Related papers: Synthetic frequency-controlled gene circuits unloc…
This paper studies the problem of signal tracking and disturbance rejection for sampled-data control systems, where the pertinent signals can reside beyond the so-called Nyquist frequency. In light of the sampling theorem, it is generally…
It often is emphasized that gene expression is noisy. A seemingly contradictory view is that control mechanisms have been optimized to squeeze as much information as possible out of a limited number of molecules. Here we revisit these…
Synthetic molecular communication (SMC) is a key enabler for future healthcare systems in which Internet of Bio-Nano-Things (IoBNT) devices facilitate the continuous monitoring of a patient's biochemical signals. To close the loop between…
In this paper we study how to shape temporal pulses to switch a bistable system between its stable steady states. Our motivation for pulse-based control comes from applications in synthetic biology, where it is generally difficult to…
Frequency synthesis (FS) is a technique vital for all kinds of radio frequency (RF) communications, such as: mobile phones, Bluetooth, Wi-Fi, radio, TV and satellite, and in other equipment requiring periodic signals of stable and…
In order to prevent the potential frequency instability due to the high Power Electronics (PE) penetration under an unintentional islanding event, this paper presents a novel microgrid scheduling model which explicitly models the system…
One of the challenges in Synthetic Biology is to design circuits with increasing levels of complexity. While circuits in Biology are complex and subject to natural tradeoffs, most synthetic circuits are simple in terms of the number of…
Biological systems are driven by intricate interactions among the complex array of molecules that comprise the cell. Many methods have been developed to reconstruct network models of those interactions. These methods often draw on large…
Genetic circuits need a cellular environment to operate in, which naturally couples the circuit function with the overall functionality of gene regulatory network. To execute their functions all gene circuits draw resources in the form of…
We present a model of the evolution of control systems in a genome under environmental constraints. The model conceptually follows the Jacob and Monod model of gene control. Genes contain control elements which respond to the internal state…
Understanding how gene regulatory networks (GRNs) give rise to stable and dynamic cellular states remains a central challenge in theoretical biology, particularly when slow epigenetic feedback reshapes the underlying regulatory landscape.…
We introduce general results on well-posedness and output regulation of regular linear systems with nonautonomous controllers. We present a generalization of the internal model principle for time-dependent controllers with asymptotically…
Building circuits and studying their behavior in cells is a major goal of systems and synthetic biology. Synthetic biology enables the precise control of cellular states for systems studies, the discovery of novel parts, control strategies,…
Cells control fluid flows with a spatial and temporal precision that far exceeds the capabilities of current microfluidic technologies. Cells achieve this superior spatio-temporal control by harnessing dynamic networks of cytoskeleton and…
Simulating wave propagation on discrete grid in time domain requires the description of both the parameters of the media and the values of the wave field at two different time steps within the simulated domain. For most practical cases this…
Morphogenesis, the establishment and repair of emergent complex anatomy by groups of cells, is a fascinating and biomedically-relevant problem. One of its most fascinating aspects is that a developing embryo can reliably recover from…
The energy system is rapidly changing to accommodate the increasing number of renewable generators and the general transition towards a more sustainable future. Simultaneously, business models and market designs evolve, affecting power-grid…
Network reconfiguration (NR) has recently received significant attention due to its potential to improve grid resilience by realizing self-healing microgrids (MGs). This paper proposes a new strategy for the real-time frequency regulation…
Characterization of pluripotent states, in which cells can both self-renew and differentiate, and the irreversible loss of pluripotency are important research areas in developmental biology. In particular, an understanding of these…
This paper proposes a new strategy for optimal grid frequency regulation (FR) in an interconnected power system where regional ac grids and an offshore wind farm are linked via a multi-terminal high voltage direct-current (MTDC) network. In…