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The emergence of digital pathology has opened new horizons for histopathology and cytology. Artificial-intelligence algorithms are able to operate on digitized slides to assist pathologists with diagnostic tasks. Whereas machine learning…

The integration of multi-modal data, such as pathological images and genomic data, is essential for understanding cancer heterogeneity and complexity for personalized treatments, as well as for enhancing survival predictions. Despite the…

Quantitative Methods · Quantitative Biology 2023-01-09 Lin Qiu , Aminollah Khormali , Kai Liu

Artificial intelligence has made significant strides in medical visual question answering (Med-VQA), yet prevalent studies often interpret images holistically, overlooking the visual regions of interest that may contain crucial information,…

Computer Vision and Pattern Recognition · Computer Science 2025-03-11 Xupeng Chen , Zhixin Lai , Kangrui Ruan , Shichu Chen , Jiaxiang Liu , Zuozhu Liu

In this work, we introduce RadImageNet-VQA, a large-scale dataset designed to advance radiologic visual question answering (VQA) on CT and MRI exams. Existing medical VQA datasets are limited in scale, dominated by X-ray imaging or…

Computer Vision and Pattern Recognition · Computer Science 2026-03-31 Léo Butsanets , Charles Corbière , Julien Khlaut , Pierre Manceron , Corentin Dancette

Retrieval-Augmented Generation (RAG) has proven effective in integrating external knowledge into large language models (LLMs) for solving question-answer (QA) tasks. The state-of-the-art RAG approaches often use the graph data as the…

Information Retrieval · Computer Science 2026-05-12 Shu Wang , Yixiang Fang , Yingli Zhou , Xilin Liu , Yuchi Ma

In healthcare, it is essential to explain the decision-making process of machine learning models to establish the trustworthiness of clinicians. This paper introduces BI-RADS-Net, a novel explainable deep learning approach for cancer…

Computer Vision and Pattern Recognition · Computer Science 2021-10-11 Boyu Zhang , Aleksandar Vakanski , Min Xian

Radiology reporting is a crucial part of the communication between radiologists and other medical professionals, but it can be time-consuming and error-prone. One approach to alleviate this is structured reporting, which saves time and…

Computer Vision and Pattern Recognition · Computer Science 2023-09-08 Chantal Pellegrini , Matthias Keicher , Ege Özsoy , Nassir Navab

Breast cancer survival prediction in computational pathology presents a remarkable challenge due to tumor heterogeneity. For instance, different regions of the same tumor in the pathology image can show distinct morphological and molecular…

Image and Video Processing · Electrical Eng. & Systems 2025-03-25 Yang Luo , Shiru Wang , Jun Liu , Jiaxuan Xiao , Rundong Xue , Zeyu Zhang , Hao Zhang , Yu Lu , Yang Zhao , Yutong Xie

Endoscopy is widely used to diagnose gastric cancer and has a high diagnostic performance, but it must be performed by a physician, which limits the number of people who can be diagnosed. In contrast, gastric X-rays can be taken by…

Image and Video Processing · Electrical Eng. & Systems 2025-02-06 Hideaki Okamoto , Quan Huu Cap , Takakiyo Nomura , Kazuhito Nabeshima , Jun Hashimoto , Hitoshi Iyatomi

Integrating histopathology with spatial transcriptomics (ST) provides a powerful opportunity to link tissue morphology with molecular function. Yet most existing multimodal approaches rely on a small set of highly variable genes, which…

Computer Vision and Pattern Recognition · Computer Science 2025-10-07 Sejuti Majumder , Saarthak Kapse , Moinak Bhattacharya , Xuan Xu , Alisa Yurovsky , Prateek Prasanna

Digital pathology is not only one of the most promising fields of diagnostic medicine, but at the same time a hot topic for fundamental research. Digital pathology is not just the transfer of histopathological slides into digital…

Artificial Intelligence · Computer Science 2017-12-20 Andreas Holzinger , Bernd Malle , Peter Kieseberg , Peter M. Roth , Heimo Müller , Robert Reihs , Kurt Zatloukal

Standard Retrieval-Augmented Generation (RAG) relies on chunk-based retrieval, whereas GraphRAG advances this approach by graph-based knowledge representation. However, existing graph-based RAG approaches are constrained by binary…

Artificial Intelligence · Computer Science 2025-10-22 Haoran Luo , Haihong E , Guanting Chen , Yandan Zheng , Xiaobao Wu , Yikai Guo , Qika Lin , Yu Feng , Zemin Kuang , Meina Song , Yifan Zhu , Luu Anh Tuan

Motivation: Digitization of pathology laboratories through digital slide scanners and advances in deep learning approaches for objective histological assessment have resulted in rapid progress in the field of computational pathology (CPath)…

Machine Learning · Computer Science 2022-01-31 Alex Foote , Amina Asif , Nasir Rajpoot , Fayyaz Minhas

Large Language Models (LLMs) have significantly advanced medical question-answering by leveraging extensive clinical data and medical literature. However, the rapid evolution of medical knowledge and the labor-intensive process of manually…

Computation and Language · Computer Science 2025-07-01 Mohammad Reza Rezaei , Reza Saadati Fard , Jayson L. Parker , Rahul G. Krishnan , Milad Lankarany

Recent graph-based RAG approaches leverage knowledge graphs by extracting entities from a query to fetch their associated relationships and metadata. However, relying solely on entity extraction often results in the misinterpretation or…

Computation and Language · Computer Science 2026-01-22 Ningyuan Li , Junrui Liu , Yi Shan , Minghui Huang , Ziren Gong , Tong Li

Retrieval Augmented Generation (RAG) has become the standard approach for equipping Large Language Models (LLMs) with up-to-date knowledge. However, standard RAG, relying on independent passage retrieval, often fails to capture the…

Computation and Language · Computer Science 2025-11-20 Jingjin Wang , Jiawei Han

Retrieval-Augmented Generation (RAG) improves large language models by retrieving external knowledge, often truncated into smaller chunks due to the input context window, which leads to information loss, resulting in response hallucinations…

Computation and Language · Computer Science 2025-11-18 Jie Zhang , Bo Tang , Wanzi Shao , Wenqiang Wei , Jihao Zhao , Jianqing Zhu , Zhiyu li , Wen Xi , Zehao Lin , Feiyu Xiong , Yanchao Tan

Histopathology refers to the examination by a pathologist of biopsy samples. Histopathology images are captured by a microscope to locate, examine, and classify many diseases, such as different cancer types. They provide a detailed view of…

Image and Video Processing · Electrical Eng. & Systems 2020-11-12 Naira Elazab , Hassan Soliman , Shaker El-Sappagh , S. M. Riazul Islam , Mohammed Elmogy

Existing multimodal Retrieval-Augmented Generation (RAG) methods for visually rich documents (VRD) are often biased towards retrieving salient knowledge(e.g., prominent text and visual elements), while largely neglecting the critical…

Information Retrieval · Computer Science 2025-11-26 Anyang Tong , Xiang Niu , ZhiPing Liu , Chang Tian , Yanyan Wei , Zenglin Shi , Meng Wang

Retrieving visual and textual information from medical literature and hospital records can enhance diagnostic accuracy for clinical image interpretation. However, multimodal retrieval-augmented diagnosis is highly challenging. We explore a…

Computer Vision and Pattern Recognition · Computer Science 2026-04-21 Nir Mazor , Tom Hope
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