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Foundation models for single-cell RNA sequencing (scRNA-seq) have shown promising capabilities in capturing gene expression patterns. However, current approaches face critical limitations: they ignore biological prior knowledge encoded in…

Machine Learning · Computer Science 2025-03-04 Mufan Qiu , Xinyu Hu , Fengwei Zhan , Sukwon Yun , Jie Peng , Ruichen Zhang , Bhavya Kailkhura , Jiekun Yang , Tianlong Chen

Learning representations on large-sized graphs is a long-standing challenge due to the inter-dependence nature involved in massive data points. Transformers, as an emerging class of foundation encoders for graph-structured data, have shown…

Machine Learning · Computer Science 2024-08-19 Qitian Wu , Wentao Zhao , Chenxiao Yang , Hengrui Zhang , Fan Nie , Haitian Jiang , Yatao Bian , Junchi Yan

Machine learning has revolutionized many fields, including materials science. However, predicting properties of crystalline materials using machine learning faces challenges in input encoding, output versatility, and interpretability. We…

Materials Science · Physics 2025-05-22 Haosheng Xu , Dongheng Qian , Jing Wang

Organic semiconductors are promising materials for cheap, scalable and sustainable electronics, light-emitting diodes and photovoltaics. For organic photovoltaic cells, it is a challenge to find compounds with suitable properties in the…

Materials Science · Physics 2023-03-06 Christopher Gaul , Santiago Cuesta-Lopez

Detecting manipulations in digital documents is becoming increasingly important for information verification purposes. Due to the proliferation of image editing software, altering key information in documents has become widely accessible.…

Computer Vision and Pattern Recognition · Computer Science 2023-06-27 Hailey Joren , Otkrist Gupta , Dan Raviv

The discovery of new molecules based on the original chemical molecule distributions is of great importance in medicine. The graph transformer, with its advantages of high performance and scalability compared to traditional graph networks,…

Machine Learning · Computer Science 2025-04-30 Ji Shi , Chengxun Xie , Zhonghao Li , Xinming Zhang , Miao Zhang

Sea Surface Temperature (SST) prediction plays a vital role in climate modeling and disaster forecasting. However, it remains challenging due to its nonlinear spatiotemporal dynamics and extended prediction horizons. To address this, we…

Computer Vision and Pattern Recognition · Computer Science 2026-01-13 Yin Wang , Chunlin Gong , Zhuozhen Xu , Lehan Zhang , Xiang Wu

Retrosynthesis prediction is one of the fundamental challenges in organic synthesis. The task is to predict the reactants given a core product. With the advancement of machine learning, computer-aided synthesis planning has gained…

Chemical Physics · Physics 2022-02-01 Yue Wan , Benben Liao , Chang-Yu Hsieh , Shengyu Zhang

Organic solar cells (OSCs) have recently shown a rapid improvement in their performance, bringing power conversion efficiencies (PCEs) closer to the point where commercial applications of the technology become viable. However, the low…

The search for new high-performance organic semiconducting molecules is challenging due to the vastness of the chemical space, machine learning methods, particularly deep learning models like graph neural networks (GNNs), have shown…

Chemical Physics · Physics 2021-12-06 Zaixi Zhang , Qi Liu , Shengyu Zhang , Chang-Yu Hsieh , Liang Shi , Chee-Kong Lee

Algorithms for the action segmentation task typically use temporal models to predict what action is occurring at each frame for a minute-long daily activity. Recent studies have shown the potential of Transformer in modeling the relations…

Computer Vision and Pattern Recognition · Computer Science 2021-10-19 Fangqiu Yi , Hongyu Wen , Tingting Jiang

Structured reconstruction is a non-trivial dense prediction problem, which extracts structural information (\eg, building corners and edges) from a raster image, then reconstructs it to a 2D planar graph accordingly. Compared with common…

Computer Vision and Pattern Recognition · Computer Science 2023-12-13 Hongbo Tian , Yulong Li , Linzhi Huang , Xu Ling , Yue Yang , Jiani Hu

Topological Deep Learning seeks to enhance the predictive performance of neural network models by harnessing topological structures in input data. Topological neural networks operate on spaces such as cell complexes and hypergraphs, that…

Most recent scribble-supervised segmentation methods commonly adopt a CNN framework with an encoder-decoder architecture. Despite its multiple benefits, this framework generally can only capture small-range feature dependency for the…

Computer Vision and Pattern Recognition · Computer Science 2024-02-06 Zihan Li , Yuan Zheng , Dandan Shan , Shuzhou Yang , Qingde Li , Beizhan Wang , Yuanting Zhang , Qingqi Hong , Dinggang Shen

Graph Transformers have recently attracted attention for molecular property prediction by combining the inductive biases of graph neural networks (GNNs) with the global receptive field of Transformers. However, many existing hybrid…

Machine Learning · Computer Science 2026-04-09 Yi Yang , Ovidiu Daescu

The integration of single-cell proteomic data is often hindered by the fragmented nature of targeted antibody panels. To address this limitation, we introduce scpFormer, a transformer-based foundation model designed for single-cell…

Quantitative Methods · Quantitative Biology 2026-04-23 Qifeng Zhou , Lei Yu , Yuzhi Guo , Yuwei Miao , Hehuan Ma , Wenliang Zhong , Lin Xu , Junzhou Huang

The traditional Transformer model encounters challenges with variable-length input sequences, particularly in Hyperspectral Image Classification (HSIC), leading to efficiency and scalability concerns. To overcome this, we propose a…

Computer Vision and Pattern Recognition · Computer Science 2024-09-20 Muhammad Ahmad , Muhammad Hassaan Farooq Butt , Manuel Mazzara , Salvatore Distifano

Spatio-temporal traffic forecasting is challenging due to complex temporal patterns, dynamic spatial structures, and diverse input formats. Although Transformer-based models offer strong global modeling, they often struggle with rigid…

Artificial Intelligence · Computer Science 2025-08-20 Jiayu Fang , Zhiqi Shao , S T Boris Choy , Junbin Gao

Understanding the chemical structure from a graphical representation of a molecule is a challenging image caption task that would greatly benefit molecule-centric scientific discovery. Variations in molecular images and caption subtasks…

Computer Vision and Pattern Recognition · Computer Science 2025-05-23 Siqi Fan , Yuguang Xie , Bowen Cai , Ailin Xie , Gaochao Liu , Mu Qiao , Jie Xing , Zaiqing Nie

Reticular materials, including metal-organic frameworks and covalent organic frameworks, combine relative ease of synthesis and an impressive range of applications in various fields, from gas storage to biomedicine. Diverse properties arise…

Materials Science · Physics 2024-03-11 Vadim Korolev , Artem Mitrofanov
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