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Replicating causal estimates across different cohorts is crucial for increasing the integrity of epidemiological studies. However, strong assumptions regarding unmeasured confounding and effect modification often hinder this goal. By…

Methodology · Statistics 2024-09-23 Roy S. Zawadzki , Daniel L. Gillen

Randomized controlled trials (RCTs) are the gold standard for estimating heterogeneous treatment effects, yet they are often underpowered for detecting effect heterogeneity. Large observational studies (OS) can supplement RCTs for…

Machine Learning · Computer Science 2026-04-07 Amir Asiaee , Samhita Pal

The conditional average treatment effect (CATE) is frequently estimated to refute the homogeneous treatment effect assumption. Under this assumption, all units making up the population under study experience identical benefit from a given…

In real-world applications, as data availability increases, obtaining labeled data for machine learning (ML) projects remains challenging due to the high costs and intensive efforts required for data annotation. Many ML projects,…

Machine Learning · Computer Science 2024-12-24 Ismail Hakki Karaman , Gulser Koksal , Levent Eriskin , Salih Salihoglu

This paper presents a conformal prediction method for classification in highly imbalanced and open-set settings, where there are many possible classes and not all may be represented in the data. Existing approaches require a finite, known…

Machine Learning · Statistics 2025-10-16 Tianmin Xie , Yanfei Zhou , Ziyi Liang , Stefano Favaro , Matteo Sesia

A common issue for classification in scientific research and industry is the existence of imbalanced classes. When sample sizes of different classes are imbalanced in training data, naively implementing a classification method often leads…

Methodology · Statistics 2021-07-02 Yang Feng , Min Zhou , Xin Tong

This paper introduces a novel oversampling technique designed to improve classification performance on imbalanced datasets. The proposed method enhances the traditional SMOTE algorithm by incorporating convex combination and kernel-based…

Machine Learning · Computer Science 2025-04-15 Wenjie Li , Sibo Zhu , Zhijian Li , Hanlin Wang

Class imbalance (CI) in classification problems arises when the number of observations belonging to one class is lower than the other. Ensemble learning combines multiple models to obtain a robust model and has been prominently used with…

Machine Learning · Computer Science 2023-11-28 Azal Ahmad Khan , Omkar Chaudhari , Rohitash Chandra

Developing new drugs for target diseases is a time-consuming and expensive task, drug repurposing has become a popular topic in the drug development field. As much health claim data become available, many studies have been conducted on the…

Machine Learning · Computer Science 2023-02-22 Yaobin Ling , Pulakesh Upadhyaya , Luyao Chen , Xiaoqian Jiang , Yejin Kim

The accurate automated classification of variable stars into their respective sub-types is difficult. Machine learning based solutions often fall foul of the imbalanced learning problem, which causes poor generalisation performance in…

Instrumentation and Methods for Astrophysics · Physics 2020-03-18 Zafiirah Hosenie , Robert Lyon , Benjamin Stappers , Arrykrishna Mootoovaloo , Vanessa McBride

In many practical situations, randomly assigning treatments to subjects is uncommon due to feasibility constraints. For example, economic aid programs and merit-based scholarships are often restricted to those meeting specific income or…

Data from observational studies (OSs) is widely available and readily obtainable yet frequently contains confounding biases. On the other hand, data derived from randomized controlled trials (RCTs) helps to reduce these biases; however, it…

Methodology · Statistics 2024-10-30 Dong Yao , Caizhi Tang , Qing Cui , Longfei Li

The estimation of heterogeneous treatment effects (HTEs) has attracted considerable interest in many disciplines, most prominently in medicine and economics. Contemporary research has so far primarily focused on continuous and binary…

Methodology · Statistics 2022-10-07 Susanne Dandl , Andreas Bender , Torsten Hothorn

This paper considers the problem of error correction in multi-class classification of face images on unbalanced samples. The study is based on the analysis of a data frame containing images labeled by seven different emotional states of…

Computer Vision and Pattern Recognition · Computer Science 2025-10-07 Andrey A. Lebedev , Victor B. Kazantsev , Sergey V. Stasenko

Imbalanced classification problems are extremely common in natural language processing and are solved using a variety of resampling and filtering techniques, which often involve making decisions on how to select training data or decide…

Computation and Language · Computer Science 2022-09-02 Ryan Muther , David Smith

Within the field of causal inference, we consider the problem of estimating heterogeneous treatment effects from data. We propose and validate a novel approach for learning feature representations to aid the estimation of the conditional…

Machine Learning · Statistics 2022-06-23 Michael C. Burkhart , Gabriel Ruiz

Accurate heterogeneous treatment effect (HTE) estimation is essential for personalized recommendations, making it important to evaluate and compare HTE estimators. Traditional assessment methods are inapplicable due to missing…

Methodology · Statistics 2024-12-30 Zijun Gao

In this position and problem pitch paper, we offer a solution to the reference class problem in causal inference. We apply the Reconcile algorithm for model multiplicity in machine learning to reconcile heterogeneous effects in causal…

Machine Learning · Computer Science 2024-06-12 Audrey Chang , Emily Diana , Alexander Williams Tolbert

Class imbalance poses a significant challenge to supervised classification, particularly in critical domains like medical diagnostics and anomaly detection where minority class instances are rare. While numerous studies have explored…

Machine Learning · Computer Science 2025-09-10 Ali Nawaz , Amir Ahmad , Shehroz S. Khan

When using machine learning for imbalanced binary classification problems, it is common to subsample the majority class to create a (more) balanced training dataset. This biases the model's predictions because the model learns from data…

Machine Learning · Computer Science 2025-11-03 Nathan Phelps , Daniel J. Lizotte , Douglas G. Woolford