have been proposed over the years to promote the generalisation ability of neural networks,…

Machine Learning · Computer Science 2026-02-02 Christiaan P. Opperman , Anna S. Bosman , Katherine M. Malan

3-D image registration, which involves aligning two or more images, is a critical step in a variety of medical applications from diagnosis to therapy. Image registration is commonly performed by optimizing an image matching metric as a cost…

Computer Vision and Pattern Recognition · Computer Science 2016-12-01 Rui Liao , Shun Miao , Pierre de Tournemire , Sasa Grbic , Ali Kamen , Tommaso Mansi , Dorin Comaniciu

In recent years, learning-based image registration methods have gradually moved away from direct supervision with target warps to instead use self-supervision, with excellent results in several registration benchmarks. These approaches…

Computer Vision and Pattern Recognition · Computer Science 2022-05-17 Sean I. Young , Yaël Balbastre , Adrian V. Dalca , William M. Wells , Juan Eugenio Iglesias , Bruce Fischl

How to extract more and useful information for single image super resolution is an imperative and difficult problem. Learning-based method is a representative method for such task. However, the results are not so stable as there may exist…

Image and Video Processing · Electrical Eng. & Systems 2020-03-25 Hu Liang , Shengrong Zhao

Diffeomorphic deformable image registration is crucial in many medical image studies, as it offers unique, special properties including topology preservation and invertibility of the transformation. Recent deep learning-based deformable…

Computer Vision and Pattern Recognition · Computer Science 2021-03-02 Tony C. W. Mok , Albert C. S. Chung

Deformable registration of magnetic resonance images between patients with brain tumors and healthy subjects has been an important tool to specify tumor geometry through location alignment and facilitate pathological analysis. Since tumor…

Image and Video Processing · Electrical Eng. & Systems 2021-01-19 Xiaofeng Liu , Fangxu Xing , Chao Yang , C. -C. Jay Kuo , Georges ElFakhri , Jonghye Woo

In recent years, a variety of learned regularization frameworks for solving inverse problems in imaging have emerged. These offer flexible modeling together with mathematical insights. The proposed methods differ in their architectural…

Deep learning algorithms, in particular convolutional networks, have rapidly become a methodology of choice for analyzing medical images. This paper reviews the major deep learning concepts pertinent to medical image analysis and summarizes…

Regularization methods are a key tool in the solution of inverse problems. They are used to introduce prior knowledge and make the approximation of ill-posed (pseudo-)inverses feasible. In the last two decades interest has shifted from…

Numerical Analysis · Mathematics 2018-01-31 Martin Benning , Martin Burger

Deformable image registration is fundamental to many medical imaging applications. Registration is an inherently ambiguous task often admitting many viable solutions. While neural network-based registration techniques enable fast and…

Computer Vision and Pattern Recognition · Computer Science 2024-07-16 Leonard Siegert , Paul Fischer , Mattias P. Heinrich , Christian F. Baumgartner

Medical image segmentation is a relevant task as it serves as the first step for several diagnosis processes, thus it is indispensable in clinical usage. Whilst major success has been reported using supervised techniques, they assume a…

Computer Vision and Pattern Recognition · Computer Science 2022-07-22 Lihao Liu , Angelica I Aviles-Rivero , Carola-Bibiane Schönlieb

Regularization is used in many different areas of optimization when solutions are sought which not only minimize a given function, but also possess a certain degree of regularity. Popular applications are image denoising, sparse regression…

Optimization and Control · Mathematics 2021-11-15 Bennet Gebken , Katharina Bieker , Sebastian Peitz

Medical image registration is a fundamental task in medical image analysis, enabling the alignment of images from different modalities or time points. However, intensity inconsistencies and nonlinear tissue deformations pose significant…

Computer Vision and Pattern Recognition · Computer Science 2026-04-23 Eytan Kats , Christoph Grossbroehmer , Ziad Al-Haj Hemidi , Fenja Falta , Wiebke Heyer , Mattias P. Heinrich

Classical deformable registration techniques achieve impressive results and offer a rigorous theoretical treatment, but are computationally intensive since they solve an optimization problem for each image pair. Recently, learning-based…

Computer Vision and Pattern Recognition · Computer Science 2019-07-26 Adrian V. Dalca , Guha Balakrishnan , John Guttag , Mert R. Sabuncu

Deformable image registration plays a critical role in various tasks of medical image analysis. A successful registration algorithm, either derived from conventional energy optimization or deep networks requires tremendous efforts from…

Computer Vision and Pattern Recognition · Computer Science 2023-08-15 Xin Fan , Zi Li , Ziyang Li , Xiaolin Wang , Risheng Liu , Zhongxuan Luo , Hao Huang

Denoising, the process of reducing random fluctuations in a signal to emphasize essential patterns, has been a fundamental problem of interest since the dawn of modern scientific inquiry. Recent denoising techniques, particularly in…

Machine Learning · Computer Science 2024-12-04 Peyman Milanfar , Mauricio Delbracio

Deep learning has revolutionized medical image registration by achieving unprecedented speeds, yet its clinical application is hindered by a limited ability to generalize beyond the training domain, a critical weakness given the typically…

Computer Vision and Pattern Recognition · Computer Science 2026-02-02 Fengting Zhang , Yue He , Qinghao Liu , Yaonan Wang , Xiang Chen , Hang Zhang