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We present a full-scale clinical prototype system for in vivo range verification of proton pencil-beams using the prompt gamma-ray spectroscopy method. The detection system consists of eight LaBr3 scintillators and a tungsten collimator,…

Purpose: The purpose of this work was to provide a flexible platform for FLASH research with protons by adapting a former clinical pencil beam scanning gantry to irradiations with ultrahigh dose rates. Methods: PSI Gantry 1 treated patients…

Imaging of nuclear gamma-ray lines in the 1-10 MeV range is far from being established in both medical and physical applications. In proton therapy, 4.4 MeV gamma rays are emitted from the excited nucleus of either 12^C^* or 11^B^* and are…

We report on an hybrid in-beam PET and prompt-gamma Compton imaging system aimed at quasi real-time ion-range verification in proton-therapy treatments. Proof-of-concept experiments were carried out at the radiobiology beam line of the CNA…

Around half of all cancer patients, world-wide, will receive some form of radiotherapy (RT) as part of their treatment. And yet, despite the rapid advance of high-throughput screening to identify successful chemotherapy drug candidates,…

Gravitational-wave detection strategies are based on a signal analysis technique known as matched filtering. Despite the success of matched filtering, due to its computational cost, there has been recent interest in developing deep…

In this work, we report on the advantageous aspects of the i-TED Compton imager for proton-range monitoring, based on the results of the first Monte Carlo study of its applicability to this field. i-TED is an array of Compton cameras, that…

We demonstrate training of a Generative Adversarial Network (GAN) for prediction of optical property maps (scattering and absorption) using spatial frequency domain imaging (SFDI) image data sets generated synthetically with free…

In the context of range monitoring for particle therapy, this study presents the first experimental results obtained with the TIARA detector using carbon-ion beams at the CNAO clinical center in Pavia, Italy. TIARA is based on the Prompt…

Delineation of tumors and organs-at-risk permits detecting and correcting changes in the patients' anatomy throughout the treatment, making it a core step of adaptive proton therapy (APT). Although AI-based auto-contouring technologies have…

Background: In MR-guided proton therapy planning, aligning MR and CT images is key for MR-based CT synthesis, especially in mobile regions like the head-and-neck. Misalignments here can lead to less accurate synthetic CT (sCT) images,…

The accuracy of hadrontherapy treatment is currently limited by ion-range uncertainties. In order to fully exploit the potential of this technique, we propose the development of a novel system for online control of particle therapy, based…

For optical coherence tomography angiography (OCTA) images, a limited scanning rate leads to a trade-off between field-of-view (FOV) and imaging resolution. Although larger FOV images may reveal more parafoveal vascular lesions, their…

In the context of particle therapy monitoring, we are developing a gamma-ray detector to determine the ion range in vivo from the measurement of particle time-of-flight. For this application, a beam monitor capable to tag in time the…

Verification of patient specific proton stopping powers obtained in the patient treatment position can be used to reduce the distal margins needed in particle beam planning. Proton radiography can be used as a pre-treatment instrument to…

Cognitive radio (CR) is to detect the presence of primary users (PUs) reliably in order to reduce the interference to licensed communications. Genetic algorithms (GAs) are well suited for CR optimization problems to increase efficiency of…

Since the discovery of nuclear gamma-rays, its imaging has been limited to pseudo imaging, such as Compton Camera (CC) and coded mask. Pseudo imaging does not keep physical information (intensity, or brightness in Optics) along a ray, and…

A Compton camera is the most promising approach for gamma-ray detection in the energy region from several hundred keV to MeV, especially for application in high energy astrophysics. In order to obtain good angular resolution, semiconductor…

Purpose: The FLASH effect, which reduces the radiosensitivity of healthy tissue while maintaining tumor control at high dose rates, has shown potential for improving radiation therapy. Conformal FLASH proton therapy involves advanced…

Accurate attenuation and scatter corrections are crucial in positron emission tomography (PET) imaging for accurate visual interpretation and quantitative analysis. Traditional methods relying on computed tomography (CT) or magnetic…