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Research on long non-coding RNAs (lncRNAs) has garnered significant attention due to their critical roles in gene regulation and disease mechanisms. However, the complexity and diversity of lncRNA sequences, along with the limited knowledge…

Genomics · Quantitative Biology 2024-11-07 Wei Wang , Zhichao Hou , Xiaorui Liu , Xinxia Peng

Long non-coding RNAs (lncRNAs) are a class of non-coding RNAs which play a significant role in several biological processes. RNA-seq based transcriptome sequencing has been extensively used for identification of lncRNAs. However, accurate…

Genomics · Quantitative Biology 2019-02-15 S. Deshpande , J. Shuttleworth , J. Yang , S. Taramonli , M. England

Recent years have witnessed a substantial increase in the use of deep learning to solve various natural language processing (NLP) problems. Early deep learning models were constrained by their sequential or unidirectional nature, such that…

Information Retrieval · Computer Science 2024-03-05 Jiajia Wang , Jimmy X. Huang , Xinhui Tu , Junmei Wang , Angela J. Huang , Md Tahmid Rahman Laskar , Amran Bhuiyan

Long non-coding RNAs (lncRNAs) are important regulators to modulate gene expression and cell proliferation in the developing human brain. Previous methods mainly use bulk lncRNA and mRNA expression data to study lncRNA regulation. However,…

Molecular Networks · Quantitative Biology 2022-12-01 Meng Huang , Jiangtao Ma , Changzhou Long , Junpeng Zhang , Xiucai Ye , Tetsuya Sakurai

Long noncoding RNAs (lncRNAs) are a recently discovered class of non-protein coding RNAs which have now increasingly been shown to be involved in a wide variety of biological processes as regulatory molecules. Little is known regarding the…

Genomics · Quantitative Biology 2015-06-11 Saakshi Jalali , Deeksha Bhartiya , Vinod Scaria

Encoder-based transformer models are central to biomedical and clinical Natural Language Processing (NLP), as their bidirectional self-attention makes them well-suited for efficiently extracting structured information from unstructured text…

In the last decade, the discovery of noncoding RNA(ncRNA) has exploded. Classifying these ncRNA is critical todetermining their function. This thesis proposes a new methodemploying deep convolutional neural networks (CNNs) to classifyncRNA…

Computer Vision and Pattern Recognition · Computer Science 2021-02-11 Brian McClannahan , Cucong Zhong , Guanghui Wang

Deep transcriptome sequencing has revealed the existence of many transcripts that lack long or conserved open reading frames and which have been termed long non-coding RNAs (lncRNAs). Despite the existence of several well-characterized…

Genomics · Quantitative Biology 2014-10-02 Jorge Ruiz-Orera , Xavier Messeguer , Juan A. Subirana , M. Mar Albà

Transformer models have achieved great success across many NLP problems. However, previous studies in automated ICD coding concluded that these models fail to outperform some of the earlier solutions such as CNN-based models. In this paper…

Transformers-based models, such as BERT, have dramatically improved the performance for various natural language processing tasks. The clinical knowledge enriched model, namely ClinicalBERT, also achieved state-of-the-art results when…

Computation and Language · Computer Science 2022-04-18 Yikuan Li , Ramsey M. Wehbe , Faraz S. Ahmad , Hanyin Wang , Yuan Luo

Objective: Clinical knowledge enriched transformer models (e.g., ClinicalBERT) have state-of-the-art results on clinical NLP (natural language processing) tasks. One of the core limitations of these transformer models is the substantial…

Computation and Language · Computer Science 2023-01-30 Yikuan Li , Ramsey M. Wehbe , Faraz S. Ahmad , Hanyin Wang , Yuan Luo

BERT, which stands for Bidirectional Encoder Representations from Transformers, is a recently introduced language representation model based upon the transfer learning paradigm. We extend its fine-tuning procedure to address one of its…

Computation and Language · Computer Science 2019-10-25 Raghavendra Pappagari , Piotr Żelasko , Jesús Villalba , Yishay Carmiel , Najim Dehak

Recent innovations in architecture, pre-training, and fine-tuning have led to the remarkable in-context learning and reasoning abilities of large auto-regressive language models such as LLaMA and DeepSeek. In contrast, encoders like BERT…

Computation and Language · Computer Science 2025-06-10 Lola Le Breton , Quentin Fournier , Mariam El Mezouar , John X. Morris , Sarath Chandar

Recently, Natural Language Processing (NLP) has witnessed an impressive progress in many areas, due to the advent of novel, pretrained contextual representation models. In particular, Devlin et al. (2019) proposed a model, called BERT…

Computation and Language · Computer Science 2020-03-09 Debora Nozza , Federico Bianchi , Dirk Hovy

Biomedical text mining is becoming increasingly important as the number of biomedical documents rapidly grows. With the progress in natural language processing (NLP), extracting valuable information from biomedical literature has gained…

Computation and Language · Computer Science 2019-10-21 Jinhyuk Lee , Wonjin Yoon , Sungdong Kim , Donghyeon Kim , Sunkyu Kim , Chan Ho So , Jaewoo Kang

Bidirectional Encoder Representations from Transformers (BERT) has shown marvelous improvements across various NLP tasks, and consecutive variants have been proposed to further improve the performance of the pre-trained language models. In…

Computation and Language · Computer Science 2020-12-14 Yiming Cui , Wanxiang Che , Ting Liu , Bing Qin , Shijin Wang , Guoping Hu

Text classification algorithms investigate the intricate relationships between words or phrases and attempt to deduce the document's interpretation. In the last few years, these algorithms have progressed tremendously. Transformer…

Computation and Language · Computer Science 2022-06-28 Snehal Khandve , Vedangi Wagh , Apurva Wani , Isha Joshi , Raviraj Joshi

Developing high-performance entity normalization algorithms that can alleviate the term variation problem is of great interest to the biomedical community. Although deep learning-based methods have been successfully applied to biomedical…

Information Retrieval · Computer Science 2019-08-12 Zongcheng Ji , Qiang Wei , Hua Xu

The paper proposes to employ deep convolutional neural networks (CNNs) to classify noncoding RNA (ncRNA) sequences. To this end, we first propose an efficient approach to convert the RNA sequences into images characterizing their…

Computer Vision and Pattern Recognition · Computer Science 2020-08-25 Brian McClannahan , Krushi Patel , Usman Sajid , Cuncong Zhong , Guanghui Wang

In the global challenge of understanding and characterizing biodiversity, short species-specific genomic sequences known as DNA barcodes play a critical role, enabling fine-grained comparisons among organisms within the same kingdom of…

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