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Modern PET systems reach a spatial resolution of 3-10 mm. A disadvantage of this technique is the diffusion of the positron before its decay with a typical range of ca. 1 mm (depending on its energy). This motion and Compton scattering of…

Instrumentation and Detectors · Physics 2012-02-03 C. Lang , D. Habs , P. G. Thirolf , A. Zoglauer

We propose a fast beam orientation selection method, based on deep neural networks (DNN), capable of developing a plan comparable to those by the state-of-the-art column generation method. The novelty of Our model lies in its supervised…

Medical Physics · Physics 2019-12-23 Azar Sadeghnejad Barkousaraie , Olalekan Ogunmolu , Steve Jiang , Dan Nguyen

The rapid advancements in artificial intelligence (AI) have revolutionized smart healthcare, driving innovations in wearable technologies, continuous monitoring devices, and intelligent diagnostic systems. However, security, explainability,…

Machine Learning · Computer Science 2024-10-02 Prasenjit Maji , Amit Kumar Mondal , Hemanta Kumar Mondal , Saraju P. Mohanty

Spatial entanglement is a key resource in quantum technologies, enabling applications in quantum communication, imaging, and computation. However, propagation through complex media distorts spatial correlations, posing a challenge for…

Quantum Physics · Physics 2025-04-29 Kiran Bajar , Ronen Shekel , Vikas S. Bhat , Rounak Chatterjee , Yaron Bromberg , Sushil Mujumdar

Uncertainties in the proton range in tissue during proton therapy limit the precision in treatment delivery. These uncertainties result in expanded treatment margins, thereby increasing radiation dose to healthy tissue. Real-time range…

Medical Physics · Physics 2018-10-17 Kristian Smeland Ytre-Hauge , Kyrre Skjerdal , John Mattingly , Ilker Meric

In this study, we introduce a Compton SPECT system for whole-body imaging of Actinium-225 (225Ac), one of the trending radionuclides for targeted alpha therapy (TAT). The Compton SPECT system enables multi-energy gamma photon detection with…

Medical Physics · Physics 2025-06-23 Yuemeng Feng , Arkadiusz Sitek , Shadi Abdar Esfahani , Hamid Sabet

We have developed a compact Compton gamma-ray imager with a large field of view and a low channel-count that is capable of quickly localizing gamma-ray sources in the few hundred keV - several MeV range. The two detector planes (scatter and…

Instrumentation and Detectors · Physics 2015-06-18 A. M. L. MacLeod , P. J. Boyle , D. S. Hanna , P. R. B. Saull , L. E. Sinclair , H. C. J. Seywerd

The Computed Tomography (CT) for diagnosis of lesions in human internal organs is one of the most fundamental topics in medical imaging. Low-dose CT, which offers reduced radiation exposure, is preferred over standard-dose CT, and therefore…

Image and Video Processing · Electrical Eng. & Systems 2023-09-26 Wenjie Liu

Breast cancer is a significant cause of death from cancer in women globally, highlighting the need for improved diagnostic imaging to enhance patient outcomes. Accurate tumour identification is essential for diagnosis, treatment, and…

Image and Video Processing · Electrical Eng. & Systems 2024-05-15 Chi-en Amy Tai , Alexander Wong

Objective: Real-time adaptive proton range verification systems based on produced neutrons require accurate information on their non-isotropic momentum distributions within short times, for which Monte Carlo (MC) methods are too…

Skin cancer is a highly dangerous type of cancer that requires an accurate diagnosis from experienced physicians. To help physicians diagnose skin cancer more efficiently, a computer-aided diagnosis (CAD) system can be very helpful. In this…

Image and Video Processing · Electrical Eng. & Systems 2024-06-24 Ayush Roy , Sujan Sarkar , Sohom Ghosal , Dmitrii Kaplun , Asya Lyanova , Ram Sarkar

This work introduces a calibration framework for material parameter identification in isotropic hyperelastic constitutive models. The framework synergizes the Virtual Fields Method (VFM) to define an objective function with a Genetic…

Computational Physics · Physics 2025-10-10 Zicheng Yan , Jialiang Tao , Christian Franck , David L. Henann

Motivation: A pan-genome graph represents a collection of genomes and encodes sequence variations between them. It is a powerful data structure for studying multiple similar genomes. Sequence-to-graph alignment is an essential step for the…

Genomics · Quantitative Biology 2022-06-29 Haowen Zhang , Shiqi Wu , Srinivas Aluru , Heng Li

Purpose: To demonstrate a proton imaging system based on well-established fast scintillator technology to achieve high performance with low cost and complexity, with the potential of a straightforward translation into clinical use. Methods:…

Contours are used in radiotherapy treatment planning to identify regions to be irradiated with high dose and regions to be spared. Therefore, any contouring uncertainty influences the whole treatment. Even though this is the biggest…

Medical Physics · Physics 2022-04-22 Eliana Vásquez Osorio , Jane Shortall , Jennifer Robbins , Marcel van Herk

Genetic algorithms have played an important role in engineering optimization. Traditional GAs treat each gene separately. However, biophysical studies of gene regulatory networks revealed direct associations between different genes. It…

Neural and Evolutionary Computing · Computer Science 2024-05-01 Zhaoning Shi , Meng Xiang , Zhaoyang Hai , Xiabi Liu , Yan Pei

Proton beam therapy can potentially offer improved treatment for cancers of the head and neck and in paediatric patients. There has been a sharp uptake of proton beam therapy in recent years as improved delivery techniques and patient…

Background: Proton arc therapy is an emerging radiation therapy technique where either the gantry or the patient continuously rotates during the irradiation treatment. One of the perceived advantages of proton arc therapy is the reduced…

Medical Physics · Physics 2023-10-20 Viktor Wase , Otte Marthin , Albin Fredriksson , Anton Finnson

Study of high energy cosmic events in the MeV range requires detector with high efficiency and energy resolution to be constructed. The present setup consisting of scintillator crystals CeBr3 with different thickness, each coupled with 12 x…

Instrumentation and Detectors · Physics 2025-12-10 Veronika Asova , Galin Bistrev , Simeon Ivanov

Breast cancer is a significant public health concern and early detection is critical for triaging high risk patients. Sequential screening mammograms can provide important spatiotemporal information about changes in breast tissue over time.…

Image and Video Processing · Electrical Eng. & Systems 2023-06-05 Hong Hui Yeoh , Andrea Liew , Raphaël Phan , Fredrik Strand , Kartini Rahmat , Tuong Linh Nguyen , John L. Hopper , Maxine Tan