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Optical Coherence Tomography (OCT) has become one of the most used imaging modality in ophthalmology. It provides high-resolution, non-invasive visualization of retinal microarchitecture. The automated analysis of OCT images through…

Computer Vision and Pattern Recognition · Computer Science 2026-05-05 Hedi Tabia , Désiré Sidibé , Nawres Khlifa , Ahmed Tabia , Ines Rahmany , Noura Aboudi , Zainab Haddad , Hajer Khachnaoui , Hsouna Zgolli

We propose a novel method for non-rigid 3-D motion correction of orthogonally raster-scanned optical coherence tomography angiography volumes. This is the first approach that aligns predominantly axial structural features like retinal…

Optical coherence tomography (OCT) is a non-invasive volumetric imaging modality with high spatial and temporal resolution. For imaging larger tissue structures, OCT probes need to be moved to scan the respective area. For handheld…

Computer Vision and Pattern Recognition · Computer Science 2026-03-24 Suresh Guttikonda , Maximilian Neidhardt , Vidas Raudonis , Alexander Schlaefer

This paper presents a novel automated system that segments six sub-retinal layers from optical coherence tomography (OCT) image stacks of healthy patients and patients with diabetic macular edema (DME). First, each image in the OCT stack is…

Computer Vision and Pattern Recognition · Computer Science 2016-10-25 Sohini Roychowdhury , Dara D. Koozekanani , Michael Reinsbach , Keshab K. Parhi

Robotic automation has the potential to assist human surgeons in performing suturing tasks in microsurgery, and in order to do so a robot must be able to guide a needle with sub-millimeter precision through soft tissue. This paper presents…

Robotics · Computer Science 2020-03-16 Yuan Tian , Mark Draelos , Gao Tang , Ruobing Qian , Anthony Kuo , Joseph Izatt , Kris Hauser

Objective: Diabetic macular edema (DME) is the leading cause of severe visual impairment in patients with diabetes. Quantification of retinal fluid, particularly intraretinal fluid (IRF) and subretinal fluid (SRF), plays a critical role in…

Image and Video Processing · Electrical Eng. & Systems 2026-04-27 Zijun Lei , Zikang Xu , Liang Zhang , Ge Song , Hanyu Guo , Dan Cao , Yujia Zhou , Qianjin Feng

Subretinal injection is a delicate vitreoretinal procedure requiring precise needle placement within the subretinal space while avoiding perforation of the retinal pigment epithelium (RPE), a layer directly beneath the target with extremely…

Age-related macular degeneration (AMD) is a degenerative disorder affecting the macula, a key area of the retina for visual acuity. Nowadays, it is the most frequent cause of blindness in developed countries. Although some promising…

Image and Video Processing · Electrical Eng. & Systems 2022-12-06 José Morano , Álvaro S. Hervella , José Rouco , Jorge Novo , José I. Fernández-Vigo , Marcos Ortega

Optical Coherence Tomography Angiography (OCTA) is a non-invasive imaging technique that provides high-resolution cross-sectional images of the retina, which are useful for diagnosing and monitoring various retinal diseases. However, manual…

Image and Video Processing · Electrical Eng. & Systems 2023-11-07 Can Koz , Onat Dalmaz , Mertay Dayanc

Today, more than 12 million people over the age of 40 suffer from ocular diseases. Most commonly, older patients are susceptible to age related macular degeneration, an eye disease that causes blurring of the central vision due to the…

Image and Video Processing · Electrical Eng. & Systems 2022-05-03 Ananya Dua , Pham Hung Minh , Sajid Fahmid , Shikhar Gupta , Sophia Zheng , Vanessa Moyo , Yanran Elisa Xue

Optical coherence tomography (OCT) is a non-invasive, micrometer-scale imaging modality that has become a clinical standard in ophthalmology. By raster-scanning the retina, sequential cross-sectional image slices are acquired to generate…

Image and Video Processing · Electrical Eng. & Systems 2024-02-20 Stefan Ploner , Jungeun Won , Julia Schottenhamml , Jessica Girgis , Kenneth Lam , Nadia Waheed , James Fujimoto , Andreas Maier

Optical coherence tomography (OCT) as retina imaging technology is currently used by ophthalmologist as a non-invasive and non-contact method for diagnosis of agerelated degeneration (AMD) and diabetic macular edema (DME) diseases. Fluid…

Image and Video Processing · Electrical Eng. & Systems 2019-12-30 Elyas Rashno , Abdolreza Rashno , Sadegh Fadaei

In optical coherence tomography (OCT) volumes of retina, the sequential acquisition of the individual slices makes this modality prone to motion artifacts, misalignments between adjacent slices being the most noticeable. Any distortion in…

Machine Learning · Computer Science 2020-07-06 Yasmeen M. George , Suman Sedai , Bhavna J. Antony , Hiroshi Ishikawa , Gadi Wollstein , Joel S. Schuman , Rahil Garnavi

Ophthalmic images may contain identical-looking pathologies that can cause failure in automated techniques to distinguish different retinal degenerative diseases. Additionally, reliance on large annotated datasets and lack of knowledge…

Image and Video Processing · Electrical Eng. & Systems 2022-08-02 Sharif Amit Kamran , Khondker Fariha Hossain , Alireza Tavakkoli , Stewart Lee Zuckerbrod , Salah A. Baker

Optical coherence tomography (OCT) is one of the non-invasive and easy-to-acquire biomarkers (the thickness of the retinal layers, which is detectable within OCT scans) being investigated to diagnose Alzheimer's disease (AD). This work aims…

Image and Video Processing · Electrical Eng. & Systems 2022-06-14 Paria Jeihouni , Omid Dehzangi , Annahita Amireskandari , Ali Dabouei , Ali Rezai , Nasser M. Nasrabadi

Displacement estimation in optical coherence tomography (OCT) imaging is relevant for several potential applications, e.g. for optical coherence elastography (OCE) for corneal biomechanical characterization. Larger displacements may be…

Image and Video Processing · Electrical Eng. & Systems 2021-03-22 Hossein Khodadadi , Orcun Goksel , Sabine Kling

Objective: The advent of Electronic Medical Records (EMR) with large electronic imaging databases along with advances in deep neural networks with machine learning has provided a unique opportunity to achieve milestones in automated image…

Machine Learning · Statistics 2016-12-16 Cecilia S. Lee , Doug M. Baughman , Aaron Y. Lee

Age-related macular degeneration (AMD) may cause severe loss of vision or blindness particularly in elderly people. Exudative AMD is characterized by angiogenesis of blood vessels growing from underneath the macula, crossing the…

Biological Physics · Physics 2021-04-02 Rocío Vega , Manuel Carretero , Luis L. Bonilla

Cardiovascular diseases (CVD) are the leading cause of death globally. Non-invasive, cost-effective imaging techniques play a crucial role in early detection and prevention of CVD. Optical coherence tomography (OCT) has gained recognition…

Image and Video Processing · Electrical Eng. & Systems 2025-01-08 Cynthia Maldonado-Garcia , Rodrigo Bonazzola , Enzo Ferrante , Thomas H Julian , Panagiotis I Sergouniotis , Nishant Ravikumara , Alejandro F Frangi

Routine clinical imaging of the retina using optical coherence tomography (OCT) is performed with large slice spacing, resulting in highly anisotropic images and a sparsely scanned retina. Most learning-based methods circumvent the problems…

Computer Vision and Pattern Recognition · Computer Science 2026-03-13 Bennet Kahrs , Julia Andresen , Fenja Falta , Monty Santarossa , Heinz Handels , Timo Kepp