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Mammalian cells are restricted from proliferating indefinitely. Telomeres at the end of each chromosome are shortened at cell division and, when they reach a critical length, the cell will enter permanent cell cycle arrest - a state known…
We propose that semiflexible polymers in poor solvent collapse in two stages. The first stage is the well known formation of a dense toroidal aggregate. However, if the solvent is sufficiently poor, the condensate will undergo a second…
Despite the widespread availability of generative AI tools in software engineering, developer adoption remains uneven. This unevenness is problematic because it hampers productivity efforts, frustrates management's expectations, and creates…
When polygenic traits are under stabilizing selection, many different combinations of alleles allow close adaptation to the optimum. If alleles have equal effects, all combinations that result in the same deviation from the optimum are…
Bulk n-type SrTiO3 (STO) has long been known to possess a superconducting ground state at an exceptionally dilute carrier density. This has raised questions about the applicability of the BCS-Eliashberg paradigm with its underlying…
We model the transcription factor based regulation network of yeast using a content-based network model that mimicks the recognition of binding motifs on the regulatory regions of the genes. We are thereby able to faithfully reproduce many…
We report a new mechanism for allelic dominance in regulatory genetic interactions that we call binding dominance. We investigated a biophysical model of gene regulation, where the fractional occupancy of a transcription factor (TF) on the…
We investigated the possibility of producing helium enhanced stars in globular clusters by accreting polluted matter during the pre-main sequence phase. We followed the evolution of two different classes of pre-main sequence accreting…
In this study, we delve into the intricate relationships between diabetes and a range of health indicators, with a particular focus on the newly added variable of income. Utilizing data from the 2015 Behavioral Risk Factor Surveillance…
Objective To conduct biomechanical analysis on the starting technique of male short-distance speed skating athletes in China and determine the key factors affecting the effectiveness of the starting movement. Methods 13 high-level male…
Noise in the expression of a gene produces fluctuations in the concentration of the gene product. These fluctuations can interfere with optimal function or can be exploited to generate beneficial diversity between cells; gene expression…
Clinical research should conform to high standards of ethical and scientific integrity, given that human lives are at stake. However, economic incentives can generate conflicts of interest for investigators, who may be inclined to withhold…
We examine how the institutional context affects the relationship between gender and opportunity entrepreneurship. To do this, we develop a multi-level model that connects feminist theory at the micro-level to institutional theory at the…
This study seeks to explore the relationship between entrepreneurship competencies and intention (EI) of a sample of potential STEM entrepreneurs in order to assess the conventional assumption on women exhibiting lower rates of…
A high number of embedded clusters is found in the Galaxy. Depending on the formation scenario, most of them can evolve to unbounded groups that are dissolved within a few tens of Myr. A systematic study of young stellar clusters showing…
Background: Advanced biological techniques have helped produce more insightful findings on the genetic etiology of infertility that may lead to better management of the condition. This review provides an update on genes predisposing to…
This work quantifies the effects of signaling and performing gender on the success of reviews written on the popular amazon shopping platform. Highly rated reviews play an important role in e-commerce since they are prominently displayed…
The purpose of the present study is to evaluate changes in chromatin of human buccal epithelium under the influence of stressing factor - dosed physical activity. Investigations were performed in a group of students (13 men) of age 19-23.…
Gene regulation in higher eukaryotes involves a complex interplay between the gene proximal promoter and distal genomic elements (such as enhancers) which work in concert to drive spatio-temporal expression. The experimental…
We examine whether gender norms - proxied by the outcome of Switzerland's 1981 public referendum on constitutional gender equality - continue to shape local female startup activity today, despite substantial population changes over the past…