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DNA emerges as a promising medium for the exponential growth of digital data due to its density and durability. This study extends recent research by addressing the \emph{coverage depth problem} in practical scenarios, exploring optimal…

Information Theory · Computer Science 2024-02-01 Hadas Abraham , Rayn Gabrys , Eitan Yaakobi

DNA has emerged as a promising alternative for long-term data storage due to its high capacity, durability, and low-energy potential. However, storing data in DNA presents several challenges. First, it requires complex and costly…

Other Quantitative Biology · Quantitative Biology 2025-11-20 Sara Al Sayyed , Aline Roumy , Thomas Maugey

With recent high-throughput technology we can synthesize large heterogeneous collections of DNA structures, and also read them all out precisely in a single procedure. Can we use these tools, not only to do things faster, but also to devise…

Data Structures and Algorithms · Computer Science 2021-12-07 Luca Cardelli

In this review paper, we delve into the nascent field of molecular data storage, focusing on system implementations and code constructions. We start by providing an overview of basic concepts in synthetic and computational biology.…

Emerging Technologies · Computer Science 2023-10-10 Olgica Milenkovic , Chao Pan

Digital information can be encoded in the building-block sequence of macro-molecules, such as RNA and single-stranded DNA. Methods of "writing" and "reading" macromolecular strands are currently available, but they are slow and expensive.…

Emerging Technologies · Computer Science 2017-09-14 Masud Mansuripur , Pramod Khulbe

Due to its longevity and enormous information density, DNA is an attractive medium for archival data storage. Thanks to rapid technological advances, DNA storage is becoming practically feasible, as demonstrated by a number of experimental…

Information Theory · Computer Science 2022-11-11 Ilan Shomorony , Reinhard Heckel

Over the past years, the ever-growing trend on data storage demand, more specifically for "cold" data (rarely accessed data), has motivated research for alternative systems of data storage. Because of its biochemical characteristics,…

Machine Learning · Computer Science 2022-03-21 Xavier Pic , Marc Antonini

The term Big Data is usually used to describe huge amount of data that is generated by humans from digital media such as cameras, internet, phones, sensors etc. By building advanced analytics on the top of big data, one can predict many…

Emerging Technologies · Computer Science 2014-05-19 Shalin Shah , Dixita Limbachiya , Manish K. Gupta

In this paper, we study achievable rates of concatenated coding schemes over a deoxyribonucleic acid (DNA) storage channel. Our channel model incorporates the main features of DNA-based data storage. First, information is stored on many,…

Information Theory · Computer Science 2020-05-04 Andreas Lenz , Lorenz Welter , Sven Puchinger

Owing to its longevity and enormous information density, DNA, the molecule encoding biological information, has emerged as a promising archival storage medium. However, due to technological constraints, data can only be written onto many…

Emerging Technologies · Computer Science 2018-03-12 Reinhard Heckel , Gediminas Mikutis , Robert N. Grass

DNA is an attractive medium for digital data storage. When data is stored on DNA, errors occur, which makes error-correcting coding techniques critical for reliable DNA data storage. To reduce the errors, a common technique is to include…

Information Theory · Computer Science 2024-06-27 Franziska Weindel , Andreas L. Gimpel , Robert N. Grass , Reinhard Heckel

The problem of storing large amounts of information safely for a long period of time has become essential. One of the most promising new data storage mediums are the polymer-based data storage systems, like the DNA-storage system. These…

Information Theory · Computer Science 2025-04-21 Ville Junnila , Tero Laihonen , Tuomo Lehtilä

This paper studies two problems that are motivated by the novel recent approach of composite DNA that takes advantage of the DNA synthesis property which generates a huge number of copies for every synthesized strand. Under this paradigm,…

Information Theory · Computer Science 2025-05-15 Tomer Cohen , Eitan Yaakobi

Although the expenses associated with DNA sequencing have been rapidly decreasing, the current cost of sequencing information stands at roughly $120/GB, which is dramatically more expensive than reading from existing archival storage…

Discrete Mathematics · Computer Science 2023-11-30 Daniella Bar-Lev , Omer Sabary , Ryan Gabrys , Eitan Yaakobi

DNA data storage offers a high-density, long-term alternative to traditional storage systems, addressing the exponential growth of digital data. Composite DNA extends this paradigm by leveraging mixtures of nucleotides to increase storage…

Information Theory · Computer Science 2026-02-13 Busra Tegin , Tolga M Duman

Due to its longevity and enormous information density, DNA is an attractive medium for archival storage. In this work, we study the fundamental limits and trade-offs of DNA-based storage systems by introducing a new channel model, which we…

Information Theory · Computer Science 2020-01-20 Ilan Shomorony , Reinhard Heckel

DNA sequencing is revolutionising the field of medicine. DNA sequencers, the machines which perform DNA sequencing, have evolved from the size of a fridge to that of a mobile phone over the last two decades. The cost of sequencing a human…

Genomics · Quantitative Biology 2021-01-14 Hasindu Gamaarachchi

DNA-based data storage has been attracting significant attention due to its extremely high data storage density, low power consumption, and long duration compared to conventional data storage media. Despite the recent advancements in DNA…

Information Theory · Computer Science 2024-11-12 Yi Ding , Xuan He , Tuan Thanh Nguyen , Wentu Song , Zohar Yakhini , Eitan Yaakobi , Linqiang Pan , Xiaohu Tang , Kui Cai

The main obstacles for the practical deployment of DNA-based data storage platforms are the prohibitively high cost of synthetic DNA and the large number of errors introduced during synthesis. In particular, synthetic DNA products contain…

Image and Video Processing · Electrical Eng. & Systems 2021-01-26 Chao Pan , S. M. Hossein Tabatabaei Yazdi , S Kasra Tabatabaei , Alvaro G. Hernandez , Charles Schroeder , Olgica Milenkovic

DNA is a leading candidate as the next archival storage media due to its density, durability and sustainability. To read (and write) data DNA storage exploits technology that has been developed over decades to sequence naturally occurring…

Emerging Technologies · Computer Science 2022-05-12 Jasmine Quah , Omer Sella , Thomas Heinis