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Related papers: ST-Align: A Multimodal Foundation Model for Image-…

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Video-language alignment is a crucial multi-modal task that benefits various downstream applications, e.g., video-text retrieval and video question answering. Existing methods either utilize multi-modal information in video-text pairs or…

Computer Vision and Pattern Recognition · Computer Science 2024-07-25 Shi-Xue Zhang , Hongfa Wang , Xiaobin Zhu , Weibo Gu , Tianjin Zhang , Chun Yang , Wei Liu , Xu-Cheng Yin

Foundation models (FMs) are transforming computational pathology by offering new ways to analyze histopathology images. However, FMs typically require weeks of training on large databases, making their creation a resource-intensive process.…

Image and Video Processing · Electrical Eng. & Systems 2026-01-27 Till Nicke , Daniela Schacherer , Jan Raphael Schäfer , Natalia Artysh , Antje Prasse , André Homeyer , Andrea Schenk , Henning Höfener , Johannes Lotz

3D medical vision-language (VL) pretraining has shown potential in radiology by leveraging large-scale multimodal datasets with CT-report pairs. However, existing methods primarily rely on a global VL alignment directly adapted from 2D…

Computer Vision and Pattern Recognition · Computer Science 2025-12-03 Jingyang Lin , Yingda Xia , Jianpeng Zhang , Ke Yan , Kai Cao , Le Lu , Jiebo Luo , Ling Zhang

Multimodal models have demonstrated powerful capabilities in complex tasks requiring multimodal alignment, including zero-shot classification and cross-modal retrieval. However, existing models typically rely on millions of paired…

Computer Vision and Pattern Recognition · Computer Science 2025-10-23 Fabian Gröger , Shuo Wen , Huyen Le , Maria Brbić

Cross-modal alignment aims to map heterogeneous modalities into a shared latent space, as exemplified by models like CLIP, which benefit from large-scale image-text pretraining for strong recognition capabilities. However, when operating in…

Computer Vision and Pattern Recognition · Computer Science 2025-10-27 Jiaxiang Liu , Yuan Wang , Jiawei Du , Joey Tianyi Zhou , Mingkun Xu , Zuozhu Liu

Spatial transcriptomics offers spatially resolved gene expression profiling within tissue sections, but its cost and limited throughput hinder large-scale deployment. To extend this capability to routine practice, recent computational…

Machine Learning · Computer Science 2026-05-07 Keunho Byeon , Jin Tae Kwak

The advancement of Spatial Transcriptomics (ST) has facilitated the spatially-aware profiling of gene expressions based on histopathology images. Although ST data offers valuable insights into the micro-environment of tumors, its…

Computer Vision and Pattern Recognition · Computer Science 2024-12-23 Hongyi Wang , Xiuju Du , Jing Liu , Shuyi Ouyang , Yen-Wei Chen , Lanfen Lin

Triggered by the success of transformers in various visual tasks, the spatial self-attention mechanism has recently attracted more and more attention in the computer vision community. However, we empirically found that a typical vision…

Computer Vision and Pattern Recognition · Computer Science 2022-11-28 Jiayin Sun , Hong Wang , Qiulei Dong

Spatial transcriptomics (ST) provides crucial insights into tissue micro-environments, but is limited to its high cost and complexity. As an alternative, predicting gene expression from pathology whole slide images (WSI) is gaining…

Computer Vision and Pattern Recognition · Computer Science 2025-07-01 Mingcheng Qu , Yuncong Wu , Donglin Di , Yue Gao , Tonghua Su , Yang Song , Lei Fan

The integration of spatial multi-omics data from single tissues is crucial for advancing biological research. However, a significant data imbalance impedes progress: while spatial transcriptomics data is relatively abundant, spatial…

Artificial Intelligence · Computer Science 2026-02-06 Zhaorui Jiang , Yingfang Yuan , Lei Hu , Wei Pang

The rapid development of spatial transcriptomics (ST) technologies is revolutionizing our understanding of the spatial organization of biological tissues. Current ST methods, categorized into next-generation sequencing-based (seq-based) and…

Machine Learning · Computer Science 2024-07-19 Xiaoyu Li , Fangfang Zhu , Wenwen Min

Foundation models, large-scale, pre-trained deep-learning models adapted to a wide range of downstream tasks have gained significant interest lately in various deep-learning problems undergoing a paradigm shift with the rise of these…

Computer Vision and Pattern Recognition · Computer Science 2023-10-31 Bobby Azad , Reza Azad , Sania Eskandari , Afshin Bozorgpour , Amirhossein Kazerouni , Islem Rekik , Dorit Merhof

"Is it possible to predict expression levels of different genes at a given spatial location in the routine histology image of a tumor section by modeling its stain absorption characteristics?" In this work, we propose a "stain-aware"…

Image and Video Processing · Electrical Eng. & Systems 2021-08-27 Muhammad Dawood , Kim Branson , Nasir M. Rajpoot , Fayyaz ul Amir Afsar Minhas

Semi-supervised semantic segmentation in computational pathology remains challenging due to scarce pixel-level annotations and unreliable pseudo-label supervision. We propose UniSemAlign, a dual-modal semantic alignment framework that…

Computer Vision and Pattern Recognition · Computer Science 2026-04-13 Le-Van Thai , Tien Dat Nguyen , Hoai Nhan Pham , Lan Anh Dinh Thi , Duy-Dong Nguyen , Ngoc Lam Quang Bui

Foundation models in computational pathology promise to unlock the development of new clinical decision support systems and models for precision medicine. However, there is a mismatch between most clinical analysis, which is defined at the…

Spatial transcriptomics (ST) technologies have revolutionized the study of gene expression patterns in tissues by providing multimodality data in transcriptomic, spatial, and morphological, offering opportunities for understanding tissue…

Computational Engineering, Finance, and Science · Computer Science 2024-01-17 Zelin Zang , Liangyu Li , Yongjie Xu , Chenrui Duan , Kai Wang , Yang You , Yi Sun , Stan Z. Li

The prowess that makes few-shot learning desirable in medical image analysis is the efficient use of the support image data, which are labelled to classify or segment new classes, a task that otherwise requires substantially more training…

Vision-grounded medical report generation aims to produce clinically accurate descriptions of medical images, anchored in explicit visual evidence to improve interpretability and facilitate integration into clinical workflows. However,…

Computer Vision and Pattern Recognition · Computer Science 2025-10-01 Longzhen Yang , Zhangkai Ni , Ying Wen , Yihang Liu , Lianghua He , Heng Tao Shen

Multimodal learning, especially large-scale multimodal pre-training, has developed rapidly over the past few years and led to the greatest advances in artificial intelligence (AI). Despite its effectiveness, understanding the underlying…

Neural and Evolutionary Computing · Computer Science 2022-08-18 Haoyu Lu , Qiongyi Zhou , Nanyi Fei , Zhiwu Lu , Mingyu Ding , Jingyuan Wen , Changde Du , Xin Zhao , Hao Sun , Huiguang He , Ji-Rong Wen

Sleep staging is critical to assess sleep quality and diagnose disorders. Despite advancements in artificial intelligence enabling automated sleep staging, significant challenges remain: (1) Simultaneously extracting prominent temporal and…

Neurons and Cognition · Quantitative Biology 2025-09-26 Jingying Ma , Qika Lin , Ziyu Jia , Mengling Feng
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