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Related papers: DART-Eval: A Comprehensive DNA Language Model Eval…

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Pretraining DNA language models (DNALMs) on the full human genome is resource-intensive, yet often considered necessary for strong downstream performance. Inspired by recent findings in NLP and long-context modeling, we explore an…

Genomics · Quantitative Biology 2025-06-24 Sohan Mupparapu , Parameswari Krishnamurthy , Ratish Puduppully

The genome sequence contains the blueprint for governing cellular processes. While the availability of genomes has vastly increased over the last decades, experimental annotation of the various functional, non-coding and regulatory elements…

Genomics · Quantitative Biology 2024-04-10 Frederikke Isa Marin , Felix Teufel , Marc Horlacher , Dennis Madsen , Dennis Pultz , Ole Winther , Wouter Boomsma

Large Language Models (LLMs) have demonstrated promising reasoning capabilities in robotics; however, their application in multi-robot systems remains limited, particularly in handling task dependencies. This paper introduces DART-LLM, a…

Large language models (LLMs) have achieved remarkable performance in various evaluation benchmarks. However, concerns are raised about potential data contamination in their considerable volume of training corpus. Moreover, the static nature…

Artificial Intelligence · Computer Science 2024-03-15 Kaijie Zhu , Jiaao Chen , Jindong Wang , Neil Zhenqiang Gong , Diyi Yang , Xing Xie

Early DNA foundation models adopted BERT-style training, achieving good performance on DNA understanding tasks but lacking generative capabilities. Recent autoregressive models enable DNA generation, but employ left-to-right causal modeling…

Machine Learning · Computer Science 2026-03-03 Zhao Yang , Hengchang Liu , Chuan Cao , Bing Su

Large language models (LLMs) have shown remarkable reasoning capabilities, yet aligning such abilities to small language models (SLMs) remains a challenge due to distributional mismatches and limited model capacity. Existing reasoning…

Computation and Language · Computer Science 2025-05-28 Yong Wu , Weihang Pan , Ke Li , Chen Binhui , Ping Li , Binbin Lin

Foundation models have revolutionized natural language processing and artificial intelligence, significantly enhancing how machines comprehend and generate human languages. Inspired by the success of these foundation models, researchers…

Predicting gene function from its DNA sequence is a fundamental challenge in biology. Many deep learning models have been proposed to embed DNA sequences and predict their enzymatic function, leveraging information in public databases…

The extraction of pharmacological knowledge from regulatory documents has become a key focus in biomedical natural language processing, with applications ranging from adverse event monitoring to AI-assisted clinical decision support.…

Computation and Language · Computer Science 2025-10-22 Mariano Barone , Antonio Laudante , Giuseppe Riccio , Antonio Romano , Marco Postiglione , Vincenzo Moscato

The current paradigm of evaluating Large Language Models (LLMs) through static benchmarks comes with significant limitations, such as vulnerability to data contamination and a lack of adaptability to the evolving capabilities of LLMs.…

Computation and Language · Computer Science 2024-06-26 Zhehao Zhang , Jiaao Chen , Diyi Yang

We introduce Mathador-LM, a new benchmark for evaluating the mathematical reasoning on large language models (LLMs), combining ruleset interpretation, planning, and problem-solving. This benchmark is inspired by the Mathador game, where the…

Computation and Language · Computer Science 2024-10-16 Eldar Kurtic , Amir Moeini , Dan Alistarh

Large language models (LLMs) trained on text demonstrated remarkable results on natural language processing (NLP) tasks. These models have been adapted to decipher the language of DNA, where sequences of nucleotides act as "words" that…

Natural Language Understanding (NLU) is a basic task in Natural Language Processing (NLP). The evaluation of NLU capabilities has become a trending research topic that attracts researchers in the last few years, resulting in the development…

Computation and Language · Computer Science 2025-07-29 Khloud AL Jallad , Nada Ghneim , Ghaida Rebdawi

As key elements within the central dogma, DNA, RNA, and proteins play crucial roles in maintaining life by guaranteeing accurate genetic expression and implementation. Although research on these molecules has profoundly impacted fields like…

Diffusion language models (DLMs) have emerged as a promising paradigm for large language models (LLMs), yet the non-deterministic behavior of DLMs remains poorly understood. The existing non-determinism evaluations for LLMs predominantly…

Machine Learning · Computer Science 2026-04-16 Zhengyu Fang , Zhimeng Jiang , Huiyuan Chen , Xiaoge Zhang , Tianyi Li , Kaiyu Tang , Xiao Li , Jing Li

Large Language Models (LLMs) encounter challenges with the unique syntax of specific domains, such as biomolecules. Existing fine-tuning or modality alignment techniques struggle to bridge the domain knowledge gap and understand complex…

Biomolecules · Quantitative Biology 2024-06-28 Jinzhe Liu , Xiangsheng Huang , Zhuo Chen , Yin Fang

In the era of data-driven decision-making, the complexity of data analysis necessitates advanced expertise and tools of data science, presenting significant challenges even for specialists. Large Language Models (LLMs) have emerged as…

Artificial Intelligence · Computer Science 2024-02-28 Yuge Zhang , Qiyang Jiang , Xingyu Han , Nan Chen , Yuqing Yang , Kan Ren

Although DNA foundation models have advanced the understanding of genomes, they still face significant challenges in the limited scale and diversity of genomic data. This limitation starkly contrasts with the success of natural language…

Genomics · Quantitative Biology 2024-02-14 Huixin Zhan , Ying Nian Wu , Zijun Zhang

The emergence of Large Language Models (LLMs) has shifted language model evaluation toward reasoning and problem-solving tasks as measures of general intelligence. Small Language Models (SLMs) -- defined here as models under 10B parameters…

Computation and Language · Computer Science 2026-01-08 Gabriel Benedict , Matthew Butler , Naved Merchant , Eetu Salama-Laine

Unlocking deep and interpretable biological reasoning from complex genomic data remains a major AI challenge limiting scientific progress. While current DNA foundation models excel at representing sequences, they struggle with multi-step…

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