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The proper functioning of multicellular organisms requires the robust establishment of precise proportions between distinct cell-types. This developmental differentiation process typically involves intracellular regulatory and stochastic…

Cell Behavior · Quantitative Biology 2016-06-22 Benjamin Pfeuty , Kunihiko Kaneko

From the formation of ice in small clusters of water molecules to the mass raids of army ant colonies, the emergent behavior of collectives depends critically on their size. At the same time, common wisdom holds that such behaviors are…

Populations and Evolution · Quantitative Biology 2025-10-08 Jacob Calvert , Andréa W. Richa , Dana Randall

Experimental observations of an almost symmetric electronic circuit show complicated sequences of bifurcations. These results are discussed in the light of a theory of imperfect global bifurcations. It is shown that much of the dynamics…

Chaotic Dynamics · Physics 2009-11-07 Paul Glendinning , Jan Abshagen , Tom Mullin

Two dynamical models that have been proposed to describe transitions between low and high confinement states (L-H transitions) in confined plasmas are analysed using singularity theory and stability theory. It is shown that the…

Mathematical Physics · Physics 2009-10-31 R. Ball , R. L. Dewar

We study a model describing $N$ identical bosonic atoms trapped in a double-well potential together with a single impurity atom, comparing and contrasting it throughout with the Dicke model. As the boson-impurity coupling strength is…

Quantum Gases · Physics 2019-11-26 Jesse Mumford , Jonas Larson , D. H. J. O'Dell

We present a quantitative semiclassical treatment of the effects of bifurcations on the spectral rigidity and the spectral form factor of a Hamiltonian quantum system defined by two coupled quartic oscillators, which on the classical level…

Chaotic Dynamics · Physics 2016-08-16 Marta Gutiérrez , Matthias Brack , Klaus Richter , Ayumu Sugita

Bifurcations can cause dynamical systems with slowly varying parameters to transition to far-away attractors. The terms ``critical transition'' or ``tipping point'' have been used to describe this situation. Critical transitions have been…

Dynamical Systems · Mathematics 2015-03-17 Christian Kuehn

Building Virtual Cells that can accurately simulate cellular responses to perturbations is a long-standing goal in systems biology. A fundamental challenge is that high-throughput single-cell sequencing is destructive: the same cell cannot…

Machine Learning · Computer Science 2026-02-24 Xinyu Yuan , Xixian Liu , Ya Shi Zhang , Zuobai Zhang , Hongyu Guo , Jian Tang

People are often divided into conformists and contrarians, the former tending to align to the majority opinion in their neighborhood and the latter tending to disagree with that majority. In practice, however, the contrarian tendency is…

Cellular Automata and Lattice Gases · Physics 2013-12-16 Franco Bagnoli , Raul Rechtman

During overflow metabolism, cells excrete glycolytic byproducts when growing under aerobic conditions in a seemingly wasteful fashion. While potentially advantageous for microbes with finite oxidative capacity, its role in higher organisms…

With the help of a mathematical model, the metabolic process of the Krebs cycle is studied. The autocatalytic processes resulting in both the formation of the self-organization in the Krebs cycle and the appearance of a cyclicity of its…

Molecular Networks · Quantitative Biology 2017-10-26 V. I. Grytsay , I. V. Musatenko

Cell polarity and movement are fundamental to many biological functions. Experimental and theoretically studies have indicated that interactions of certain proteins lead to the cell polarization which plays a key role in controlling the…

Dynamical Systems · Mathematics 2022-08-12 Shuang Liu , Li-Tien Cheng , Bo Li

Neural networks acquire structured representations at specific moments during training, yet identifying these transitions typically relies on retrospective, label-dependent metrics. We introduce a bifurcation theory of representation…

Machine Learning · Computer Science 2026-05-26 Fuming Yang

Intercellular exchange networks are essential for the adaptive capabilities of populations of cells. While diffusional exchanges have traditionally been difficult to map, recent advances in nanotechnology enable precise probing of exchange…

Statistical Mechanics · Physics 2024-12-13 Luís C. F. Latoski , Andrea De Martino , Daniele De Martino

We consider homogeneous coupled cell networks with asymmetric inputs. We obtain general results concerning codimension-one steady-state bifurcations for networks with any number of cells and any number of asymmetric inputs. These results…

Dynamical Systems · Mathematics 2024-06-05 Manuela Aguiar , Ana Dias , Pedro Soares

Cellular bioelectricity describes the biological phenomenon in which cells in living tissue generate and maintain patterns of voltage gradients induced by differing concentrations of charged ions. A growing body of research suggests that…

Distributed, Parallel, and Cluster Computing · Computer Science 2018-09-27 Seth Gilbert , James Maguire , Calvin Newport

On a two-dimensional circular domain, we analyze the formation of spatio-temporal patterns for a class of coupled bulk-surface reaction-diffusion models for which a passive diffusion process occurring in the interior bulk domain is linearly…

Pattern Formation and Solitons · Physics 2020-08-11 Frédéric Paquin-Lefebvre , Wayne Nagata , Michael J. Ward

We study the dynamics of a low-dimensional system of coupled model neurons as a step towards understanding the vastly complex network of neurons in the brain. We analyze the bifurcation structure of a system of two model neurons with…

Dynamical Systems · Mathematics 2019-03-27 Elizabeth N. Davison , Zahra Aminzare , Biswadip Dey , Naomi Ehrich Leonard

Phase separation, crucial for spatially segregating biomolecules in cells, is well-understood in the simple case of a few components with pairwise interactions. Yet, biological cells challenge the simple picture in at least two ways: First,…

Soft Condensed Matter · Physics 2024-03-12 Chengjie Luo , Yicheng Qiang , David Zwicker

Gap-junctional coupling is an important way of communication between neurons and other excitable cells. Strong electrical coupling synchronizes activity across cell ensembles. Surprisingly, in the presence of noise synchronous oscillations…

Adaptation and Self-Organizing Systems · Physics 2012-06-05 Georgi S. Medvedev , Svitlana Zhuravytska