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The native structures of proteins, except for notable exceptions of intrinsically disordered proteins, in general take their most stable conformation in the physiological condition to maintain their structural framework so that their…

Biomolecules · Quantitative Biology 2021-10-26 Lyman Monroe , Daisuke Kihara

Fast and accurate molecular force field (FF) parameterization is still an unsolved problem. Accurate FFs are not generally available for all molecules, like novel druglike molecules. While methods based on quantum mechanics (QM) exist to…

Chemical Physics · Physics 2019-08-06 Raimondas Galvelis , Stefan Doerr , Joao M. Damas , Matt J. Harvey , Gianni De Fabritiis

The requirement of high space-time resolution and brightness is a great challenge for imaging atomic motion and making molecular movies. Important breakthroughs in ultrabright tabletop laser, x-ray and electron sources have enabled the…

Atomic Physics · Physics 2022-02-10 Ming Zhang , Zhenning Guo , Xiaoyu Mi , Zheng Li , Yunquan Liu

Friction is a complicated phenomenon involving nonlinear dynamics at different length and time scales[1, 2]. The microscopic origin of friction is poorly understood, due in part to a lack of methods for measuring the force on a…

Mesoscale and Nanoscale Physics · Physics 2017-01-04 Per-Anders Thorén , Astrid S. de Wijn , Riccardo Borgani , Daniel Forchheimer , David B. Haviland

Non--Contact Atomic Force Microscopy with CO--functionalized metal tips (referred to as HR-AFM) provides access to the internal structure of individual molecules adsorbed on a surface with totally unprecedented resolution. Previous works…

Atomic force microscopy (AFM) is an analytical surface characterization tool which can reveal a sample's topography with high spatial resolution while simultaneously probing tip-sample interactions. Local measurement of chemical properties…

Applied Physics · Physics 2018-09-06 Omur E. Dagdeviren , Yoichi Miyahara , Aaron Mascaro , Peter Grutter

Precise manipulation of single molecules has already led to remarkable insights in physics, chemistry, biology and medicine. However, widespread adoption of single-molecule techniques has been impeded by equipment cost and the laborious…

Biological Physics · Physics 2015-05-14 Ken Halvorsen , Wesley P. Wong

Polar heavy-atom molecules have been well recognized as promising candidates for precision measurements and tests of fundamental physics. A much slower molecular beam to increase the interaction time should lead to a more sensitive…

Atomic Physics · Physics 2018-04-11 Yanning Yin , Supeng Xu , Meng Xia , Yong Xia , Jianping Yin

We present results of Niobium based SQUID magnetometers for which the weak-links are engineered by the local oxidation of thin films using an Atomic Force Microscope (AFM). Firstly, we show that this technique allows the creation of…

With recent advances in dynamic scanning probe microscopy techniques, it is now a routine to image the sub-molecular structure of molecules with atomically-engineered tips which are prepared via controlled modification of the tip…

Applied Physics · Physics 2019-03-06 Omur E. Dagdeviren

A low cost scheme to determine the frequency sweep nonlinearity using atomic saturated absorption spectroscopy is demonstrated. The frequency modulation rate is determined by directly measuring the interference fringe number and frequency…

Instrumentation and Detectors · Physics 2017-10-11 Ningfang Song , Xiangxiang Lu , Xiaobin Xu , Xiong Pan , Wei Li , Di Hu , Jixun Liu

High-speed optical imaging of dynamic neuronal activity is essential yet challenging in neuroscience. While calcium imaging has been firmly established as a workhorse technique for monitoring neuronal activity, its limited temporal…

Frequency-modulation atomic force microscopy provides an outstanding precision of the measurement of chemical bonding forces. However, as the cantilever oscillates with an amplitude A that is usually on the order of atomic dimensions or…

Materials Science · Physics 2021-08-13 Ferdinand Huber , Franz J. Giessibl

Near-field scanning optical microscopy has been an indispensable tool for designing, characterizing and understanding the functionalities of diverse nanoscale photonic devices. As the advances in fabrication technology have driven the…

Fast camera imaging is used to study ion acoustic waves propagating azimuthally in a magnetized plasma column. The high speed image sequences are analyzed using Proper Orthogonal Decomposition and 2D Fourier Transform, allowing to evaluate…

Plasma Physics · Physics 2023-02-01 Simon Vincent , Vincent Dolique , Nicolas Plihon

We resolve the real-time electric field of a femtosecond third-order nonlinear optical signal in the molecular frame. The electric field emitted by the induced third-order polarization from impulsively pre-aligned gas-phase molecules at…

We demonstrate quantitative force imaging of long-range magnetic forces simultaneously with near-surface van-der-Waals and contact-mechanics forces using intermodulation atomic force microscopy. Magnetic forces at the 200 pN level are…

Mesoscale and Nanoscale Physics · Physics 2014-07-16 Daniel Forchheimer , Daniel Platz , Erik A. Tholen , David B. Haviland

Atomic force microscopy (AFM) phase approach-curves have significant potential for nanoscale material characterization, however, the availability of robust datasets and automated analysis tools has been limited. In this paper, we introduce…

Atomistic modeling of thin-film processes provides an avenue not only for discovering key chemical mechanisms of the processes but also to extract quantitative metrics on the events and reactions taking place at the gas-surface interface.…

Materials Science · Physics 2025-05-05 S. Kondati Natarajan , J. Schneider , N. Pandey , J. Wellendorff , S. Smidstrup

We discuss the influence of external forces on the motion of the tip in dynamic atomic force microscopy (AFM). First, a compact solution for the steady-state problem is derived employing a Fourier approach. Founding on this solution, we…

Mesoscale and Nanoscale Physics · Physics 2019-01-29 Tino Wagner