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Deep learning models for natural language processing rely heavily on high-quality labeled datasets. However, existing labeling approaches often struggle to balance label quality with labeling cost. To address this challenge, we propose…

Human-Computer Interaction · Computer Science 2026-02-17 Guozheng Li , Ao Wang , Shaoxiang Wang , Yu Zhang , Pengcheng Cao , Yang Bai , Chi Harold Liu

Pretraining large neural language models, such as BERT, has led to impressive gains on many natural language processing (NLP) tasks. However, most pretraining efforts focus on general domain corpora, such as newswire and Web. A prevailing…

Computation and Language · Computer Science 2021-09-20 Yu Gu , Robert Tinn , Hao Cheng , Michael Lucas , Naoto Usuyama , Xiaodong Liu , Tristan Naumann , Jianfeng Gao , Hoifung Poon

Recent advances in Large Language Models (LLMs) have led to remarkable progresses in medical consultation. However, existing medical LLMs overlook the essential role of Electronic Health Records (EHR) and focus primarily on diagnosis…

Artificial Intelligence · Computer Science 2025-06-26 Weijieying Ren , Tianxiang Zhao , Lei Wang , Tianchun Wang , Vasant Honavar

Large language models (LLMs) are increasingly used as decision-support tools in data-constrained scientific workflows, where correctness and validity are critical. However, evaluation practices often emphasize stability or reproducibility…

Machine Learning · Computer Science 2026-03-18 Nazia Riasat

Recently, Large Language Models (LLM) have demonstrated impressive capability to solve a wide range of tasks. However, despite their success across various tasks, no prior work has investigated their capability in the biomedical domain yet.…

Computation and Language · Computer Science 2024-02-21 Israt Jahan , Md Tahmid Rahman Laskar , Chun Peng , Jimmy Huang

The adoption of machine learning (ML) and deep learning methods has revolutionized molecular medicine by driving breakthroughs in genomics, transcriptomics, drug discovery, and biological systems modeling. The increasing quantity,…

Large language models (LLMs) have notably enhanced the fluency and diversity of machine-generated text. However, this progress also presents a significant challenge in detecting the origin of a given text, and current research on detection…

Computation and Language · Computer Science 2023-10-05 Xianjun Yang , Wei Cheng , Yue Wu , Linda Petzold , William Yang Wang , Haifeng Chen

This paper introduces LalaEval, a holistic framework designed for the human evaluation of domain-specific large language models (LLMs). LalaEval proposes a comprehensive suite of end-to-end protocols that cover five main components…

Human-Computer Interaction · Computer Science 2024-08-27 Chongyan Sun , Ken Lin , Shiwei Wang , Hulong Wu , Chengfei Fu , Zhen Wang

Deep neural networks (DNNs) achieve state-of-the-art results in a variety of domains. Unfortunately, DNNs are notorious for their non-interpretability, and thus limit their applicability in hypothesis-driven domains such as biology and…

Machine Learning · Computer Science 2018-03-12 Chun-Hao Chang , Ladislav Rampasek , Anna Goldenberg

Clinical abnormality grounding for rare diseases is often hindered by data scarcity, making supervised fine-tuning impractical and single-pass inference highly unstable. We propose Dynamic Decision Learning (DDL), a framework that enables…

Computation and Language · Computer Science 2026-04-29 Jun Li , Mingxuan Liu , Jiazhen Pan , Che Liu , Wenjia Bai , Cosmin I. Bercea , Julia A. Schnabel

VLA models have achieved remarkable progress in embodied intelligence; however, their evaluation remains largely confined to simulations or highly constrained real-world settings. This mismatch creates a substantial reality gap, where…

Deep learning (DL) has proven to be a highly effective approach for developing models in diverse contexts, including visual perception, speech recognition, and machine translation. However, the end-to-end process for applying DL is not…

Machine Learning · Computer Science 2022-05-18 Xuanyi Dong , David Jacob Kedziora , Katarzyna Musial , Bogdan Gabrys

Large language models (LLMs) have shown potential in identifying qualitative causal relations, but their ability to perform quantitative causal reasoning -- estimating effect sizes that parametrize functional relationships -- remains…

Recent LLMs have demonstrated remarkable performance in solving exam-like math word problems. However, the degree to which these numerical reasoning skills are effective in real-world scenarios, particularly in expert domains, is still…

Computation and Language · Computer Science 2024-08-12 Yilun Zhao , Yitao Long , Hongjun Liu , Ryo Kamoi , Linyong Nan , Lyuhao Chen , Yixin Liu , Xiangru Tang , Rui Zhang , Arman Cohan

We introduce an expert curated, real-world benchmark for evaluating document-grounded question-answering (QA) motivated by generic drug assessment, using the U.S. Food and Drug Administration (FDA) drug label documents. Drug labels contain…

Computation and Language · Computer Science 2026-03-23 Betty Xiong , Jillian Fisher , Benjamin Newman , Meng Hu , Shivangi Gupta , Yejin Choi , Lanyan Fang , Russ B Altman

Protein Language Models (PLMs) have emerged as performant and scalable tools for predicting the functional impact and clinical significance of protein-coding variants, but they still lag experimental accuracy. Here, we present a novel…

In contrast to their remarkable performance on general knowledge QA, the true abilities of Large Language Models (LLMs) in tasks demanding deep, specialized reasoning, such as in protein biology, have yet to be thoroughly investigated.…

Quantitative Methods · Quantitative Biology 2025-12-30 Dingyi Rong , Zijian Chen , Qi Jia , Kaiwei Zhang , Haotian Lu , Guangtao Zhai , Ning Liu

Reliable evaluation is essential for developing and deploying large language models, yet in practice it often requires substantial manual effort: practitioners must identify appropriate benchmarks, reproduce heterogeneous evaluation…

Computation and Language · Computer Science 2026-03-11 Chengyu Shen , Yanheng Hou , Minghui Pan , Runming He , Zhen Hao Wong , Meiyi Qiang , Zhou Liu , Hao Liang , Peichao Lai , Zeang Sheng , Wentao Zhang

Large Language Models (LLMs) have achieved state-of-the-art performance on a broad range of Natural Language Processing (NLP) tasks, including document processing and code generation. Autoregressive Language Models (ARMs), which generate…

Logic reasoning in natural language has been recognized as an important measure of human intelligence for Large Language Models (LLMs). Popular benchmarks may entangle multiple reasoning skills and thus provide unfaithful evaluations on the…

Computation and Language · Computer Science 2025-09-29 Tsz Ting Chung , Lemao Liu , Mo Yu , Dit-Yan Yeung
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