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Timely and accurate assessment of cognitive impairment remains a major unmet need. Speech biomarkers offer a scalable, non-invasive, cost-effective solution for automated screening. However, the clinical utility of machine learning (ML)…

In the past decade, there has been a surge in research examining the use of voice and speech analysis as a means of detecting neurodegenerative diseases such as Alzheimer's. Many studies have shown that certain acoustic features can be used…

Audio and Speech Processing · Electrical Eng. & Systems 2023-07-20 Vrindha M. K. , Geethu V. , Anurenjan P. R. , Deepak S. , Sreeni K. G.

Alzheimer s disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, where early detection is essential for timely intervention and improved patient outcomes. Traditional diagnostic methods are…

Early detection is crucial to prevent the progression of Alzheimer's disease (AD). Thus, specialists can begin preventive treatment as soon as possible. They demand fast and precise assessment in the diagnosis of AD in the earliest and…

Machine Learning · Computer Science 2021-05-19 Alejandro Puente-Castro , Enrique Fernandez-Blanco , Alejandro Pazos , Cristian R. Munteanu

In the rapidly evolving landscape of medical documentation, transcribing clinical dialogues accurately is increasingly paramount. This study explores the potential of Large Language Models (LLMs) to enhance the accuracy of Automatic Speech…

Computation and Language · Computer Science 2024-02-13 Ayo Adedeji , Sarita Joshi , Brendan Doohan

This paper describes a multi-modal approach for the automatic detection of Alzheimer's disease proposed in the context of the INESC-ID Human Language Technology Laboratory participation in the ADReSS 2020 challenge. Our classification…

Audio and Speech Processing · Electrical Eng. & Systems 2020-06-01 Anna Pompili , Thomas Rolland , Alberto Abad

Despite rapid advances in large language models (LLMs), their integration with traditional supervised machine learning (ML) techniques that have proven applicability to medical data remains underexplored. This is particularly true for…

Computation and Language · Computer Science 2025-05-28 Yuxin Zhu , Yuting Guo , Noah Marchuck , Abeed Sarker , Yun Wang

Early diagnosis of Alzheimer's disease (AD) is crucial in facilitating preventive care to delay further progression. This paper presents the development of a state-of-the-art Conformer based speech recognition system built on the…

Audio and Speech Processing · Electrical Eng. & Systems 2022-06-28 Tianzi Wang , Jiajun Deng , Mengzhe Geng , Zi Ye , Shoukang Hu , Yi Wang , Mingyu Cui , Zengrui Jin , Xunying Liu , Helen Meng

Alzheimer's disease (AD) has become one of the most significant health challenges in an aging society. The use of spoken language-based AD detection methods has gained prevalence due to their scalability due to their scalability. Based on…

Computation and Language · Computer Science 2024-12-02 Junan Li , Yunxiang Li , Yuren Wang , Xixin Wu , Helen Meng

This Signal Processing Grand Challenge (SPGC) targets a difficult automatic prediction problem of societal and medical relevance, namely, the detection of Alzheimer's Dementia (AD). Participants were invited to employ signal processing and…

Audio and Speech Processing · Electrical Eng. & Systems 2023-01-16 Saturnino Luz , Fasih Haider , Davida Fromm , Ioulietta Lazarou , Ioannis Kompatsiaris , Brian MacWhinney

Deep learning, a cutting-edge machine learning approach, outperforms traditional machine learning in identifying intricate structures in complex high-dimensional data, particularly in the domain of healthcare. This study focuses on…

Computer Vision and Pattern Recognition · Computer Science 2024-05-21 Nida Nasir , Muneeb Ahmed , Neda Afreen , Mustafa Sameer

Early prediction of Alzheimer's disease (AD) is crucial for timely intervention and treatment. This study aims to use machine learning approaches to analyze longitudinal electronic health records (EHRs) of patients with AD and identify…

Machine Learning · Computer Science 2025-04-29 Rumeng Li , Xun Wang , Dan Berlowitz , Brian Silver , Wen Hu , Heather Keating , Raelene Goodwin , Weisong Liu , Honghuang Lin , Hong Yu

We develop a large language model (LLM) based automatic speech recognition (ASR) system that can be contextualized by providing keywords as prior information in text prompts. We adopt decoder-only architecture and use our in-house LLM,…

Audio and Speech Processing · Electrical Eng. & Systems 2024-10-14 Kento Nozawa , Takashi Masuko , Toru Taniguchi

Alzheimer's disease (AD) and sleep disorders exhibit a close association, where disruptions in sleep patterns often precede the onset of Mild Cognitive Impairment (MCI) and early-stage AD. This study delves into the potential of utilizing…

Alzheimer's disease (AD) is an irreversible brain disease that can dramatically reduce quality of life, most commonly manifesting in older adults and eventually leading to the need for full-time care. Early detection is fundamental to…

Computation and Language · Computer Science 2019-06-14 Flavio Di Palo , Natalie Parde

Pathological speech analysis has been of interest in the detection of certain diseases like depression and Alzheimer's disease and attracts much interest from researchers. However, previous pathological speech analysis models are commonly…

Audio and Speech Processing · Electrical Eng. & Systems 2024-11-08 Fei Yang , Xuenan Xu , Mengyue Wu , Kai Yu

LLM-based automatic speech recognition models demonstrate strong performance by connecting audio encoders and LLMs. However, data scarcity of paired speech and transcription often hinders their adaptation to new domains, making text-only…

Sound · Computer Science 2026-05-15 Ryo Magoshi , Takashi Maekaku , Yusuke Shinohara

Alzheimer's Disease (AD) ravages the cognitive ability of more than 5 million Americans and creates an enormous strain on the health care system. This paper proposes a machine learning predictive model for AD development without medical…

Quantitative Methods · Quantitative Biology 2020-06-17 Courtney Cochrane , David Castineira , Nisreen Shiban , Pavlos Protopapas

Annotating and recognizing speech emotion using prompt engineering has recently emerged with the advancement of Large Language Models (LLMs), yet its efficacy and reliability remain questionable. In this paper, we conduct a systematic study…

Audio and Speech Processing · Electrical Eng. & Systems 2025-05-01 Yuanchao Li , Yuan Gong , Chao-Han Huck Yang , Peter Bell , Catherine Lai

Early and reliable detection of Alzheimer's disease (AD) is crucial for timely clinical intervention and improved patient management. It also supports the evaluation of emerging therapeutic strategies. In this paper, we propose a Low-Rank…

Machine Learning · Computer Science 2026-05-07 Wu Wang , Yuang Cheng , Fouzi Harrou , Ying Sun