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Large language models (LLMs) have demonstrated remarkable capabilities in natural language understanding and generation across various domains, including medicine. We present a comprehensive evaluation of GPT-4, a state-of-the-art LLM, on…

Computation and Language · Computer Science 2023-04-13 Harsha Nori , Nicholas King , Scott Mayer McKinney , Dean Carignan , Eric Horvitz

Large language models (LLMs) have shown considerable promise in clinical natural language processing, yet few domain-specific datasets exist to rigorously evaluate their performance on radiology tasks. In this work, we introduce an…

Computation and Language · Computer Science 2025-11-18 Namu Park , Giridhar Kaushik Ramachandran , Kevin Lybarger , Fei Xia , Ozlem Uzuner , Meliha Yetisgen , Martin Gunn

Query optimization is essential for efficient SQL query execution in DBMS, and remains attractive over time due to the growth of data volumes and advances in hardware. Existing traditional optimizers struggle with the cumbersome hand-tuning…

Databases · Computer Science 2025-07-08 Suchen Liu , Jun Gao , Yinjun Han , Yang Lin

The rapid advancement of Large Language Models (LLMs) in the realm of mathematical reasoning necessitates comprehensive evaluations to gauge progress and inspire future directions. Existing assessments predominantly focus on problem-solving…

Computation and Language · Computer Science 2024-06-05 Xiaoyuan Li , Wenjie Wang , Moxin Li , Junrong Guo , Yang Zhang , Fuli Feng

Cancer clinical trials often face challenges in recruitment and engagement due to a lack of participant-facing informational and educational resources. This study investigated the potential of Large Language Models (LLMs), specifically…

Large language models (LLMs) like GPT-4 show potential for scaling motivational interviewing (MI) in addiction care, but require systematic evaluation of therapeutic capabilities. We present a computational framework assessing…

Computation and Language · Computer Science 2025-05-26 Yinghui Huang , Yuxuan Jiang , Hui Liu , Yixin Cai , Weiqing Li , Xiangen Hu

Advances in large language models (LLMs) have empowered a variety of applications. However, there is still a significant gap in research when it comes to understanding and enhancing the capabilities of LLMs in the field of mental health. In…

Computation and Language · Computer Science 2024-01-30 Xuhai Xu , Bingsheng Yao , Yuanzhe Dong , Saadia Gabriel , Hong Yu , James Hendler , Marzyeh Ghassemi , Anind K. Dey , Dakuo Wang

Purpose: To assess the alignment of GPT-4-based evaluation to human clinician experts, for the evaluation of responses to ophthalmology-related patient queries generated by fine-tuned LLM chatbots. Methods: 400 ophthalmology questions and…

Artificial Intelligence · Computer Science 2024-02-16 Ting Fang Tan , Kabilan Elangovan , Liyuan Jin , Yao Jie , Li Yong , Joshua Lim , Stanley Poh , Wei Yan Ng , Daniel Lim , Yuhe Ke , Nan Liu , Daniel Shu Wei Ting

Lab results are often confusing and hard to understand. Large language models (LLMs) such as ChatGPT have opened a promising avenue for patients to get their questions answered. We aim to assess the feasibility of using LLMs to generate…

Computation and Language · Computer Science 2024-04-23 Zhe He , Balu Bhasuran , Qiao Jin , Shubo Tian , Karim Hanna , Cindy Shavor , Lisbeth Garcia Arguello , Patrick Murray , Zhiyong Lu

There is a growing literature on reasoning by large language models (LLMs), but the discussion on the uncertainty in their responses is still lacking. Our aim is to assess the extent of confidence that LLMs have in their answers and how it…

Computation and Language · Computer Science 2024-12-23 Yudi Pawitan , Chris Holmes

Matching cancer patients to clinical trials is essential for advancing treatment and patient care. However, the inconsistent format of medical free text documents and complex trial eligibility criteria make this process extremely…

Large Language Models (LLMs) have revolutionized the field of Natural Language Processing thanks to their ability to reuse knowledge acquired on massive text corpora on a wide variety of downstream tasks, with minimal (if any) tuning steps.…

Computation and Language · Computer Science 2024-07-12 Flavio Petruzzellis , Alberto Testolin , Alessandro Sperduti

Previous learning-based vulnerability detection methods relied on either medium-sized pre-trained models or smaller neural networks from scratch. Recent advancements in Large Pre-Trained Language Models (LLMs) have showcased remarkable…

Software Engineering · Computer Science 2024-01-30 Xin Zhou , Ting Zhang , David Lo

Prompt optimization algorithms for Large Language Models (LLMs) excel in multi-step reasoning but still lack effective uncertainty estimation. This paper introduces a benchmark dataset to evaluate uncertainty metrics, focusing on Answer,…

Machine Learning · Computer Science 2024-12-30 Pei-Fu Guo , Yun-Da Tsai , Shou-De Lin

Measuring the generalization ability of Large Language Models (LLMs) is challenging due to data contamination. As models grow and computation becomes cheaper, ensuring tasks and test cases are unseen during training phases will become…

Computation and Language · Computer Science 2025-07-09 Sougata Saha , Monojit Choudhury

Recent investigations show that large language models (LLMs), specifically GPT-4, not only have remarkable capabilities in common Natural Language Processing (NLP) tasks but also exhibit human-level performance on various professional and…

Computation and Language · Computer Science 2023-06-05 Zhuo Wang , Rongzhen Li , Bowen Dong , Jie Wang , Xiuxing Li , Ning Liu , Chenhui Mao , Wei Zhang , Liling Dong , Jing Gao , Jianyong Wang

As large language models (LLMs) advance, their role in higher education, particularly in free-response problem-solving, requires careful examination. This study assesses the performance of GPT-4o and o1-preview under realistic educational…

Computers and Society · Computer Science 2025-05-21 Ming Ding , Rasmus Kyng , Federico Solda , Weixuan Yuan

Large Language Models (LLMs) are capable of reproducing human-like inferences, including inferences about emotions and mental states, from text. Whether this capability extends beyond text to other modalities remains unclear. Humans possess…

Specialized clinical AI assistants are rapidly entering medical practice, often framed as safer or more reliable than general-purpose large language models (LLMs). Yet, unlike frontier models, these clinical tools are rarely subjected to…

Computation and Language · Computer Science 2025-12-02 Krithik Vishwanath , Mrigayu Ghosh , Anton Alyakin , Daniel Alexander Alber , Yindalon Aphinyanaphongs , Eric Karl Oermann

Background: The potential of large language models (LLMs) to automate and support pharmacoepidemiologic study design is an emerging area of interest, yet their reliability remains insufficiently characterized. General-purpose LLMs often…

Computation and Language · Computer Science 2026-04-21 Xinyao Zhang , Nicole Sonne Heckmann , Manuela Del Castillo Suero , Francesco Paolo Speca , Maurizio Sessa