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Academic Clinical Trial Units frequently face fragmented statistical workflows, leading to duplicated effort, limited collaboration, and inconsistent analytical practices. To address these challenges within an oncology Clinical Trial Unit,…

Background The use of a clinical decision support system for assessing the quality of care, based on computerized clinical guidelines (GLs), is likely to improve care, reduce costs, save time, and enhance the staff's capabilities.…

Artificial Intelligence · Computer Science 2024-10-16 Erez Shalom , Ayelet Goldstein , Roni Wais , Maya Slivanova , Nogah Melamed Cohen , Yuval Shahar

Clinical decision-making is inherently complex and fast-paced, particularly in emergency departments (EDs) where critical, rapid and high-stakes decisions are made. Clinical Decision Rules (CDRs) are standardized evidence-based tools that…

Evaluating radiology reports is a challenging problem as factual correctness is extremely important due to the need for accurate medical communication about medical images. Existing automatic evaluation metrics either suffer from failing to…

Research in the area of automated test generation has seen remarkable progress in recent years, resulting in several approaches and tools for effective and efficient generation of test cases. In particular, the EvoSuite tool has been at the…

Software Engineering · Computer Science 2025-01-17 Fitsum Kifetew , Davide Prandi , Angelo Susi

Deep Neural Networks (DNNs), with its promising performance, are being increasingly used in safety critical applications such as autonomous driving, cancer detection, and secure authentication. With growing importance in deep learning,…

Machine Learning · Computer Science 2019-11-19 Senthil Mani , Anush Sankaran , Srikanth Tamilselvam , Akshay Sethi

Motivation: Precision medicine is a major trend in the future of medicine. It aims to provide tailored medical treatment and prevention strategies based on an individual's unique characteristics and needs. Biomarker is the primary source of…

Methodology · Statistics 2023-05-17 Liuyi Lan , Xuanjin Cheng , Li Xing , Xuekui Zhang

Brain tumors are a complex and potentially life-threatening medical condition that requires accurate diagnosis and timely treatment. In this paper, we present a machine learning-based system designed to assist healthcare professionals in…

Image and Video Processing · Electrical Eng. & Systems 2023-04-18 Belal Badawy , Romario Sameh Samir , Youssef Tarek , Mohammed Ahmed , Rana Ibrahim , Manar Ahmed , Mohamed Hassan

Translation of fully automated deep learning based medical image segmentation technologies to clinical workflows face two main algorithmic challenges. The first, is the collection and archival of large quantities of manually annotated…

Image and Video Processing · Electrical Eng. & Systems 2021-01-20 Bilwaj Gaonkar , Joel Beckett , Mark Attiah , Christine Ahn , Matthew Edwards , Bayard Wilson , Azim Laiwalla , Banafsheh Salehi , Bryan Yoo , Alex Bui , Luke Macyszyn

Brain tumors are increasingly prevalent, characterized by the uncontrolled spread of aberrant tissues in the brain, with almost 700,000 new cases diagnosed globally each year. Magnetic Resonance Imaging (MRI) is commonly used for the…

Image and Video Processing · Electrical Eng. & Systems 2023-10-23 Javed Hossain , Md. Touhidul Islam , Md. Taufiqul Haque Khan Tusar

In routine colorectal cancer management, histologic samples stained with hematoxylin and eosin are commonly used. Nonetheless, their potential for defining objective biomarkers for patient stratification and treatment selection is still…

Quantitative Methods · Quantitative Biology 2024-09-26 Fabi Prezja , Leevi Annala , Sampsa Kiiskinen , Suvi Lahtinen , Timo Ojala , Pekka Ruusuvuori , Teijo Kuopio

The growing use of deep neural networks in safety-critical applications makes it necessary to carry out adequate testing to detect and correct any incorrect behavior for corner case inputs before they can be actually used. Deep neural…

Software Engineering · Computer Science 2019-02-19 Jasmine Sekhon , Cody Fleming

Model checking of real-time systems has evolved throughout the years. Recently, the model checker Ecdar, using timed I/O automata, was used to perform compositional verification. However, in order to fully integrate model checking of…

Software Engineering · Computer Science 2018-09-12 Tobias R. Gundersen , Florian Lorber , Ulrik Nyman , Christian Ovesen

We present GNN-Suite, a robust modular framework for constructing and benchmarking Graph Neural Network (GNN) architectures in computational biology. GNN-Suite standardises experimentation and reproducibility using the Nextflow workflow to…

Machine Learning · Computer Science 2025-05-19 Sebestyén Kamp , Giovanni Stracquadanio , T. Ian Simpson

In the last two decades Computer Aided Diagnostics (CAD) systems were developed to help radiologists analyze screening mammograms. The benefits of current CAD technologies appear to be contradictory and they should be improved to be…

Computer Vision and Pattern Recognition · Computer Science 2017-11-10 Dezső Ribli , Anna Horváth , Zsuzsa Unger , Péter Pollner , István Csabai

Artificial intelligence (AI) has brought tremendous impacts on biomedical sciences from academic researches to clinical applications, such as in biomarkers' detection and diagnosis, optimization of treatment, and identification of new…

Quantitative Methods · Quantitative Biology 2023-03-14 Yu-Jia An , Sheng-Chen Bai , Lin Cheng , Xiao-Guang Li , Cheng-en Wang , Xiao-Dong Han , Gang Su , Shi-Ju Ran , Cong Wang

One of the methods for stratifying different molecular classes of breast cancer is the Nottingham Prognostic Index Plus (NPI+) which uses breast cancer relevant biomarkers to stain tumour tissues prepared on tissue microarray (TMA). To…

Computer Vision and Pattern Recognition · Computer Science 2019-01-15 Jingxin Liu , Bolei Xu , Chi Zheng , Yuanhao Gong , Jon Garibaldi , Daniele Soria , Andew Green , Ian O. Ellis , Wenbin Zou , Guoping Qiu

PURPOSE: The medical literature relevant to germline genetics is growing exponentially. Clinicians need tools monitoring and prioritizing the literature to understand the clinical implications of the pathogenic genetic variants. We…

Biomarker testing is a laboratory test in oncology that is used in the selection of targeted cancer treatments and helping to avoid ineffective treatments. There exist several types of biomarker tests that can be used to detect the presence…

Quantitative Methods · Quantitative Biology 2022-10-05 Marzieh Soltanolkottabi , Hadi A. Khorshidi , Maarten J. IJzerman

In modern cancer research, the vast volume of medical data generated is often underutilised due to challenges related to patient privacy. The OncoReg Challenge addresses this issue by enabling researchers to develop and validate image…