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Cancer diagnosis, prognosis, and therapeutic response predictions are based on morphological information from histology slides and molecular profiles from genomic data. However, most deep learning-based objective outcome prediction and…

Computer Vision and Pattern Recognition · Computer Science 2020-09-04 Richard J. Chen , Ming Y. Lu , Jingwen Wang , Drew F. K. Williamson , Scott J. Rodig , Neal I. Lindeman , Faisal Mahmood

Drug discovery and development is a complex and costly process. Machine learning approaches are being investigated to help improve the effectiveness and speed of multiple stages of the drug discovery pipeline. Of these, those that use…

Artificial Intelligence · Computer Science 2022-09-27 Stephen Bonner , Ian P Barrett , Cheng Ye , Rowan Swiers , Ola Engkvist , Andreas Bender , Charles Tapley Hoyt , William L Hamilton

In modern dynamic constantly developing society, more and more people suffer from chronic and serious diseases and doctors and patients need special and sophisticated medical and health support. Accordingly, prominent health stakeholders…

Computers and Society · Computer Science 2022-08-10 Mirjana Ivanovic , Serge Autexier , Miltiadis Kokkonidis

Fine-grained user profile generation approaches have made it increasingly feasible to display on a profile page in which topics a user has expertise or interest. Earlier work on topical user profiling has been directed at enhancing search…

Information Retrieval · Computer Science 2016-11-22 Alex Olieman , Jaap Kamps , Gleb Satyukov , Emil de Valk

This work emphasizes the assets of implementing the distributed computing for the intensive use in computational science devoted to the search of new medicines that could be applied in public healthy problems.

Quantitative Methods · Quantitative Biology 2010-12-15 Raul Isea , Rafael Mayo

The advent of the digital pathology has introduced new avenues of diagnostic medicine. Among them, crowdsourcing has attracted researchers' attention in the recent years, allowing them to engage thousands of untrained individuals in…

Human-Computer Interaction · Computer Science 2017-11-22 Roshanak Alialy , Sasan Tavakkol , Elham Tavakkol , Amir Ghorbani-Aghbologhi , Alireza Ghaffarieh , Seon Ho Kim , Cyrus Shahabi

Over the past decades, the incidence of thyroid cancer has been increasing globally. Accurate and early diagnosis allows timely treatment and helps to avoid over-diagnosis. Clinically, a nodule is commonly evaluated from both transverse and…

Computer Vision and Pattern Recognition · Computer Science 2022-07-04 Han Huang , Yijie Dong , Xiaohong Jia , Jianqiao Zhou , Dong Ni , Jun Cheng , Ruobing Huang

Despite the significant advances in life science, it still takes decades to translate a basic drug discovery into a cure for human disease. To accelerate the process from bench to bedside, interdisciplinary research (especially research…

Other Quantitative Biology · Quantitative Biology 2021-09-08 Xin Li , Xuli Tang

The emerging trend of advancing generalist artificial intelligence, such as GPTv4 and Gemini, has reshaped the landscape of research (academia and industry) in machine learning and many other research areas. However, domain-specific…

Computer Vision and Pattern Recognition · Computer Science 2024-03-05 Xiaosong Wang , Xiaofan Zhang , Guotai Wang , Junjun He , Zhongyu Li , Wentao Zhu , Yi Guo , Qi Dou , Xiaoxiao Li , Dequan Wang , Liang Hong , Qicheng Lao , Tong Ruan , Yukun Zhou , Yixue Li , Jie Zhao , Kang Li , Xin Sun , Lifeng Zhu , Shaoting Zhang

In the genomic era, the identification of gene signatures associated with disease is of significant interest. Such signatures are often used to predict clinical outcomes in new patients and aid clinical decision-making. However, recent…

Methodology · Statistics 2019-03-27 Naim U. Rashid , Quefeng Li , Jen Jen Yeh , Joseph G. Ibrahim

In the absence of sufficient medication for COVID patients due to the increased demand, disused drugs have been employed or the doses of those available were modified by hospital pharmacists. Some evidences for the use of alternative drugs…

Ontologies in the biomedical domain are numerous, highly specialized and very expensive to develop. Thus, a crucial prerequisite for ontology adoption and reuse is effective support for exploring and finding existing ontologies. Towards…

Social and Information Networks · Computer Science 2022-05-17 Simon Walk , Lisette Espín-Noboa , Denis Helic , Markus Strohmaier , Mark Musen

Knowledge graphs are an increasingly common data structure for representing biomedical information. These knowledge graphs can easily represent heterogeneous types of information, and many algorithms and tools exist for querying and…

We introduce iFacetSum, a web application for exploring topical document sets. iFacetSum integrates interactive summarization together with faceted search, by providing a novel faceted navigation scheme that yields abstractive summaries for…

Computation and Language · Computer Science 2021-09-27 Eran Hirsch , Alon Eirew , Ori Shapira , Avi Caciularu , Arie Cattan , Ori Ernst , Ramakanth Pasunuru , Hadar Ronen , Mohit Bansal , Ido Dagan

Quantum computing holds significant potential for applications in biology and medicine, spanning from the simulation of biomolecules to machine learning approaches for subtyping cancers on the basis of clinical features. This potential is…

Biomarkers play a central role in medicine's gradual progress towards proactive, personalized precision diagnostics and interventions. However, finding biomarkers that provide very early indicators of a change in health status, for example…

Clinicians face several significant barriers to search and synthesize accurate, succinct, updated, and trustworthy medical information from several literature sources during the practice of medicine and patient care. In this talk, we will…

This article reviews recent advances in applying natural language processing (NLP) to Electronic Health Records (EHRs) for computational phenotyping. NLP-based computational phenotyping has numerous applications including diagnosis…

Computation and Language · Computer Science 2018-06-18 Zexian Zeng , Yu Deng , Xiaoyu Li , Tristan Naumann , Yuan Luo

Computer-Aided Drug Discovery research has proven to be a promising direction in drug discovery. In recent years, Deep Learning approaches have been applied to problems in the domain such as Drug-Target Interaction Prediction and have shown…

Machine Learning · Computer Science 2020-04-28 Brighter Agyemang , Wei-Ping Wu , Michael Y. Kpiebaareh , Ebenezer Nanor

Query reformulation is the process by which a input search query is refined by the user to match documents outside the original top-n results. On average, roughly 50% of text search queries involve some form of reformulation, and term…

Computer Vision and Pattern Recognition · Computer Science 2019-10-29 Kyle Xiao , Houdong Hu , Yan Wang