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A new three-dimensional (3D) multiphase computational fluid dynamics (CFD) model for adsorption physics in packed beds of spherical beads is developed and validated. The model is constituted at a macroscopic scale that integrates new…

Fluid Dynamics · Physics 2026-03-24 Mohamad Najib Nadamani , Mostafa Safdari Shadloo , Talib Dbouk

Cardiac biosignals, such as electrocardiograms (ECG) and photoplethysmograms (PPG), are of paramount importance for the diagnosis, prevention, and management of cardiovascular diseases, and have been extensively used in a variety of…

Coronary artery disease (CAD) remains the leading cause of death globally and invasive coronary angiography (ICA) is considered the gold standard of anatomical imaging evaluation when CAD is suspected. However, risk evaluation based on ICA…

In numerical simulations of cardiac mechanics, coupling the heart to a model of the circulatory system is essential for capturing physiological cardiac behavior. A popular and efficient technique is to use an electrical circuit analogy,…

Large prospective epidemiological studies acquire cardiovascular magnetic resonance (CMR) images for pre-symptomatic populations and follow these over time. To support this approach, fully automatic large-scale 3D analysis is essential. In…

Image and Video Processing · Electrical Eng. & Systems 2019-07-04 Rahman Attar , Marco Pereanez , Christopher Bowles , Stefan K. Piechnik , Stefan Neubauer , Steffen E. Petersen , Alejandro F. Frangi

Cardiovascular disease is the leading global cause of mortality, with coronary artery disease (CAD) as its most prevalent form, necessitating early risk prediction. While 3D coronary artery digital twins reconstructed from imaging offer…

Self-supervised learning is crucial for clinical imaging applications, given the lack of explicit labels in healthcare. However, conventional approaches that rely on precise vision-language alignment are not always feasible in complex…

Computer Vision and Pattern Recognition · Computer Science 2023-04-18 Jielin Qiu , Peide Huang , Makiya Nakashima , Jaehyun Lee , Jiacheng Zhu , Wilson Tang , Pohao Chen , Christopher Nguyen , Byung-Hak Kim , Debbie Kwon , Douglas Weber , Ding Zhao , David Chen

Rapid and accurate simulation of cerebral aneurysm flow modifications by flow diverters (FDs) can help improving patient-specific intervention and predicting treatment outcome. However, with explicit FD devices being placed in…

Detection and monitoring of patients with pulmonary hypertension, defined as mean blood pressure in the main pulmonary artery above 25 mmHg, requires a combination of imaging and hemodynamic measurements. This study demonstrates how to…

Quantitative Methods · Quantitative Biology 2020-02-21 Megan J. Chambers , Mitchel J. Colebank , M Umar Qureshi , Rachel Clipp , Mette S. Olufsen

Multiphase flow phenomena have been widely observed in the industrial applications, yet it remains a challenging unsolved problem. Three-dimensional computational fluid dynamics (CFD) approaches resolve of the flow fields on finer spatial…

Fluid Dynamics · Physics 2020-05-11 Han Bao , Jinyong Feng , Nam Dinh , Hongbin Zhang

We present a novel mathematical model that simulates myocardial blood perfusion by embedding multiscale and multiphysics features. Our model incorporates cardiac electrophysiology, active and passive mechanics, hemodynamics, reduced valve…

Computational Engineering, Finance, and Science · Computer Science 2023-03-27 Alberto Zingaro , Christian Vergara , Luca Dede' , Francesco Regazzoni , Alfio Quarteroni

Recovering the 3D motion of the heart from cine cardiac magnetic resonance (CMR) imaging enables the assessment of regional myocardial function and is important for understanding and analyzing cardiovascular disease. However, 3D cardiac…

Image and Video Processing · Electrical Eng. & Systems 2022-08-02 Qingjie Meng , Chen Qin , Wenjia Bai , Tianrui Liu , Antonio de Marvao , Declan P O'Regan , Daniel Rueckert

Image-based modeling is essential for understanding cardiovascular hemodynamics and advancing the diagnosis and treatment of cardiovascular diseases. Constructing patient-specific vascular models remains labor-intensive, error-prone, and…

Computer Vision and Pattern Recognition · Computer Science 2025-03-18 Pan Du , Delin An , Chaoli Wang , Jian-Xun Wang

In patients with obstructive coronary artery disease, the functional significance of a coronary artery stenosis needs to be determined to guide treatment. This is typically established through fractional flow reserve (FFR) measurement,…

Image and Video Processing · Electrical Eng. & Systems 2019-11-12 Majd Zreik , Robbert W. van Hamersvelt , Nadieh Khalili , Jelmer M. Wolterink , Michiel Voskuil , Max A. Viergever , Tim Leiner , Ivana Išgum

Computational fluid dynamics (CFD) is a valuable asset for patient-specific cardiovascular-disease diagnosis and prognosis, but its high computational demands hamper its adoption in practice. Machine-learning methods that estimate blood…

Machine Learning · Computer Science 2024-06-18 Julian Suk , Pim de Haan , Phillip Lippe , Christoph Brune , Jelmer M. Wolterink

Treatment of patients with obstructive coronary artery disease is guided by the functional significance of a coronary artery stenosis. Fractional flow reserve (FFR), measured during invasive coronary angiography (ICA), is considered the…

Image and Video Processing · Electrical Eng. & Systems 2019-11-13 Majd Zreik , Tim Leiner , Nadieh Khalili , Robbert W. van Hamersvelt , Jelmer M. Wolterink , Michiel Voskuil , Max A. Viergever , Ivana Išgum

Coronary Artery Disease (CAD) remains a leading cause of morbidity and mortality worldwide. Early detection is critical to recover patient outcomes and decrease healthcare costs. In recent years, machine learning (ML) advancements have…

Artificial Intelligence · Computer Science 2026-03-10 Karan Kumar Singh , Nikita Gajbhiye , Gouri Sankar Mishra

The Multi-Purpose Detector (MPD) at NICA collider has a substantial discovery potential concerning the exploration of the QCD phase diagram in the region of high net-baryon densities and moderate temperatures. The anisotropic transverse…

High Energy Physics - Experiment · Physics 2019-05-01 Petr Parfenov , Arkadiy Taranenko , Ilya Selyuzhenkov , Peter Senger

Optical imaging of blood flow yields critical functional insights into the circulatory system, but its clinical implementation has typically been limited to shallow depths (~1 millimeter) due to light scattering in biological tissue. Here,…

Medical Physics · Physics 2024-06-25 Yang Zhang , Joshua Olick-Gibson , Karteekeya Sastry , Lihong V. Wang

Computational fluid dynamics (CFD) is a valuable tool for personalised, non-invasive evaluation of hemodynamics in arteries, but its complexity and time-consuming nature prohibit large-scale use in practice. Recently, the use of deep…

Machine Learning · Computer Science 2022-01-21 Julian Suk , Pim de Haan , Phillip Lippe , Christoph Brune , Jelmer M. Wolterink