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Various adaptive randomization procedures (adaptive designs) have been proposed to clinical trials. This paper discusses several broad families of procedures, such as the play-the-winner rule and Markov chain model, randomized…

Statistics Theory · Mathematics 2009-08-30 Li-Xin Zhang

Adaptive trials are now mainstream science. Recently, researchers have taken the adaptive trial concept to its natural conclusion, proposing what we call "Global Cumulative Treatment Analysis" (GCTA). Similar to the adaptive trial, decision…

Applications · Statistics 2013-08-06 Jeff Shrager

In this paper, we provide a general methodology to draw statistical inferences on individual signal coordinates or linear combinations of them in sparse phase retrieval. Given an initial estimator for the targeting parameter (some simple…

Methodology · Statistics 2020-09-29 Yisha Yao

Subgroup selection in clinical trials is essential for identifying patient groups that react differently to a treatment, thereby enabling personalised medicine. In particular, subgroup selection can identify patient groups that respond…

This paper studies the construction of adaptive confidence intervals under Huber's contamination model when the contamination proportion is unknown. For the robust confidence interval of a Gaussian mean, we show that the optimal length of…

Statistics Theory · Mathematics 2025-06-05 Yuetian Luo , Chao Gao

Artificial intelligence (AI)-based computer perception (CP) technologies use mobile sensors to collect behavioral and physiological data for clinical decision-making. These tools can reshape how clinical knowledge is generated and…

From scientific experiments to online A/B testing, the previously observed data often affects how future experiments are performed, which in turn affects which data will be collected. Such adaptivity introduces complex correlations between…

Machine Learning · Statistics 2018-01-03 Xinkun Nie , Xiaoying Tian , Jonathan Taylor , James Zou

The landscape of dose-finding designs for phase I clinical trials is rapidly shifting in the recent years, noticeably marked by the emergence of interval-based designs. We categorize them as the iDesigns and the IB-Designs. The iDesigns are…

Methodology · Statistics 2017-06-15 Yuan Ji , Shengjie Yang

Complex adaptive systems (CAS) are ubiquitous in nature. They are basic in social sciences. An overview of CAS is given with emphasize on the occurrence of bad side effects to seemingly wise decisions. Hence application to terrorism is…

Adaptation and Self-Organizing Systems · Physics 2007-05-23 E. Ahmed , A. S. Elgazzar , A. S. Hegazi

Adaptive Conformal Inference (ACI) provides finite-sample coverage guarantees, enhancing the prediction reliability under non-exchangeability. This study demonstrates that these desirable properties of ACI do not require the use of…

Machine Learning · Statistics 2025-07-02 Johan Hallberg Szabadváry , Tuwe Löfström

Prediction capability is considered an important issue in response surface methodology. Following the line of argument that a design should have several desirable properties we have extended an existing compound design criterion to include…

We consider the problem of constructing differentially private nonparametric confidence intervals (CIs) for an arbitrary quantity using resampling. A growing body of work has adapted resampling ideas to the private setting, including…

Cryptography and Security · Computer Science 2026-05-14 Tomer Shoham , Moshe Shenfeld , Noa Velner-Harris , Katrina Ligett

There are multiple cluster randomised trial designs that vary in when the clusters cross between control and intervention states, when observations are made within clusters, and how many observations are made at that time point. Identifying…

Methodology · Statistics 2023-07-20 Samuel I. Watson , Alan Girling , Karla Hemming

In the setting of high-dimensional linear models with Gaussian noise, we investigate the possibility of confidence statements connected to model selection. Although there exist numerous procedures for adaptive point estimation, the…

Statistics Theory · Mathematics 2009-10-07 Angelika Rohde , Lutz Duembgen

We consider the problem of constructing honest confidence intervals (CIs) for a scalar parameter of interest, such as the regression discontinuity parameter, in nonparametric regression based on kernel or local polynomial estimators. To…

Applications · Statistics 2020-04-08 Timothy B. Armstrong , Michal Kolesár

Estimating the effects of interventions in networks is complicated when the units are interacting, such that the outcomes for one unit may depend on the treatment assignment and behavior of many or all other units (i.e., there is…

Methodology · Statistics 2014-08-15 Dean Eckles , Brian Karrer , Johan Ugander

Background: Adaptive interventions provide a guide for using ongoing information about individuals to decide whether and how to modify the type, amount, delivery modality, or timing of treatment, to improve intervention effectiveness while…

Methodology · Statistics 2026-03-12 John J. Dziak , Inbal Nahum-Shani

We consider the problem of safe control in discrete autonomous agents that use learned components for imperfect perception (or more generally, state estimation) from high-dimensional observations. We propose a shield construction that…

Systems and Control · Electrical Eng. & Systems 2025-07-29 William Scarbro , Calum Imrie , Sinem Getir Yaman , Kavan Fatehi , Corina S. Pasareanu , Radu Calinescu , Ravi Mangal

This paper presents a mapping framework for design factors and implementation process for building credible Industrial Control Systems (ICS) security testbeds. The resilience of ICSs has become a critical concern to operators and…

Cryptography and Security · Computer Science 2019-11-06 Uchenna D Ani , Jeremy M Watson , Benjamin Green , Barnaby Craggs , Jason Nurse

We are sometimes forced to use the Interrupted Time Series (ITS) design as an identification strategy for potential policy change, such as when we only have a single treated unit and no comparable controls. For example, with recent county-…

Methodology · Statistics 2020-02-17 Luke Miratrix
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