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We present a deep learning strategy that enables, for the first time, contrast-agnostic semantic segmentation of completely unpreprocessed brain MRI scans, without requiring additional training or fine-tuning for new modalities. Classical…

Image and Video Processing · Electrical Eng. & Systems 2021-04-09 Benjamin Billot , Douglas Greve , Koen Van Leemput , Bruce Fischl , Juan Eugenio Iglesias , Adrian V. Dalca

Despite advances in data augmentation and transfer learning, convolutional neural networks (CNNs) difficultly generalise to unseen domains. When segmenting brain scans, CNNs are highly sensitive to changes in resolution and contrast: even…

Image and Video Processing · Electrical Eng. & Systems 2023-03-01 Benjamin Billot , Douglas N. Greve , Oula Puonti , Axel Thielscher , Koen Van Leemput , Bruce Fischl , Adrian V. Dalca , Juan Eugenio Iglesias

The claustrum is a thin gray matter structure in each brain hemisphere, characterized by exceptionally high connectivity with nearly all brain regions. Despite extensive animal studies on its anatomy and function and growing evidence of…

Neurons and Cognition · Quantitative Biology 2025-05-16 Steven Seung-Suk Kang , Joseph Bodenheimer , Kayley Morris , Tracey Butler

Retrospective analysis of brain MRI scans acquired in the clinic has the potential to enable neuroimaging studies with sample sizes much larger than those found in research datasets. However, analysing such clinical images "in the wild" is…

Image and Video Processing · Electrical Eng. & Systems 2023-01-06 Benjamin Billot , Magdamo Colin , Sean E. Arnold , Sudeshna Das , Juan. E. Iglesias

In the last two decades, neuroscience has produced intriguing evidence for a central role of the claustrum in mammalian forebrain structure and function. However, relatively few in vivo studies of the claustrum exist in humans. A reason for…

Image and Video Processing · Electrical Eng. & Systems 2023-05-24 Hongwei Li , Aurore Menegaux , Benita Schmitz-Koep , Antonia Neubauer , Felix JB Bäuerlein , Suprosanna Shit , Christian Sorg , Bjoern Menze , Dennis Hedderich

A large amount of manual segmentation is typically required to train a robust segmentation network so that it can segment objects of interest in a new imaging modality. The manual efforts can be alleviated if the manual segmentation in one…

Computer Vision and Pattern Recognition · Computer Science 2021-07-13 Bo Zhou , Chi Liu , James S. Duncan

In recent years, Deep Learning (DL) has shown promising results in conducting AI tasks such as computer vision and image segmentation. Specifically, Convolutional Neural Network (CNN) models in DL have been applied to prevention,detection,…

Image and Video Processing · Electrical Eng. & Systems 2019-11-19 Ahmed Awad Albishri , Syed Jawad Hussain Shah , Anthony Schmiedler , Seung Suk Kang , Yugyung Lee

Deep learning approaches to the segmentation of magnetic resonance images have shown significant promise in automating the quantitative analysis of brain images. However, a continuing challenge has been its sensitivity to the variability of…

Image and Video Processing · Electrical Eng. & Systems 2021-03-05 Dzung L. Pham , Yi-Yu Chou , Blake E. Dewey , Daniel S. Reich , John A. Butman , Snehashis Roy

Mitochondria segmentation in electron microscopy images is essential in neuroscience. However, due to the image degradation during the imaging process, the large variety of mitochondrial structures, as well as the presence of noise,…

Computer Vision and Pattern Recognition · Computer Science 2021-09-28 Zhili Li , Xuejin Chen , Jie Zhao , Zhiwei Xiong

Live cell culture is crucial in biomedical studies for analyzing cell properties and dynamics in vitro. This study focuses on segmenting unstained live cells imaged with bright-field microscopy. While many segmentation approaches exist for…

Quantitative Methods · Quantitative Biology 2025-08-26 Surajit Das , Gourav Roy , Pavel Zun

Ultrasound (US) image segmentation embraced its significant improvement in deep learning era. However, the lack of sharp boundaries in US images still remains an inherent challenge for segmentation. Previous methods often resort to global…

Image and Video Processing · Electrical Eng. & Systems 2020-10-13 Haoming Li , Xin Yang , Jiamin Liang , Wenlong Shi , Chaoyu Chen , Haoran Dou , Rui Li , Rui Gao , Guangquan Zhou , Jinghui Fang , Xiaowen Liang , Ruobing Huang , Alejandro Frangi , Zhiyi Chen , Dong Ni

Manual segmentation of medical images is labor intensive and especially challenging for images with poor contrast or resolution. The presence of disease exacerbates this further, increasing the need for an automated solution. To this…

Image and Video Processing · Electrical Eng. & Systems 2024-06-26 Selena Huisman , Matteo Maspero , Marielle Philippens , Joost Verhoeff , Szabolcs David

A key feature of magnetic resonance (MR) imaging is its ability to manipulate how the intrinsic tissue parameters of the anatomy ultimately contribute to the contrast properties of the final, acquired image. This flexibility, however, can…

Computer Vision and Pattern Recognition · Computer Science 2018-11-20 Dzung L. Pham , Snehashis Roy

Most existing algorithms for automatic 3D morphometry of human brain MRI scans are designed for data with near-isotropic voxels at approximately 1 mm resolution, and frequently have contrast constraints as well - typically requiring T1…

Image and Video Processing · Electrical Eng. & Systems 2020-12-25 Juan Eugenio Iglesias , Benjamin Billot , Yael Balbastre , Azadeh Tabari , John Conklin , Daniel C. Alexander , Polina Golland , Brian L. Edlow , Bruce Fischl

Accurate and efficient catheter segmentation in 3D ultrasound (US) is essential for cardiac intervention. Currently, the state-of-the-art segmentation algorithms are based on convolutional neural networks (CNNs), which achieved remarkable…

Computer Vision and Pattern Recognition · Computer Science 2022-02-01 Hongxu Yang , Caifeng Shan , Alexander F. Kolen , Peter H. N. de With

A key requirement for the success of supervised deep learning is a large labeled dataset - a condition that is difficult to meet in medical image analysis. Self-supervised learning (SSL) can help in this regard by providing a strategy to…

Computer Vision and Pattern Recognition · Computer Science 2020-11-02 Krishna Chaitanya , Ertunc Erdil , Neerav Karani , Ender Konukoglu

Segmentation has been a major task in neuroimaging. A large number of automated methods have been developed for segmenting healthy and diseased brain tissues. In recent years, deep learning techniques have attracted a lot of attention as a…

Image and Video Processing · Electrical Eng. & Systems 2019-07-05 Jimit Doshi , Guray Erus , Mohamad Habes , Christos Davatzikos

Anomaly segmentation, which localizes defective areas, is an important component in large-scale industrial manufacturing. However, most recent researches have focused on anomaly detection. This paper proposes a novel anomaly segmentation…

Image and Video Processing · Electrical Eng. & Systems 2021-10-08 Jouwon Song , Kyeongbo Kong , Ye-In Park , Seong-Gyun Kim , Suk-Ju Kang

Every year, millions of brain MRI scans are acquired in hospitals, which is a figure considerably larger than the size of any research dataset. Therefore, the ability to analyse such scans could transform neuroimaging research. Yet, their…

Image and Video Processing · Electrical Eng. & Systems 2023-03-29 Benjamin Billot , Colin Magdamo , You Cheng , Steven E. Arnold , Sudeshna Das , Juan. E. Iglesias

Planning of radiotherapy involves accurate segmentation of a large number of organs at risk, i.e. organs for which irradiation doses should be minimized to avoid important side effects of the therapy. We propose a deep learning method for…

Image and Video Processing · Electrical Eng. & Systems 2019-07-04 Pawel Mlynarski , Hervé Delingette , Hamza Alghamdi , Pierre-Yves Bondiau , Nicholas Ayache
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