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As with many tasks in engineering, structural design frequently involves navigating complex and computationally expensive problems. A prime example is the weight optimization of laminated composite materials, which to this day remains a…

Quantum Physics · Physics 2024-09-20 Arne Wulff , Boyang Chen , Matthew Steinberg , Yinglu Tang , Matthias Möller , Sebastian Feld

In light of major developments over the past decades in both quantum computing and simulations on classical hardware, it is a serious challenge to identify a real-world problem where quantum advantage is expected to appear. In quantum…

Molecular docking is an important tool for structure-based drug design, accelerating the efficiency of drug development. Complex and dynamic binding processes between proteins and small molecules require searching and sampling over a wide…

Chemical Physics · Physics 2024-02-23 Runqiu Shu , Bowen Liu , Zhaoping Xiong , Xiaopeng Cui , Yunting Li , Wei Cui , Man-Hong Yung , Nan Qiao

The recent physical realisation of quantum computers with dozens to hundreds of noisy qubits has given birth to an intense search for useful applications of their unique capabilities. One area that has received particular attention is…

Quantum Physics · Physics 2023-09-15 Maxwell T. West , Martin Sevior , Muhammad Usman

Design space exploration (DSE) plays an important role in optimising quantum circuit execution by systematically evaluating different configurations of compilation strategies and hardware settings. In this work, we study the impact of…

The development of tailored materials for specific applications is an active field of research in chemistry, material science and drug discovery. The number of possible molecules that can be obtained from a set of atomic species grow…

Quantum Layout Synthesis (QLS) plays a crucial role in optimizing quantum circuit execution on physical quantum devices. As we enter the era where quantum computers have hundreds of qubits, we are faced with scalability issues using optimal…

Quantum Physics · Physics 2024-12-05 Wan-Hsuan Lin , Jason Cong

Matrix multiplication (MatMul) is the computational backbone of modern machine learning, yet its classical complexity remains a bottleneck for large-scale data processing. We propose a hybrid quantum-classical algorithm for matrix…

Quantum Physics · Physics 2026-04-15 Wladimir Silva

Current quantum neural networks suffer from extreme sensitivity to both adversarial perturbations and hardware noise, creating a significant barrier to real-world deployment. Existing robustness techniques typically sacrifice clean accuracy…

Quantum Physics · Physics 2026-01-27 Mohamed Afane , Quanjiang Long , Haoting Shen , Ying Mao , Junaid Farooq , Ying Wang , Juntao Chen

Quantum computing has become increasingly practical in solving real-world problems due to advances in hardware and algorithms. In this paper, we aim to design and estimate quantum machine learning and hybrid quantum-classical models in a…

Quantum Physics · Physics 2025-07-14 Leyang Wang , Yilun Gong , Zongrui Pei

This paper introduces a novel quantum embedding search algorithm (QES, pronounced as "quest"), enabling search for optimal quantum embedding design for a specific dataset of interest. First, we establish the connection between the…

Quantum Physics · Physics 2022-04-20 Nam Nguyen , Kwang-Chen Chen

In this work, we design and implement VQ-LLM, an efficient fused Vector Quantization (VQ) kernel generation framework. We first introduce a software abstraction called codebook cache to optimize codebook access efficiency and support the…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-07-01 Zihan Liu , Xinhao Luo , Junxian Guo , Wentao Ni , Yangjie Zhou , Yue Guan , Cong Guo , Weihao Cui , Yu Feng , Minyi Guo , Yuhao Zhu , Minjia Zhang , Jingwen Leng , Chen Jin

Quantization has become a mainstream compression technique for reducing model size, computational requirements, and energy consumption for modern deep neural networks (DNNs). With improved numerical support in recent hardware, including…

Computer Vision and Pattern Recognition · Computer Science 2024-05-02 Jordan Dotzel , Gang Wu , Andrew Li , Muhammad Umar , Yun Ni , Mohamed S. Abdelfattah , Zhiru Zhang , Liqun Cheng , Martin G. Dixon , Norman P. Jouppi , Quoc V. Le , Sheng Li

Variational quantum algorithms exploit the features of superposition and entanglement to optimize a cost function efficiently by manipulating the quantum states. They are suitable for noisy intermediate-scale quantum (NISQ) computers that…

Quantum Physics · Physics 2023-08-29 Yunya Liu , Jiakun Liu , Jordan R. Raney , Pai Wang

Quantum computing has long promised to revolutionize the way we solve complex problems. At the same time, tensor networks are widely used across various fields due to their computational efficiency and capacity to represent intricate…

Quantum Physics · Physics 2024-12-10 Miquel Albertí Binimelis

Molecular docking is a critical computational method in drug discovery used to predict the binding conformation and orientation of a ligand within a protein's binding site. Mapping this challenge onto a graph-based problem, specifically the…

Quantum Physics · Physics 2026-04-27 Mathieu Garrigues , Victor Onofre , Wesley Coelho , S. Acheche

The co-design of neural network architectures, quantization precisions, and hardware accelerators offers a promising approach to achieving an optimal balance between performance and efficiency, particularly for model deployment on…

Computer Vision and Pattern Recognition · Computer Science 2025-01-10 Mingzi Wang , Yuan Meng , Chen Tang , Weixiang Zhang , Yijian Qin , Yang Yao , Yingxin Li , Tongtong Feng , Xin Wang , Xun Guan , Zhi Wang , Wenwu Zhu

Molecular docking (MD) is a crucial task in drug design, which predicts the position, orientation, and conformation of the ligand when bound to a target protein. It can be interpreted as a combinatorial optimization problem, where quantum…

Chemical Physics · Physics 2024-04-15 Yunting Li , Xiaopeng Cui , Zhaoping Xiong , Bowen Liu , Bi-Ying Wang , Runqiu Shu , Nan Qiao , Man-Hong Yung

Accurately and efficiently predicting the equilibrium geometries of large molecules remains a central challenge in quantum computational chemistry, even with hybrid quantum-classical algorithms. Two major obstacles hinder progress: the…

Quantum Physics · Physics 2026-04-07 Yajie Hao , Qiming Ding , Xiaoting Wang , Xiao Yuan

The Variational Quantum Eigensolver (VQE) is a promising algorithm for quantum computing applications in chemistry and materials science, particularly in addressing the limitations of classical methods for complex systems. This study…

Quantum Physics · Physics 2025-02-25 Nia Pollard , Kamal Choudhary
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