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The Cancer Registry of Norway (CRN) collects, curates, and manages data related to cancer patients in Norway, supported by an interactive, human-in-the-loop, socio-technical decision support software system. Automated software testing of…

Software Engineering · Computer Science 2023-11-07 Christoph Laaber , Tao Yue , Shaukat Ali , Thomas Schwitalla , Jan F. Nygård

The Cancer Registry of Norway (CRN) is a public body responsible for capturing and curating cancer patient data histories to provide a unified access to research data and statistics for doctors, patients, and policymakers. For this purpose,…

Software Engineering · Computer Science 2023-08-28 Christoph Laaber , Tao Yue , Shaukat Ali , Thomas Schwitalla , Jan F. Nygård

The Cancer Registration Support System (CaReSS), built by the Cancer Registry of Norway (CRN), is a complex real-world socio-technical software system that undergoes continuous evolution in its implementation. Consequently, continuous…

Software Engineering · Computer Science 2023-10-02 Erblin Isaku , Hassan Sartaj , Christoph Laaber , Tao Yue , Shaukat Ali , Thomas Schwitalla , Jan F. Nygård

The Cancer Registry of Norway (CRN) uses an automated cancer registration support system (CaReSS) to support core cancer registry activities, i.e, data capture, data curation, and producing data products and statistics for various…

Software Engineering · Computer Science 2025-03-03 Erblin Isaku , Christoph Laaber , Hassan Sartaj , Shaukat Ali , Thomas Schwitalla , Jan F. Nygård

The Cancer Registry of Norway (CRN) is a part of the Norwegian Institute of Public Health (NIPH) and is tasked with producing statistics on cancer among the Norwegian population. For this task, CRN develops, tests, and evolves a software…

Software Engineering · Computer Science 2024-11-08 Xinyi Wang , Shaukat Ali , Paolo Arcaini , Narasimha Raghavan Veeraragavan , Jan F. Nygård

Objective: The majority of detailed patient information in real-world data (RWD) is only consistently available in free-text clinical documents. Manual curation is expensive and time-consuming. Developing natural language processing (NLP)…

Transcriptional profiling on microarrays to obtain gene expressions has been used to facilitate cancer diagnosis. We propose a deep generative machine learning architecture (called DeepCancer) that learn features from unlabeled microarray…

Artificial Intelligence · Computer Science 2016-12-14 Rajendra Rana Bhat , Vivek Viswanath , Xiaolin Li

A large number of people suffer from life-threatening cardiac abnormalities, and electrocardiogram (ECG) analysis is beneficial to determining whether an individual is at risk of such abnormalities. Automatic ECG classification methods,…

Artificial Intelligence · Computer Science 2022-06-23 Yuexin Bian , Jintai Chen , Xiaojun Chen , Xiaoxian Yang , Danny Z. Chen , JIan Wu

Deep learning has emerged as a prominent field in recent literature, showcasing the introduction of models that utilize transfer learning to achieve remarkable accuracies in the classification of brain tumor MRI images. However, the…

Computer Vision and Pattern Recognition · Computer Science 2023-08-15 Raza Imam , Mohammed Talha Alam

The receiver operating characteristic (ROC) curve is the most popular tool used to evaluate the discriminatory capability of diagnostic tests/biomarkers measured on a continuous scale when distinguishing between two alternative disease…

Methodology · Statistics 2021-03-22 Maria Xose Rodriguez-Alvarez , Vanda Inacio

Assessing the effectiveness of REST API tests in black-box settings can be challenging due to the lack of access to source code coverage metrics and polyglot tech stack. We propose three metrics for capturing average, minimum, and maximum…

Software Engineering · Computer Science 2026-05-27 Nana Reinikainen , Mika Mäntylä , Yuqing Wang

Electronic health records contain inconsistently structured or free-text data, requiring efficient preprocessing to enable predictive health care models. Although artificial intelligence-driven natural language processing tools show promise…

Nanopore sequencing can read substantially longer sequences of nucleic acid molecules, called reads, than other sequencing methods, which has led to advances in genomic analysis such as the gapless human genome assembly. By analyzing the…

Genomics · Quantitative Biology 2026-05-21 Simon Ambrozak , Ulysse McConnell , Bhargav Srinivasan , Burak Ozkan , Ernest Zhang , Can Firtina

Remote Procedure Call (RPC) is a communication protocol to support client-server interactions among services over a network. RPC is widely applied in industry for building large-scale distributed systems, such as Microservices. Modern RPC…

Software Engineering · Computer Science 2023-02-06 Man Zhang , Andrea Arcuri , Yonggang Li , Yang Liu , Kaiming Xue

Clinical Practice Guidelines (CPGs) for cancer diseases evolve rapidly due to new evidence generated by active research. Currently, CPGs are primarily published in a document format that is ill-suited for managing this developing knowledge.…

Artificial Intelligence · Computer Science 2023-07-21 Pralaypati Ta , Bhumika Gupta , Arihant Jain , Sneha Sree C , Arunima Sarkar , Keerthi Ram , Mohanasankar Sivaprakasam

Aiming at the limitations of traditional medical decision system in processing large-scale heterogeneous medical data and realizing highly personalized recommendation, this paper introduces a personalized medical decision algorithm…

Machine Learning · Computer Science 2024-05-29 Yafeng Yan , Shuyao He , Zhou Yu , Jiajie Yuan , Ziang Liu , Yan Chen

Automated unit test generators, particularly search-based software testing tools like EvoSuite, are capable of generating tests with high coverage. Although these generators alleviate the burden of writing unit tests, they often pose…

Software Engineering · Computer Science 2024-08-22 Amirhossein Deljouyi , Roham Koohestani , Maliheh Izadi , Andy Zaidman

Cancer treatments require personalized approaches based on a patient's clinical condition, medical history, and evidence-based guidelines. The National Comprehensive Cancer Network (NCCN) provides frequently updated, complex guidelines…

Information Retrieval · Computer Science 2025-02-25 Abdul M. Mohammed , Iqtidar Mansoor , Sarah Blythe , Dennis Trujillo

The complicated, evolving landscape of cancer mutations poses a formidable challenge to identify cancer genes among the large lists of mutations typically generated in NGS experiments. The ability to prioritize these variants is therefore…

A reliable fault diagnosis system should not only accurately classify known health states but also effectively identify unknown faults. In multimode processes, samples belonging to the same health state often show multiple cluster…

Machine Learning · Computer Science 2025-11-13 Guangqiang Li , M. Amine Atoui , Xiangshun Li
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