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Existing benchmarks for evaluating mathematical reasoning in large language models (LLMs) rely primarily on competition problems, formal proofs, or artificially challenging questions -- failing to capture the nature of mathematics…

Artificial Intelligence · Computer Science 2025-10-21 Jie Zhang , Cezara Petrui , Kristina Nikolić , Florian Tramèr

Solving mathematical problems requires advanced reasoning abilities and presents notable challenges for large language models. Previous works usually synthesize data from proprietary models to augment existing datasets, followed by…

Computation and Language · Computer Science 2024-12-24 Yuxuan Tong , Xiwen Zhang , Rui Wang , Ruidong Wu , Junxian He

The leaderboard of Large Language Models (LLMs) in mathematical tasks has been continuously updated. However, the majority of evaluations focus solely on the final results, neglecting the quality of the intermediate steps. This oversight…

Computation and Language · Computer Science 2025-01-15 Shijie Xia , Xuefeng Li , Yixin Liu , Tongshuang Wu , Pengfei Liu

At the intersection of the rapidly growing biological data landscape and advancements in Natural Language Processing (NLP), protein language models (PLMs) have emerged as a transformative force in modern research. These models have achieved…

Biomolecules · Quantitative Biology 2025-02-12 Lei Wang , Xudong Li , Han Zhang , Jinyi Wang , Dingkang Jiang , Zhidong Xue , Yan Wang

We introduce DA-Code, a code generation benchmark specifically designed to assess LLMs on agent-based data science tasks. This benchmark features three core elements: First, the tasks within DA-Code are inherently challenging, setting them…

Computation and Language · Computer Science 2024-10-14 Yiming Huang , Jianwen Luo , Yan Yu , Yitong Zhang , Fangyu Lei , Yifan Wei , Shizhu He , Lifu Huang , Xiao Liu , Jun Zhao , Kang Liu

Large language models have achieved remarkable success on general NLP tasks, but they may fall short for domain-specific problems. Recently, various Retrieval-Augmented Large Language Models (RALLMs) are proposed to address this…

Computation and Language · Computer Science 2024-06-18 Shangqing Tu , Yuanchun Wang , Jifan Yu , Yuyang Xie , Yaran Shi , Xiaozhi Wang , Jing Zhang , Lei Hou , Juanzi Li

Large language models (LLMs) face significant challenges when processing complex rule systems, as they typically treat interdependent rules as unstructured textual data rather than as logically organized frameworks. This limitation results…

Inspired by the success of large language models (LLM) for DNA and proteins, several LLM for RNA have been developed recently. RNA-LLM uses large datasets of RNA sequences to learn, in a self-supervised way, how to represent each RNA base…

Artificial Intelligence · Computer Science 2025-02-04 L. I. Zablocki , L. A. Bugnon , M. Gerard , L. Di Persia , G. Stegmayer , D. H. Milone

The fast-growing demands in using Large Language Models (LLMs) to tackle complex multi-step data science tasks create an emergent need for accurate benchmarking. There are two major gaps in existing benchmarks: (i) the lack of standardized,…

Artificial Intelligence · Computer Science 2026-03-02 Fan Shu , Yite Wang , Ruofan Wu , Boyi Liu , Zhewei Yao , Yuxiong He , Feng Yan

Large-scale Vision-Language Models (VLMs) have achieved notable progress in aligning visual inputs with text. However, their ability to deeply understand the unique physical properties of non-RGB vision sensor images remains limited. In…

Computer Vision and Pattern Recognition · Computer Science 2025-08-04 Sangyun Chung , Youngjoon Yu , Se Yeon Kim , Youngchae Chee , Yong Man Ro

There are already many DNA large language models, but most of them still follow traditional uses, such as extracting sequence features for classification tasks. More innovative applications of large language models, such as prompt…

Genomics · Quantitative Biology 2024-10-29 Wang Liang

Every major data modality now has a foundation model that understands it natively: text has language models, images have vision models, audio has audio models. Tabular data, the modality on which many consequential real-world AI decisions…

Artificial Intelligence · Computer Science 2026-05-08 Eda Erol , Giuliano Pezzoli , Ozer Cem Kelahmet

Several recent works seek to develop foundation models specifically for medical applications, adapting general-purpose large language models (LLMs) and vision-language models (VLMs) via continued pretraining on publicly available biomedical…

Computation and Language · Computer Science 2024-11-21 Daniel P. Jeong , Saurabh Garg , Zachary C. Lipton , Michael Oberst

Large language models for code (i.e., code LLMs) have shown strong code understanding and generation capabilities. To evaluate the capabilities of code LLMs in various aspects, many benchmarks have been proposed (e.g., HumanEval and…

Software Engineering · Computer Science 2024-09-24 Junkai Chen , Zhiyuan Pan , Xing Hu , Zhenhao Li , Ge Li , Xin Xia

Pre-trained large language models demonstrate potential in extracting information from DNA sequences, yet adapting to a variety of tasks and data modalities remains a challenge. To address this, we propose DNAGPT, a generalized DNA…

Genomics · Quantitative Biology 2023-09-01 Daoan Zhang , Weitong Zhang , Yu Zhao , Jianguo Zhang , Bing He , Chenchen Qin , Jianhua Yao

Large Language Models (LLMs) have revolutionized both general natural language processing and domain-specific applications such as code synthesis, legal reasoning, and finance. However, while prior studies have explored individual model…

Software Engineering · Computer Science 2025-12-05 Gunjan Das , Paheli Bhattacharya , Rishabh Gupta

Data attribution methods quantify the influence of training data on model outputs and are becoming increasingly relevant for a wide range of LLM research and applications, including dataset curation, model interpretability, data valuation.…

Computation and Language · Computer Science 2025-10-28 Cathy Jiao , Yijun Pan , Emily Xiao , Daisy Sheng , Niket Jain , Hanzhang Zhao , Ishita Dasgupta , Jiaqi W. Ma , Chenyan Xiong

Evaluation is the baton for the development of large language models. Current evaluations typically employ a single-item assessment paradigm for each atomic test objective, which struggles to discern whether a model genuinely possesses the…

Computation and Language · Computer Science 2024-08-08 Boxi Cao , Mengjie Ren , Hongyu Lin , Xianpei Han , Feng Zhang , Junfeng Zhan , Le Sun

In the genome biology research, regulatory genome modeling is an important topic for many regulatory downstream tasks, such as promoter classification, transaction factor binding sites prediction. The core problem is to model how regulatory…

Genomics · Quantitative Biology 2021-11-04 Shentong Mo , Xi Fu , Chenyang Hong , Yizhen Chen , Yuxuan Zheng , Xiangru Tang , Zhiqiang Shen , Eric P Xing , Yanyan Lan

General large language models enhanced with supervised fine-tuning and reinforcement learning from human feedback are increasingly popular in academia and industry as they generalize foundation models to various practical tasks in a prompt…

Computation and Language · Computer Science 2024-06-18 Shiguo Lian , Kaikai Zhao , Xinhui Liu , Xuejiao Lei , Bikun Yang , Wenjing Zhang , Kai Wang , Zhaoxiang Liu