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Synthetic medical data which preserves privacy while maintaining utility can be used as an alternative to real medical data, which has privacy costs and resource constraints associated with it. At present, most models focus on generating…

Machine Learning · Computer Science 2019-11-28 Saloni Dash , Ritik Dutta , Isabelle Guyon , Adrien Pavao , Andrew Yale , Kristin P. Bennett

Clinical natural language processing requires methods that can address domain-specific challenges, such as complex medical terminology and clinical contexts. Recently, large language models (LLMs) have shown promise in this domain. Yet,…

Computation and Language · Computer Science 2025-01-28 Ran Xu , Hejie Cui , Yue Yu , Xuan Kan , Wenqi Shi , Yuchen Zhuang , Wei Jin , Joyce Ho , Carl Yang

The rapid advancement of large language models (LLMs) has sparked interest in data synthesis techniques, aiming to generate diverse and high-quality synthetic datasets. However, these synthetic datasets often suffer from a lack of diversity…

Computation and Language · Computer Science 2024-08-09 Himanshu Gupta , Kevin Scaria , Ujjwala Anantheswaran , Shreyas Verma , Mihir Parmar , Saurabh Arjun Sawant , Chitta Baral , Swaroop Mishra

The development of robust clinical decision support systems is frequently impeded by the scarcity of high-fidelity, privacy-preserving biomedical data. While Generative Large Language Models (LLMs) offer a promising avenue for synthetic…

Machine Learning · Computer Science 2026-04-03 Arshia Ilaty , Hossein Shirazi , Amir Rahmani , Hajar Homayouni

Access to electronic health record (EHR) data has motivated computational advances in medical research. However, various concerns, particularly over privacy, can limit access to and collaborative use of EHR data. Sharing synthetic EHR data…

Machine Learning · Computer Science 2018-01-15 Edward Choi , Siddharth Biswal , Bradley Malin , Jon Duke , Walter F. Stewart , Jimeng Sun

This paper explores the use of large language models (LLMs) to assist in the development of new disease modules for Synthea, an open-source synthetic health data generator. Incorporating LLMs into the module development process has the…

Artificial Intelligence · Computer Science 2025-07-30 Mark A. Kramer , Aanchal Mathur , Caroline E. Adams , Jason A. Walonoski

Despite recent success in applying large language models (LLMs) to electronic health records (EHR), most systems focus primarily on assessment rather than treatment planning. We identify three critical limitations in current approaches:…

Class imbalance can often degrade predictive performance of supervised learning algorithms. Balanced classes can be obtained by oversampling exact copies, with noise, or interpolation between nearest neighbours (as in traditional SMOTE…

Machine Learning · Computer Science 2022-01-17 Emily Muller , Xu Zheng , Jer Hayes

Large-scale clinical data is invaluable to driving many computational scientific advances today. However, understandable concerns regarding patient privacy hinder the open dissemination of such data and give rise to suboptimal siloed…

Computation and Language · Computer Science 2019-05-23 Oren Melamud , Chaitanya Shivade

Large Language Models (LLMs) such as GPT-4 and Llama3 have significantly impacted various fields by enabling high-quality synthetic data generation and reducing dependence on expensive human-generated datasets. Despite this, challenges…

Computation and Language · Computer Science 2025-11-18 Yue Huang , Siyuan Wu , Chujie Gao , Dongping Chen , Qihui Zhang , Yao Wan , Tianyi Zhou , Jianfeng Gao , Chaowei Xiao , Lichao Sun , Xiangliang Zhang

Generative modelling has become the standard approach for synthesising tabular data. However, different use cases demand synthetic data to comply with different requirements to be useful in practice. In this survey, we review deep…

Machine Learning · Computer Science 2026-03-17 Mihaela Cătălina Stoian , Eleonora Giunchiglia , Thomas Lukasiewicz

Federated learning (FL) enables training large language models (LLMs) without sharing raw data, but adapting LLMs under strict data isolation and non-IID client distributions remains challenging in practice. Synthetic data offers a natural…

In recent years, with the rapid advancements in large language models (LLMs), achieving excellent empathetic response capabilities has become a crucial prerequisite. Consequently, managing and understanding empathetic datasets have gained…

Computation and Language · Computer Science 2024-08-13 Hao Liang , Linzhuang Sun , Jingxuan Wei , Xijie Huang , Linkun Sun , Bihui Yu , Conghui He , Wentao Zhang

The success of large language models (LLMs) facilitate many parties to fine-tune LLMs on their own private data. However, this practice raises privacy concerns due to the memorization of LLMs. Existing solutions, such as utilizing synthetic…

Cryptography and Security · Computer Science 2024-10-11 Wenhao Wang , Xiaoyu Liang , Rui Ye , Jingyi Chai , Siheng Chen , Yanfeng Wang

Tabular data synthesis is crucial in machine learning, yet existing general methods-primarily based on statistical or deep learning models-are highly data-dependent and often fall short in recommender systems. This limitation arises from…

Information Retrieval · Computer Science 2025-02-12 Jingtong Gao , Zhaocheng Du , Xiaopeng Li , Yichao Wang , Xiangyang Li , Huifeng Guo , Ruiming Tang , Xiangyu Zhao

Generating tabular data under differential privacy (DP) protection ensures theoretical privacy guarantees but poses challenges for training machine learning models, primarily due to the need to capture complex structures under noisy…

Machine Learning · Computer Science 2025-04-30 Tejumade Afonja , Hui-Po Wang , Raouf Kerkouche , Mario Fritz

Analyzing medical data to find abnormalities is a time-consuming and costly task, particularly for rare abnormalities, requiring tremendous efforts from medical experts. Artificial intelligence has become a popular tool for the automatic…

Access to real-world medication prescriptions is essential for medical research and healthcare quality improvement. However, access to real medication prescriptions is often limited due to the sensitive nature of the information expressed.…

Computation and Language · Computer Science 2023-11-21 Samuel Belkadi , Nicolo Micheletti , Lifeng Han , Warren Del-Pinto , Goran Nenadic

Synthetic data generation (SDG) is a promising approach for enabling data sharing in biomedical studies while preserving patient privacy. Yet, state-of-the-art generative models often require large datasets and complex training procedures,…

Machine Learning · Computer Science 2026-01-27 Natalia Espinosa-Dice , Nicholas J. Jackson , Chao Yan , Aaron Lee , Bradley A. Malin

This work presents a systematic benchmark of differentially private synthetic data generation algorithms that can generate tabular data. Utility of the synthetic data is evaluated by measuring whether the synthetic data preserve the…

Cryptography and Security · Computer Science 2022-02-16 Yuchao Tao , Ryan McKenna , Michael Hay , Ashwin Machanavajjhala , Gerome Miklau
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