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Phenotype-driven gene prioritization is a critical process in the diagnosis of rare genetic disorders for identifying and ranking potential disease-causing genes based on observed physical traits or phenotypes. While traditional approaches…

Quantitative Methods · Quantitative Biology 2024-04-04 Junyoung Kim , Jingye Yang , Kai Wang , Chunhua Weng , Cong Liu

Machine Learning-guided solutions for protein learning tasks have made significant headway in recent years. However, success in scientific discovery tasks is limited by the accessibility of well-defined and labeled in-domain data. To tackle…

Machine Learning · Computer Science 2023-01-06 Ria Vinod , Pin-Yu Chen , Payel Das

Large Language Models (LLMs) have demonstrated remarkable abilities in text comprehension and logical reasoning, indicating that the text representations learned by LLMs can facilitate their language processing capabilities. In…

Artificial Intelligence · Computer Science 2025-01-16 Yuqi Ren , Renren Jin , Tongxuan Zhang , Deyi Xiong

With the rapid development of artificial intelligence, large language models (LLMs) have shown promising capabilities in mimicking human-level language comprehension and reasoning. This has sparked significant interest in applying LLMs to…

Computation and Language · Computer Science 2023-11-06 Mingze Yuan , Peng Bao , Jiajia Yuan , Yunhao Shen , Zifan Chen , Yi Xie , Jie Zhao , Yang Chen , Li Zhang , Lin Shen , Bin Dong

Human preference alignment can greatly enhance Multimodal Large Language Models (MLLMs), but collecting high-quality preference data is costly. A promising solution is the self-evolution strategy, where models are iteratively trained on…

Machine Learning · Computer Science 2024-12-23 Wentao Tan , Qiong Cao , Yibing Zhan , Chao Xue , Changxing Ding

Multimodal Large Language Models (MLLMs) have achieved remarkable progress but continue to struggle with geometric reasoning, primarily due to the perception bottleneck regarding fine-grained visual elements. While formal languages have…

Computer Vision and Pattern Recognition · Computer Science 2026-04-17 Peijie Wang , Ming-Liang Zhang , Jun Cao , Chao Deng , Dekang Ran , Hongda Sun , Pi Bu , Xuan Zhang , Yingyao Wang , Jun Song , Bo Zheng , Fei Yin , Cheng-Lin Liu

Multimodal Large Language Models (MLLMs) have demonstrated strong performance across a wide range of vision-language tasks, yet their internal processing dynamics remain underexplored. In this work, we introduce a probing framework to…

Computer Vision and Pattern Recognition · Computer Science 2025-08-29 Zhuoran Yu , Yong Jae Lee

Multimodal large language models (MLLMs) trained with visual instruction tuning have achieved strong performance across diverse tasks, yet they remain limited in vision-centric tasks such as object counting or spatial reasoning. We…

Computer Vision and Pattern Recognition · Computer Science 2025-10-13 Heeji Yoon , Jaewoo Jung , Junwan Kim , Hyungyu Choi , Heeseong Shin , Sangbeom Lim , Honggyu An , Chaehyun Kim , Jisang Han , Donghyun Kim , Chanho Eom , Sunghwan Hong , Seungryong Kim

This paper provides a comprehensive survey of the latest research on multilingual large language models (MLLMs). MLLMs not only are able to understand and generate language across linguistic boundaries, but also represent an important…

Computation and Language · Computer Science 2024-11-20 Shaolin Zhu , Supryadi , Shaoyang Xu , Haoran Sun , Leiyu Pan , Menglong Cui , Jiangcun Du , Renren Jin , António Branco , Deyi Xiong

Reasoning segmentation aims to segment target objects in complex scenes based on human intent and spatial reasoning. While recent multimodal large language models (MLLMs) have demonstrated impressive 2D image reasoning segmentation,…

Computer Vision and Pattern Recognition · Computer Science 2025-11-11 Jiaxin Huang , Runnan Chen , Ziwen Li , Zhengqing Gao , Xiao He , Yandong Guo , Mingming Gong , Tongliang Liu

Large language models (LLMs) have garnered significant attention for their superior performance in many knowledge-driven applications on the world wide web.These models are designed to train hundreds of millions or more parameters on large…

Computation and Language · Computer Science 2025-04-09 Bingchen Liu , Yuanyuan Fang , Naixing Xu , Shihao Hou , Xin Li , Qian Li

Large language models (LLMs) have substantially advanced machine learning research, including natural language processing, computer vision, data mining, etc., yet they still exhibit critical limitations in explainability, reliability,…

Machine Learning · Computer Science 2025-09-19 Xin Wang , Haoyang Li , Haibo Chen , Zeyang Zhang , Wenwu Zhu

Mathematical reasoning and optimization are fundamental to artificial intelligence and computational problem-solving. Recent advancements in Large Language Models (LLMs) have significantly improved AI-driven mathematical reasoning, theorem…

Artificial Intelligence · Computer Science 2025-03-25 Ali Forootani

In recent years, multimodal large language models (MLLMs) have made significant strides by training on vast high-quality image-text datasets, enabling them to generally understand images well. However, the inherent difficulty in explicitly…

Computer Vision and Pattern Recognition · Computer Science 2024-07-08 Yuanze Lin , Yunsheng Li , Dongdong Chen , Weijian Xu , Ronald Clark , Philip Torr , Lu Yuan

Recently, Large Language Models (LLMs) and Multimodal Large Language Models (MLLMs) have shown promise in instruction following and 2D image understanding. While these models are powerful, they have not yet been developed to comprehend the…

Computer Vision and Pattern Recognition · Computer Science 2023-12-22 Senqiao Yang , Jiaming Liu , Ray Zhang , Mingjie Pan , Zoey Guo , Xiaoqi Li , Zehui Chen , Peng Gao , Yandong Guo , Shanghang Zhang

The emergence of Multimodal Large Language Models (MLLMs) has revolutionized image understanding by bridging textual and visual modalities. However, these models often struggle with capturing fine-grained semantic information, such as the…

Computer Vision and Pattern Recognition · Computer Science 2025-07-16 Jie Yang , Wang Zeng , Sheng Jin , Lumin Xu , Wentao Liu , Chen Qian , Zhen Li , Ruimao Zhang

Scientific reasoning, the process through which humans apply logic, evidence, and critical thinking to explore and interpret scientific phenomena, is essential in advancing knowledge reasoning across diverse fields. However, despite…

Computation and Language · Computer Science 2026-04-21 Yibo Yan , Shen Wang , Jiahao Huo , Jingheng Ye , Zhendong Chu , Xuming Hu , Philip S. Yu , Carla Gomes , Bart Selman , Qingsong Wen

Large language models (LLMs) represent a significant advancement in integrating physical robots with AI-driven systems. We showcase the capabilities of our framework within the context of the real-world household competition. This research…

Robotics · Computer Science 2025-01-29 Shady Nasrat , Myungsu Kim , Seonil Lee , Jiho Lee , Yeoncheol Jang , Seung-joon Yi

The rapid advancement of large language models (LLMs) is transforming opportunities in geotechnical engineering, where workflows rely on complex, text-rich data. While general-purpose LLMs demonstrate strong reasoning capabilities, their…

Artificial Intelligence · Computer Science 2025-12-01 Lei Fan , Fangxue Liu , Cheng Chen

As large language models (LLMs) evolve, their integration with 3D spatial data (3D-LLMs) has seen rapid progress, offering unprecedented capabilities for understanding and interacting with physical spaces. This survey provides a…