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Causal mediation analysis is widely used to investigate how causal effects operate through specific pathways linking treatments or exposures to outcomes. Recently, \texttt{crumble} was developed to enable nonparametric estimation of several…

Methodology · Statistics 2026-04-14 Richard Liu , Nicholas T. Williams , Kara E. Rudolph , Ivan Diaz

In social media platforms, user behavior is often influenced by interactions with other users, complicating the accurate estimation of causal effects in traditional A/B experiments. This study investigates situations where an individual's…

Social and Information Networks · Computer Science 2024-02-21 Lu Deng , Yilin Li , JingJing Zhang , Yong Wang , Chuan Chen

Causal effect estimation from observational data is one of the essential problems in causal inference. However, most estimation methods rely on the strong assumption that all confounders are observed, which is impractical and untestable in…

Methodology · Statistics 2023-02-14 Yubai Yuan , Annie Qu

Instrumental variables (IVs) are widely used for estimating causal effects in the presence of unmeasured confounding. Under the standard IV model, however, the average treatment effect (ATE) is only partially identifiable. To address this,…

Methodology · Statistics 2018-01-08 Linbo Wang , Eric Tchetgen Tchetgen

The synthetic control method (SCM) allows estimating the causal effect of an intervention in settings where panel data on a small number of treated and control units are available. We show that the existing SCM, as well as its extensions,…

Applications · Statistics 2022-05-20 Giovanni Mellace , Alessandra Pasquini

Recently, the separable indirect effect (SIE) has gained attention due to its identifiability without requiring the untestable cross-world assumption necessary for the natural indirect effect (NIE). This article systematically compares the…

Methodology · Statistics 2025-07-08 Yan-Lin Chen , Sheng-Hsuan Lin

Economists are often interested in the mechanisms by which a treatment affects an outcome. We develop tests for the "sharp null of full mediation" that a treatment $D$ affects an outcome $Y$ only through a particular mechanism (or set of…

Econometrics · Economics 2026-02-23 Soonwoo Kwon , Jonathan Roth

Qualitative interactions occur when a treatment effect or measure of association varies in sign by sub-population. Of particular interest in many biomedical settings are absence/presence qualitative interactions, which occur when an effect…

Methodology · Statistics 2020-10-20 Aaron Hudson , Ali Shojaie

Classical causal inference assumes treatments meant for a given unit do not have an effect on other units. This assumption is violated in interference problems, where new types of spillover causal effects arise, and causal inference becomes…

Methodology · Statistics 2024-09-30 Ilya Shpitser , Chan Park , Eric Tchetgen Tchetgen , Ryan Andrews

Treatment effect estimation can assist in effective decision-making in e-commerce, medicine, and education. One popular application of this estimation lies in the prediction of the impact of a treatment (e.g., a promotion) on an outcome…

Machine Learning · Computer Science 2023-09-26 Xiaofeng Lin , Guoxi Zhang , Xiaotian Lu , Han Bao , Koh Takeuchi , Hisashi Kashima

Estimating the total treatment effect (TTE) of a new feature in social platforms is crucial for understanding its impact on user behavior. However, the presence of network interference, which arises from user interactions, often complicates…

Applications · Statistics 2024-08-09 Yiming Jiang , Lu Deng , Yong Wang , He Wang

Natural experiments are a cornerstone of applied economics, providing settings for estimating causal effects with a compelling argument for treatment randomisation, but give little indication of the mechanisms behind causal effects. Causal…

Econometrics · Economics 2025-10-07 Senan Hogan-Hennessy

Interventional effects have been proposed as a solution to the unidentifiability of natural (in)direct effects under mediator-outcome confounders affected by the exposure. Such confounders are an intrinsic characteristic of studies with…

Methodology · Statistics 2022-03-30 Iván Díaz , Nicholas Williams , Kara E. Rudolph

Pairwise interactions between perturbations to a system can provide evidence for the causal dependencies of the underlying underlying mechanisms of a system. When observations are low dimensional, hand crafted measurements, detecting…

Machine Learning · Computer Science 2024-09-13 Zuheng , Xu , Moksh Jain , Ali Denton , Shawn Whitfield , Aniket Didolkar , Berton Earnshaw , Jason Hartford

We consider causal models with two observed variables and one latent variables, each variable being discrete, with the goal of characterizing the possible distributions on outcomes that can result from controlling one of the observed…

Information Theory · Computer Science 2021-03-05 Kevin Shu

Causal influences are at the core of any empirical science, the reason why its quantification is of paramount relevance for the mathematical theory of causality and applications. Quantum correlations, however, challenge our notion of cause…

Quantum Physics · Physics 2023-09-20 Lucas Hutter , Rafael Chaves , Ranieri Nery , George Moreno , Daniel J. Brod

Many open problems in machine learning are intrinsically related to causality, however, the use of causal analysis in machine learning is still in its early stage. Within a general reinforcement learning setting, we consider the problem of…

Machine Learning · Computer Science 2022-05-18 Tue Herlau , Rasmus Larsen

Questions concerning mediated causal effects are of great interest in psychology, cognitive science, medicine, social science, public health, and many other disciplines. For instance, about 60% of recent papers published in leading journals…

Statistics Theory · Mathematics 2013-03-05 Ilya Shpitser

Meta-analysis, by synthesizing effect estimates from multiple studies conducted in diverse settings, stands at the top of the evidence hierarchy in clinical research. Yet, conventional approaches based on fixed- or random-effects models…

Mediation analysis extending beyond single mediators has gained significant attention in recent years. However, related methods often assume the absence of unmeasured mediator-outcome confounding. To address this, we develop a mediation…

Methodology · Statistics 2026-03-31 Kang Shuai , Lan Liu , Yangbo He , Wei Li