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The scarcity of high-quality annotated medical data, particularly in mental health, poses a significant bottleneck for training robust machine learning models. Privacy regulations restrict data sharing, making synthetic data generation a…

Retrieval-Augmented Generation (RAG) systems using Multimodal Large Language Models (MLLMs) show great promise for complex document understanding, yet their development is critically hampered by inadequate evaluation. Current benchmarks…

Computation and Language · Computer Science 2025-08-06 Wenxuan Shen , Mingjia Wang , Yaochen Wang , Dongping Chen , Junjie Yang , Yao Wan , Weiwei Lin

The recent success of large language models (LLMs) has paved the way for their adoption in the high-stakes domain of healthcare. Specifically, the application of LLMs in patient-trial matching, which involves assessing patient eligibility…

Artificial Intelligence · Computer Science 2023-12-18 Mauro Nievas , Aditya Basu , Yanshan Wang , Hrituraj Singh

Software vulnerability detection is generally supported by automated static analysis tools, which have recently been reinforced by deep learning (DL) models. However, despite the superior performance of DL-based approaches over rule-based…

Software Engineering · Computer Science 2024-05-03 Yanjing Yang , Xin Zhou , Runfeng Mao , Jinwei Xu , Lanxin Yang , Yu Zhangm , Haifeng Shen , He Zhang

Large Language Models (LLMs) have become a milestone in the field of artificial intelligence and natural language processing. However, their large-scale deployment remains constrained by the need for significant computational resources.…

Computation and Language · Computer Science 2025-08-07 Julián Camilo Velandia Gutiérrez

Large language models (LLMs) are increasingly touted as powerful tools for automating scientific information extraction. However, existing methods and tools often struggle with the realities of scientific literature: long-context documents,…

Current Large Language Models (LLMs) face inherent limitations due to their pre-defined context lengths, which impede their capacity for multi-hop reasoning within extensive textual contexts. While existing techniques like…

Computation and Language · Computer Science 2024-06-19 Weizhi Fei , Xueyan Niu , Guoqing Xie , Yanhua Zhang , Bo Bai , Lei Deng , Wei Han

This study presents a novel framework for smart search in digital archival systems, leveraging the capabilities of Large Language Models (LLMs) to enhance information retrieval. By employing a Retrieval-Augmented Generation (RAG) approach,…

Artificial Intelligence · Computer Science 2025-01-14 Ha Dung Nguyen , Thi-Hoang Anh Nguyen , Thanh Binh Nguyen

Large Language Models (LLMs) possess substantial reasoning capabilities and are increasingly applied to optimization tasks, particularly in synergy with evolutionary computation. However, while recent surveys have explored specific aspects…

Neural and Evolutionary Computing · Computer Science 2026-01-08 Yisong Zhang , Ran Cheng , Guoxing Yi , Kay Chen Tan

Large Language Models (LLMs) have exhibited impressive generation capabilities, but they suffer from hallucinations when solely relying on their internal knowledge, especially when answering questions that require less commonly known…

Computation and Language · Computer Science 2023-11-01 Wenting Zhao , Ye Liu , Tong Niu , Yao Wan , Philip S. Yu , Shafiq Joty , Yingbo Zhou , Semih Yavuz

Large language models (LLMs) often lack specialized knowledge for complex bioinformatics applications. We present a reproducible pipeline for fine-tuning LLMs on specialized bioinformatics data, demonstrated through two use cases: PRSGPT,…

Computation and Language · Computer Science 2026-01-21 Muhammad Muneeb , David B. Ascher

Retrieval-Augmented Generation (RAG) has recently demonstrated the performance of Large Language Models (LLMs) in the knowledge-intensive tasks such as Question-Answering (QA). RAG expands the query context by incorporating external…

Machine Learning · Computer Science 2024-06-18 Zijian Hei , Weiling Liu , Wenjie Ou , Juyi Qiao , Junming Jiao , Guowen Song , Ting Tian , Yi Lin

Recent technological advancements in data acquisition tools allowed life scientists to acquire multimodal data from different biological application domains. Broadly categorized in three types (i.e., sequences, images, and signals), these…

Quantitative Methods · Quantitative Biology 2020-03-03 Mufti Mahmud , M Shamim Kaiser , Amir Hussain

The development of synthesis procedures remains a fundamental challenge in materials discovery, with procedural knowledge scattered across decades of scientific literature in unstructured formats that are challenging for systematic…

The proliferation of complex structured data in hybrid sources, such as PDF documents and web pages, presents unique challenges for current Large Language Models (LLMs) and Multi-modal Large Language Models (MLLMs) in providing accurate…

Information Retrieval · Computer Science 2025-08-22 Shivani Upadhyay , Messiah Ataey , Syed Shariyar Murtaza , Yifan Nie , Jimmy Lin

Over recent years, an increasing amount of compute and data has been poured into training large language models (LLMs), usually by doing one-pass learning on as many tokens as possible randomly selected from large-scale web corpora. While…

Computation and Language · Computer Science 2023-08-24 Kushal Tirumala , Daniel Simig , Armen Aghajanyan , Ari S. Morcos

Purpose: Large Language Models (LLMs) hold significant promise for medical applications. Retrieval Augmented Generation (RAG) emerges as a promising approach for customizing domain knowledge in LLMs. This case study presents the development…

Background: Identification of the interactions and regulatory relations between biomolecules play pivotal roles in understanding complex biological systems and the mechanisms underlying diverse biological functions. However, the collection…

Computation and Language · Computer Science 2025-04-24 Gilchan Park , Byung-Jun Yoon , Xihaier Luo , Vanessa López-Marrero , Shinjae Yoo , Shantenu Jha

Large language models (LLMs) have rapidly advanced natural language processing, driving significant breakthroughs in tasks such as text generation, machine translation, and domain-specific reasoning. The field now faces a critical dilemma…

Computation and Language · Computer Science 2025-10-15 Jiya Manchanda , Laura Boettcher , Matheus Westphalen , Jasser Jasser

Large Language Models (LLMs) have demonstrated significant capabilities in understanding and generating human language, contributing to more natural interactions with complex systems. However, they face challenges such as ambiguity in user…

Computation and Language · Computer Science 2025-07-17 Ana Davila , Jacinto Colan , Yasuhisa Hasegawa