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There are already many DNA large language models, but most of them still follow traditional uses, such as extracting sequence features for classification tasks. More innovative applications of large language models, such as prompt…

Genomics · Quantitative Biology 2024-10-29 Wang Liang

Proprietary Large Language Models (LLMs), such as ChatGPT, have garnered significant attention due to their exceptional capabilities in handling a diverse range of tasks. Recent studies demonstrate that open-sourced smaller foundational…

Computation and Language · Computer Science 2023-10-10 Yue Zhang , Leyang Cui , Deng Cai , Xinting Huang , Tao Fang , Wei Bi

Large Language Models (LLMs), particularly those similar to ChatGPT, have significantly influenced the field of Natural Language Processing (NLP). While these models excel in general language tasks, their performance in domain-specific…

Computation and Language · Computer Science 2024-01-02 Omid Rohanian , Mohammadmahdi Nouriborji , David A. Clifton

Large language models (LLMs) demonstrate promising translation performance among various natural languages. However, many LLMs especially the open-sourced ones, such as BLOOM and LLaMA, are English-dominant and support only dozens of…

Computation and Language · Computer Science 2023-11-22 Wen Yang , Chong Li , Jiajun Zhang , Chengqing Zong

In recent years, large language models (LLMs) have achieved state-of-the-art results in various biological sequence analysis tasks, such as sequence classification, structure prediction, and function prediction. Similar to advancements in…

Genomics · Quantitative Biology 2025-02-19 Wang Liang

Phenotype-driven gene prioritization is a critical process in the diagnosis of rare genetic disorders for identifying and ranking potential disease-causing genes based on observed physical traits or phenotypes. While traditional approaches…

Quantitative Methods · Quantitative Biology 2024-04-04 Junyoung Kim , Jingye Yang , Kai Wang , Chunhua Weng , Cong Liu

Large language models (LLMs) such as ChatGPT have gained considerable interest across diverse research communities. Their notable ability for text completion and generation has inaugurated a novel paradigm for language-interfaced problem…

Quantitative Methods · Quantitative Biology 2024-02-22 Hengchuang Yin , Zhonghui Gu , Fanhao Wang , Yiparemu Abuduhaibaier , Yanqiao Zhu , Xinming Tu , Xian-Sheng Hua , Xiao Luo , Yizhou Sun

Large-scale Pretrained Language Models (LLMs), such as ChatGPT and GPT4, have shown strong abilities in multilingual translations, without being explicitly trained on parallel corpora. It is interesting how the LLMs obtain their ability to…

Computation and Language · Computer Science 2024-04-16 Jiahuan Li , Hao Zhou , Shujian Huang , Shanbo Cheng , Jiajun Chen

The future development of an AI scientist, a tool that is capable of integrating a variety of experimental data and generating testable hypotheses, holds immense potential. So far, bespoke machine learning models have been created to…

Quantitative Methods · Quantitative Biology 2024-03-05 Tyler D. Ross , Ashwin Gopinath

Recent efforts have evaluated large language models (LLMs) in areas such as commonsense reasoning, mathematical reasoning, and code generation. However, to the best of our knowledge, no work has specifically investigated the performance of…

Computation and Language · Computer Science 2024-05-17 Xuanfan Ni , Piji Li

Recent advancements in large language models (LLMs) like ChatGPT and LLaMA show promise in medical applications, yet challenges remain in medical language comprehension. This study presents Me-LLaMA, a new medical LLM family based on…

This study proposes a large language model optimization method based on the improved LoRA fine-tuning algorithm, aiming to improve the accuracy and computational efficiency of the model in natural language processing tasks. We fine-tune the…

Computation and Language · Computer Science 2024-12-30 Jiacheng Hu , Xiaoxuan Liao , Jia Gao , Zhen Qi , Hongye Zheng , Chihang Wang

Random Number Generation Tasks (RNGTs) are used in psychology for examining how humans generate sequences devoid of predictable patterns. By adapting an existing human RNGT for an LLM-compatible environment, this preliminary study tests…

Artificial Intelligence · Computer Science 2024-08-21 Rachel M. Harrison

Pre-trained large language models(LLMs) have attracted increasing attention in biomedical domains due to their success in natural language processing. However, the complex traits and heterogeneity of multi-sources genomics data pose…

Computation and Language · Computer Science 2025-11-25 Yanjun Lyu , Zihao Wu , Lu Zhang , Jing Zhang , Yiwei Li , Wei Ruan , Zhengliang Liu , Zeyu Zhang , Xiang Li , Rongjie Liu , Chao Huang , Wentao Li , Tianming Liu , Dajiang Zhu

Over the last few years, large language models (LLMs) have emerged as the most important breakthroughs in natural language processing (NLP) that fundamentally transform research and developments in the field. ChatGPT represents one of the…

Computation and Language · Computer Science 2023-04-13 Viet Dac Lai , Nghia Trung Ngo , Amir Pouran Ben Veyseh , Hieu Man , Franck Dernoncourt , Trung Bui , Thien Huu Nguyen

Large language models, pivotal in artificial intelligence, find diverse applications. ChatGPT (Chat Generative Pre-trained Transformer), an OpenAI creation, stands out as a widely adopted, powerful tool. It excels in chatbots, content…

Computation and Language · Computer Science 2025-05-28 Walid Hariri

Accurate task planning is critical for controlling autonomous systems, such as robots, drones, and self-driving vehicles. Behavior Trees (BTs) are considered one of the most prominent control-policy-defining frameworks in task planning, due…

Robotics · Computer Science 2025-02-12 Azizjon Kobilov , Jianglin Lan

Bayesian adaptive clinical trials offer a flexible and efficient alternative to traditional fixed-design trials, but their implementation is often hindered by the complexity of Bayesian computations and the need for advanced statistical…

Applications · Statistics 2025-07-04 Krishna Padmanabhan , Danny Baker

Large Language Models (LLMs), including the LLaMA model, have exhibited their efficacy across various general-domain natural language processing (NLP) tasks. However, their performance in high-performance computing (HPC) domain tasks has…

Distributed, Parallel, and Cluster Computing · Computer Science 2023-11-23 Xianzhong Ding , Le Chen , Murali Emani , Chunhua Liao , Pei-Hung Lin , Tristan Vanderbruggen , Zhen Xie , Alberto E. Cerpa , Wan Du

Large language models have exhibited exceptional performance on various Natural Language Processing (NLP) tasks, leveraging techniques such as the pre-training, and instruction fine-tuning. Despite these advances, their effectiveness in…

Computation and Language · Computer Science 2023-06-19 Guangyu Wang , Guoxing Yang , Zongxin Du , Longjun Fan , Xiaohu Li
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