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The diagnosis of primary liver cancers (PLCs) can be challenging, especially on biopsies and for combined hepatocellular-cholangiocarcinoma (cHCC-CCA). We automatically classified PLCs on routine-stained biopsies using a weakly supervised…

Development of machine learning (ML) workflows is a tedious process of iterative experimentation: developers repeatedly make changes to workflows until the desired accuracy is attained. We describe our vision for a "human-in-the-loop" ML…

Databases · Computer Science 2018-04-18 Doris Xin , Litian Ma , Jialin Liu , Stephen Macke , Shuchen Song , Aditya Parameswaran

Hand-crafted features extracted from dynamic contrast-enhanced magnetic resonance images (DCE-MRIs) have shown strong predictive abilities in characterization of breast lesions. However, heterogeneity across medical image datasets hinders…

Medical Physics · Physics 2017-01-17 Natalia Antropova , Benjamin Huynh , Maryellen Giger

Motivation: Tumor classification using Imaging Mass Spectrometry (IMS) data has a high potential for future applications in pathology. Due to the complexity and size of the data, automated feature extraction and classification steps are…

Machine Learning · Statistics 2018-06-28 Jens Behrmann , Christian Etmann , Tobias Boskamp , Rita Casadonte , Jörg Kriegsmann , Peter Maass

Image clustering is a very useful technique that is widely applied to various areas, including remote sensing. Recently, visual representations by self-supervised learning have greatly improved the performance of image clustering. To…

Computer Vision and Pattern Recognition · Computer Science 2022-09-27 Qinglin Li , Guoping Qiu

Current person re-identification (re-id) methods assume that (1) pre-labelled training data are available for every camera pair, (2) the gallery size for re-identification is moderate. Both assumptions scale poorly to real-world…

Computer Vision and Pattern Recognition · Computer Science 2018-05-08 Hanxiao Wang , Shaogang Gong , Xiatian Zhu , Tao Xiang

In this study, to address the current high earlydetection miss rate of colorectal cancer (CRC) polyps, we explore the potentials of utilizing transfer learning and machine learning (ML) classifiers to precisely and sensitively classify the…

Image and Video Processing · Electrical Eng. & Systems 2022-11-10 Nethra Venkatayogi , Ozdemir Can Kara , Jeff Bonyun , Naruhiko Ikoma , Farshid Alambeigi

Classification and clustering have been studied separately in machine learning and computer vision. Inspired by the recent success of deep learning models in solving various vision problems (e.g., object recognition, semantic segmentation)…

Machine Learning · Computer Science 2017-12-13 Ali Borji , Aysegul Dundar

The next generation of data-intensive surveys are bound to produce a vast amount of data, which can be dealt with using machine-learning methods to explore possible correlations within the multi-dimensional parameter space. We explore the…

Purpose Tumor-infiltrating lymphocytes (TILs) have significant prognostic values in cancers. However, very few automated, deep-learning-based TIL scoring algorithms have been developed for colorectal cancers (CRC). Methods We developed an…

Quantitative Methods · Quantitative Biology 2022-09-16 Anran Liu , Xingyu Li , Hongyi Wu , Bangwei Guo , Jitendra Jonnagaddala , Hong Zhang , Xu Steven Xu

Flow cytometry is a technique that measures multiple fluorescence and light scatter-associated parameters from individual cells as they flow a single file through an excitation light source. These cells are labeled with antibodies to detect…

Tumour-infiltrating lymphocytes (TILs) are considered as a valuable prognostic markers in both triple-negative and human epidermal growth factor receptor 2 (HER2) positive breast cancer. In this study, we introduce an innovative deep…

Image and Video Processing · Electrical Eng. & Systems 2023-11-22 Adam J Shephard , Mostafa Jahanifar , Ruoyu Wang , Muhammad Dawood , Simon Graham , Kastytis Sidlauskas , Syed Ali Khurram , Nasir M Rajpoot , Shan E Ahmed Raza

Accurate classification of blood cells plays a key role in improving automated blood analysis for both medical and veterinary applications. This work presents a two-stage deep clustering method for classifying blood cells from…

Quantitative Methods · Quantitative Biology 2025-09-25 Mihaela Macarie-Ancau , Adrian Groza

In this paper we discuss a new method for detecting leukemia in microscopic blood smear images using deep neural networks to diagnose leukemia early in blood. leukemia is considered one of the most dangerous mortality causes for a human…

Image and Video Processing · Electrical Eng. & Systems 2023-01-10 Abdelmageed Ahmed , Alaa Nagy , Ahmed Kamal , Daila Farghl

Multi-instance multi-label (MIML) learning is a challenging problem in many aspects. Such learning approaches might be useful for many medical diagnosis applications including breast cancer detection and classification. In this study subset…

Computer Vision and Pattern Recognition · Computer Science 2015-10-13 Baris Gecer , Ozge Yalcinkaya , Onur Tasar , Selim Aksoy

Quantification of lymphoid aggregates including tertiary lymphoid structures with germinal centers in histology images of cancer is a promising approach for developing prognostic and predictive tissue biomarkers. In this article, we provide…

Tissues and Organs · Quantitative Biology 2024-03-08 Karina Silina , Francesco Ciompi

An intrinsic problem of classifiers based on machine learning (ML) methods is that their learning time grows as the size and complexity of the training dataset increases. For this reason, it is important to have efficient computational…

Machine Learning · Computer Science 2013-04-16 Khadoudja Ghanem

We develop a novel algorithm, Predictive Hierarchical Clustering (PHC), for agglomerative hierarchical clustering of current procedural terminology (CPT) codes. Our predictive hierarchical clustering aims to cluster subgroups, not…

Methodology · Statistics 2017-08-03 Elizabeth C. Lorenzi , Stephanie L. Brown , Zhifei Sun , Katherine Heller

Whole-slide image classification represents a key challenge in computational pathology and medicine. Attention-based multiple instance learning (MIL) has emerged as an effective approach for this problem. However, the effect of attention…

Quantitative Methods · Quantitative Biology 2025-03-14 Rajiv Krishnakumar , Julien Baglio , Frederik F. Flöther , Christian Ruiz , Stefan Habringer , Nicole H. Romano

Algorithm selection is commonly used to predict the best solver from a portfolio per per-instance. In many real scenarios, instances arrive in a stream: new instances become available over time, while the number of class labels can also…

Machine Learning · Computer Science 2025-06-03 Mate Botond Nemeth , Emma Hart , Kevin Sim , Quentin Renau