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Medical image segmentation models built on Segment Anything Model (SAM) achieve strong performance on clean benchmarks, yet their reliability often degrades under realistic image corruptions such as noise, blur, motion artifacts, and…

Computer Vision and Pattern Recognition · Computer Science 2026-04-14 Jieru Li , Matthew Chen , Micky C. Nnamdi , J. Ben Tamo , Benoit L. Marteau , May D. Wang

The emerging field of connectomics aims to unlock the mysteries of the brain by understanding the connectivity between neurons. To map this connectivity, we acquire thousands of electron microscopy (EM) images with nanometer-scale…

Quantitative Methods · Quantitative Biology 2016-04-04 Stephen M. Plaza , Stuart E. Berg

Melanoma segmentation in Whole Slide Images (WSIs) is useful for prognosis and the measurement of crucial prognostic factors such as Breslow depth and primary invasive tumor size. In this paper, we present a novel approach that uses the…

Computer Vision and Pattern Recognition · Computer Science 2024-10-04 Qingyuan Liu , Avideh Zakhor

Tracking cells and detecting mitotic events in time-lapse microscopy image sequences is a crucial task in biomedical research. However, it remains highly challenging due to dividing objects, low signal-tonoise ratios, indistinct boundaries,…

Computer Vision and Pattern Recognition · Computer Science 2025-09-15 Zhu Chen , Mert Edgü , Er Jin , Johannes Stegmaier

In this work we present a method of automatic segmentation of defective skulls for custom cranial implant design and 3D printing purposes. Since such tissue models are usually required in patient cases with complex anatomical defects and…

Image and Video Processing · Electrical Eng. & Systems 2020-11-05 Oldřich Kodym , Michal Španěl , Adam Herout

This work introduces a new framework, ProtoSAM, for one-shot medical image segmentation. It combines the use of prototypical networks, known for few-shot segmentation, with SAM - a natural image foundation model. The method proposed creates…

Computer Vision and Pattern Recognition · Computer Science 2024-07-19 Lev Ayzenberg , Raja Giryes , Hayit Greenspan

Recent advancements in foundation models have shown significant potential in medical image analysis. However, there is still a gap in models specifically designed for medical image localization. To address this, we introduce MedLAM, a 3D…

Computer Vision and Pattern Recognition · Computer Science 2024-10-10 Wenhui Lei , Xu Wei , Xiaofan Zhang , Kang Li , Shaoting Zhang

The emergence of large models, also known as foundation models, has brought significant advancements to AI research. One such model is Segment Anything (SAM), which is designed for image segmentation tasks. However, as with other foundation…

Computer Vision and Pattern Recognition · Computer Science 2023-05-03 Tianrun Chen , Lanyun Zhu , Chaotao Ding , Runlong Cao , Yan Wang , Zejian Li , Lingyun Sun , Papa Mao , Ying Zang

Previous work has reported that vision foundation models show promising zero-shot performance in eye image segmentation. Here we examine whether the latest iteration of the Segment Anything Model, SAM3, offers better eye image segmentation…

Computer Vision and Pattern Recognition · Computer Science 2026-03-19 Diederick C. Niehorster , Marcus Nyström

The Segment Anything Model (SAM) is a powerful vision foundation model that is revolutionizing the traditional paradigm of segmentation. Despite this, a reliance on prompting each frame and large computational cost limit its usage in…

Computer Vision and Pattern Recognition · Computer Science 2024-07-03 Zijian Wu , Adam Schmidt , Peter Kazanzides , Septimiu E. Salcudean

Image segmentation is a long-standing challenge in computer vision, studied continuously over several decades, as evidenced by seminal algorithms such as N-Cut, FCN, and MaskFormer. With the advent of foundation models (FMs), contemporary…

Computer Vision and Pattern Recognition · Computer Science 2024-11-28 Tianfei Zhou , Wang Xia , Fei Zhang , Boyu Chang , Wenguan Wang , Ye Yuan , Ender Konukoglu , Daniel Cremers

Motion artifacts caused by prolonged acquisition time are a significant challenge in Magnetic Resonance Imaging (MRI), hindering accurate tissue segmentation. These artifacts appear as blurred images that mimic tissue-like appearances,…

Image and Video Processing · Electrical Eng. & Systems 2024-12-06 Sunyoung Jung , Yoonseok Choi , Mohammed A. Al-masni , Minyoung Jung , Dong-Hyun Kim

The recent wave of foundation models has witnessed tremendous success in computer vision (CV) and beyond, with the segment anything model (SAM) having sparked a passion for exploring task-agnostic visual foundation models. Empowered by its…

Computer Vision and Pattern Recognition · Computer Science 2024-08-19 Chunhui Zhang , Yawen Cui , Weilin Lin , Guanjie Huang , Yan Rong , Li Liu , Shiguang Shan

The alignment of serial-section electron microscopy (ssEM) images is critical for efforts in neuroscience that seek to reconstruct neuronal circuits. However, each ssEM plane contains densely packed structures that vary from one section to…

Computer Vision and Pattern Recognition · Computer Science 2017-12-06 Inwan Yoo , David G. C. Hildebrand , Willie F. Tobin , Wei-Chung Allen Lee , Won-Ki Jeong

Menisci are cartilaginous tissue found within the knee that contribute to joint lubrication and weight dispersal. Damage to menisci can lead to onset and progression of knee osteoarthritis (OA), a condition that is a leading cause of…

Image and Video Processing · Electrical Eng. & Systems 2025-04-25 Oliver Mills , Philip Conaghan , Nishant Ravikumar , Samuel Relton

While the Segment Anything Model (SAM) has achieved remarkable success in image segmentation, its direct application to medical imaging remains hindered by fundamental challenges, including ambiguous boundaries, insufficient modeling of…

Computer Vision and Pattern Recognition · Computer Science 2026-01-13 Yu Li , Da Chang , Xi Xiao

In this paper, we introduce Semantic-SAM, a universal image segmentation model to enable segment and recognize anything at any desired granularity. Our model offers two key advantages: semantic-awareness and granularity-abundance. To…

Computer Vision and Pattern Recognition · Computer Science 2023-07-11 Feng Li , Hao Zhang , Peize Sun , Xueyan Zou , Shilong Liu , Jianwei Yang , Chunyuan Li , Lei Zhang , Jianfeng Gao

Large foundation models, known for their strong zero-shot generalization capabilities, can be applied to a wide range of downstream tasks. However, developing foundation models for medical image segmentation poses a significant challenge…

Computer Vision and Pattern Recognition · Computer Science 2025-06-24 Sihan Yang , Jiadong Feng , Xuande Mi , Haixia Bi , Hai Zhang , Jian Sun

Semantic Segmentation is one of the most challenging vision tasks, usually requiring large amounts of training data with expensive pixel level annotations. With the success of foundation models and especially vision-language models, recent…

Computer Vision and Pattern Recognition · Computer Science 2024-09-17 Soroush Seifi , Daniel Olmeda Reino , Fabien Despinoy , Rahaf Aljundi

The Segment Anything Model (SAM), introduced to the computer vision community by Meta in April 2023, is a groundbreaking tool that allows automated segmentation of objects in images based on prompts such as text, clicks, or bounding boxes.…

Computer Vision and Pattern Recognition · Computer Science 2024-08-13 Athulya Sundaresan Geetha , Muhammad Hussain