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Computational methods for assessing the likely impacts of mutations, known as variant effect predictors (VEPs), are widely used in the assessment and interpretation of human genetic variation, as well as in other applications like protein…

We develop a variational encrypted model predictive control (VEMPC) protocol whose online execution relies only on encrypted polynomial operations. The proposed approach reformulates the MPC problem into a sampling-based estimator, in which…

Systems and Control · Electrical Eng. & Systems 2026-03-23 Jihoon Suh , Yeongjun Jang , Junsoo Kim , Takashi Tanaka

Venn Prediction (VP) is a new machine learning framework for producing well-calibrated probabilistic predictions. In particular it provides well-calibrated lower and upper bounds for the conditional probability of an example belonging to…

Machine Learning · Computer Science 2023-12-18 Harris Papadopoulos

Post-click conversion rate (CVR) is a reliable indicator of online customers' preferences, making it crucial for developing recommender systems. A major challenge in predicting CVR is severe selection bias, arising from users' inherent…

Artificial Intelligence · Computer Science 2025-12-02 Wenbo Hu , Xin Sun , Qiang liu , Le Wu , Liang Wang

Variational inference is an alternative estimation technique for Bayesian models. Recent work shows that variational methods provide consistent estimation via efficient, deterministic algorithms. Other tools, such as model selection using…

Methodology · Statistics 2023-08-01 Mark J. Meyer , Selina Carter , Elizabeth J. Malloy

Brittle optimization has been observed to adversely impact model likelihoods for regression and VAEs when simultaneously fitting neural network mappings from a (random) variable onto the mean and variance of a dependent Gaussian variable.…

Machine Learning · Computer Science 2020-11-02 Andrew Stirn , David A. Knowles

The R package CVEK introduces a suite of flexible machine learning models and robust hypothesis tests for learning the joint nonlinear effects of multiple covariates in limited samples. It implements the Cross-validated Ensemble of Kernels…

Computation · Statistics 2020-12-22 Wenying Deng , Jeremiah Zhe Liu , Erin Lake , Brent A. Coull

Benchmarks for the evaluation of model performance play an important role in machine learning. However, there is no established way to describe and create new benchmarks. What is more, the most common benchmarks use performance measures…

Machine Learning · Computer Science 2022-09-23 Alicja Gosiewska , Katarzyna Woźnica , Przemysław Biecek

We present two a posteriori error estimators for the virtual element method (VEM) based on global and local flux reconstruction in the spirit of [5]. The proposed error estimators are reliable and efficient for the $h$-, $p$-, and…

Numerical Analysis · Mathematics 2025-03-14 F. Dassi , J. Gedicke , L. Mascotto

Vector Error Correction Model (VECM) is a classic method to analyse cointegration relationships amongst multivariate non-stationary time series. In this paper, we focus on high dimensional setting and seek for sample-size-efficient…

Methodology · Statistics 2024-03-13 Parley R Yang , Alexander Y Shestopaloff

Recent studies have explored the use of deep generative models of speech spectra based of variational autoencoders (VAEs), combined with unsupervised noise models, to perform speech enhancement. These studies developed iterative algorithms…

Sound · Computer Science 2019-05-15 Manuel Pariente , Antoine Deleforge , Emmanuel Vincent

Approximating complex probability densities is a core problem in modern statistics. In this paper, we introduce the concept of Variational Inference (VI), a popular method in machine learning that uses optimization techniques to estimate…

Machine Learning · Computer Science 2021-11-23 Ankush Ganguly , Samuel W. F. Earp

Understanding visual inputs for a given task amidst varied changes is a key challenge posed by visual reinforcement learning agents. We propose \textit{Value Explicit Pretraining} (VEP), a method that learns generalizable representations…

Machine Learning · Computer Science 2026-05-04 Kiran Lekkala , Henghui Bao , Sumedh A. Sontakke , Erdem Biyik , Laurent Itti

Meta-regression models are commonly used to synthesize and compare effect sizes. Unfortunately, traditional meta-regression methods are ill-equipped to handle the complex and often unknown correlations among non-independent effect sizes.…

Methodology · Statistics 2015-03-10 Zachary Fisher , Elizabeth Tipton

A storm of favorable or critical publications regarding p-values-based procedures has been observed in both the theoretical and applied literature. We focus on valid definitions of p-values in the scenarios when composite null models are in…

Methodology · Statistics 2020-01-16 Albert Vexler

Bayesian inference provides principled uncertainty quantification, but accurate posterior sampling with MCMC can be computationally prohibitive for modern applications. Variational inference (VI) offers a scalable alternative and often…

Methodology · Statistics 2026-05-14 Laura Battaglia , Stefano Cortinovis , Chris Holmes , David T. Frazier , Jack Jewson

Variants of Uncertain Significance (VUS) limit the clinical utility of prostate cancer genomics by delaying diagnosis and therapy when evidence for pathogenicity or benignity is incomplete. Progress is further limited by inconsistent…

Quantitative Methods · Quantitative Biology 2025-11-14 Abraham Francisco Arellano Tavara , Umesh Kumar , Jathurshan Pradeepkumar , Jimeng Sun

Improving the robustness of neural nets in regression tasks is key to their application in multiple domains. Deep learning-based approaches aim to achieve this goal either by improving their prediction of specific values (i.e., point…

Machine Learning · Computer Science 2021-06-22 Eli Simhayev , Gilad Katz , Lior Rokach

Machine learning models provide statistically impressive results which might be individually unreliable. To provide reliability, we propose an Epistemic Classifier (EC) that can provide justification of its belief using support from the…

Machine Learning · Computer Science 2020-10-20 Chitresh Bhushan , Zhaoyuan Yang , Nurali Virani , Naresh Iyer

Virtual Diagnostic (VD) is a computational tool based on deep learning that can be used to predict a diagnostic output. VDs are especially useful in systems where measuring the output is invasive, limited, costly or runs the risk of…

Accelerator Physics · Physics 2021-08-04 Owen Convery , Lewis Smith , Yarin Gal , Adi Hanuka
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