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Peptides are biomolecules comprised of amino acids that play an important role in our body. In recent years, peptides have received extensive attention in drug design and synthesis, and peptide prediction tasks help us better search for…

Machine Learning · Computer Science 2024-11-26 Zengzhu Guo , Zhiqi Ma

Physics simulations have become fundamental tools to study myriad engineering systems. As physics simulations often involve simplifications, their outputs should be calibrated using real-world data. In this paper, we present a…

Computation · Statistics 2025-08-25 Naichen Shi , Hao Yan , Shenghan Guo , Raed Al Kontar

Partial differential equations (PDEs) play a central role in describing many physical phenomena. Various scientific and engineering applications demand a versatile and differentiable PDE solver that can quickly generate solutions with…

Machine learning for scientific applications faces the challenge of limited data. We propose a framework that leverages a priori known physics to reduce overfitting when training on relatively small datasets. A deep neural network is…

Machine Learning · Computer Science 2019-11-22 Jonathan B. Freund , Jonathan F. MacArt , Justin Sirignano

Recent developments in many-body potential energy representation via deep learning have brought new hopes to addressing the accuracy-versus-efficiency dilemma in molecular simulations. Here we describe DeePMD-kit, a package written in…

Computational Physics · Physics 2018-05-23 Han Wang , Linfeng Zhang , Jiequn Han , Weinan E

Generating photos satisfying multiple constraints find broad utility in the content creation industry. A key hurdle to accomplishing this task is the need for paired data consisting of all modalities (i.e., constraints) and their…

Computer Vision and Pattern Recognition · Computer Science 2023-04-21 Nithin Gopalakrishnan Nair , Wele Gedara Chaminda Bandara , Vishal M. Patel

Diffusion models offer stable training and state-of-the-art performance for deep generative modeling tasks. Here, we consider their use in the context of multivariate subsurface modeling and probabilistic inversion. We first demonstrate…

Computer Vision and Pattern Recognition · Computer Science 2026-01-28 Roberto Miele , Niklas Linde

Partial differential equations (PDEs) are central to describing and modelling complex physical systems that arise in many disciplines across science and engineering. However, in many realistic applications PDE modelling provides an…

Machine Learning · Computer Science 2023-04-04 Nacime Bouziani , David A. Ham

This study introduces a hybrid fluid simulation approach that integrates generative diffusion models with physics-based simulations, aiming at reducing the computational costs of flow simulations while still honoring all the physical…

Computing has revolutionised the study of complex nonlinear systems, both by allowing us to solve previously intractable models and through the ability to visualise solutions in different ways. Using ubiquitous computing infrastructure, we…

Physics Education · Physics 2023-10-18 Benjamin J. Walker , Adam K. Townsend , Alexander K. Chudasama , Andrew L. Krause

In this paper, we present a novel research software, called PEGASE, suitable for the design, validation and deployment of advanced control strategies for complex multi-domain energy systems. PEGASE especially features a highly efficient…

Multiphysics phenomena, the coupling effects involving different aspects of physics laws, are pervasive in the real world and can often be encountered when performing everyday household tasks. Intelligent agents which seek to assist or…

Robotics · Computer Science 2023-05-16 Haoyuan Fu , Wenqiang Xu , Ruolin Ye , Han Xue , Zhenjun Yu , Tutian Tang , Yutong Li , Wenxin Du , Jieyi Zhang , Cewu Lu

Collsionless astrophysical and space plasmas cover regions that typically display a separation of scales that exceeds any code's capabilities. To help address this problem, the muphyII code utilizes a hierarchy of models with different…

Computational Physics · Physics 2024-01-23 Florian Allmann-Rahn , Simon Lautenbach , Magnus Deisenhofer , Rainer Grauer

Solving high-dimensional partial differential equations (PDEs) efficiently requires handling multi-scale features across varying resolutions. To address this challenge, we present the Multiwavelet-based Multigrid Neural Operator (M2NO), a…

Machine Learning · Computer Science 2025-12-15 Zhihao Li , Zhilu Lai , Xiaobo Zhang , Wei Wang

Modeling complex spatiotemporal dynamical systems, such as the reaction-diffusion processes, have largely relied on partial differential equations (PDEs). However, due to insufficient prior knowledge on some under-explored dynamical…

Machine Learning · Computer Science 2023-05-23 Chengping Rao , Pu Ren , Qi Wang , Oral Buyukozturk , Hao Sun , Yang Liu

Large text-guided diffusion models, such as DALLE-2, are able to generate stunning photorealistic images given natural language descriptions. While such models are highly flexible, they struggle to understand the composition of certain…

Computer Vision and Pattern Recognition · Computer Science 2023-01-18 Nan Liu , Shuang Li , Yilun Du , Antonio Torralba , Joshua B. Tenenbaum

Dense suspensions of particles dispersed in liquids are central to industrial and geophysical processes and serve as model systems for out-of-equilibrium soft matter. At high particle concentrations, they exhibit stress-dependent rheology,…

Soft Condensed Matter · Physics 2026-03-16 Orhun Ayar , Bhargav Sriram Siddani , Ishan Srivastava , Abhinendra Singh

Dynamic Mode Decomposition (DMD) is an unsupervised machine learning method that has attracted considerable attention in recent years owing to its equation-free structure, ability to easily identify coherent spatio-temporal structures in…

Machine Learning · Computer Science 2022-02-16 Alex Viguerie , Gabriel F. Barros , Malú Grave , Alessandro Reali , Alvaro L. G. A. Coutinho

Solving parametric Partial Differential Equations (PDEs) for a broad range of parameters is a critical challenge in scientific computing. To this end, neural operators, which \textcolor{black}{predicts the PDE solution with variable PDE…

Numerical Analysis · Mathematics 2024-11-14 Weiheng Zhong , Hadi Meidani

The multipole-expansion (MPE) model is an implicit solvation model used to efficiently incorporate solvent effects in quantum chemistry. Even within the recent direct approach, the multipole basis used in MPE to express the dielectric…

Chemical Physics · Physics 2021-12-10 Jakob Filser , Karsten Reuter , Harald Oberhofer