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A clinical trial is an essential step in drug development, which is often costly and time-consuming. In silico trials are clinical trials conducted digitally through simulation and modeling as an alternative to traditional clinical trials.…

Quantitative Methods · Quantitative Biology 2022-09-20 Zifeng Wang , Chufan Gao , Lucas M. Glass , Jimeng Sun

Clinical auditing requires codified data for aggregation and analysis of patterns. However in the medical domain obtaining structured data can be difficult as the most natural, expressive and comprehensive way to record a clinical encounter…

Computers and Society · Computer Science 2016-06-14 Sedigheh Khademi , Christopher Palmer , Pari Delir Haghighi , Philip Lewis , Frada Burstein

In the emergency department (ED), patients undergo triage and multiple laboratory tests before diagnosis. This time-consuming process causes ED crowding which impacts patient mortality, medical errors, staff burnout, etc. This work proposes…

Computation and Language · Computer Science 2024-05-29 Liwen Sun , Abhineet Agarwal , Aaron Kornblith , Bin Yu , Chenyan Xiong

Clinical coding is a critical task in healthcare, although traditional methods for automating clinical coding may not provide sufficient explicit evidence for coders in production environments. This evidence is crucial, as medical coders…

Computation and Language · Computer Science 2025-04-08 Leonor Barreiros , Isabel Coutinho , Gonçalo M. Correia , Bruno Martins

Background: Empathy is widely recognized for improving patient outcomes, including reduced pain and anxiety and improved satisfaction, and its absence can cause harm. Meanwhile, use of artificial intelligence (AI)-based chatbots in…

Human-Computer Interaction · Computer Science 2026-02-06 Alastair Howcroft , Amber Bennett-Weston , Ahmad Khan , Joseff Griffiths , Simon Gay , Jeremy Howick

The main goal from this study is to discuss the main features of Artificial intelligence (AI) as well as their applicability for early cardiovascular Disease (CVDs) Detection, Material and Method : Systematic review approach Results : It…

Objective. Natural language processing methods for medical auto-coding, or automatic generation of medical billing codes from electronic health records, generally assign each code independently of the others. They may thus assign codes for…

Computation and Language · Computer Science 2015-10-19 Michael Subotin , Anthony R. Davis

People working with data often move their data across multiple applications, because they rely on these apps' complementing user experiences to best complete their tasks. Since traditional copy-and-paste approaches do not accommodate…

Human-Computer Interaction · Computer Science 2026-04-09 Priyan Vaithilingam , Elena L. Glassman , Nathalie Henry Riche , Gonzalo Ramos , Jeevana Priya Inala , Chenglong Wang

Healthcare AI holds the potential to increase patient safety, augment efficiency and improve patient outcomes, yet research is often limited by data access, cohort curation, and tooling for analysis. Collection and translation of electronic…

Software Engineering · Computer Science 2021-12-14 Raphael Y. Cohen , Vesela P. Kovacheva

Sample size calculations for power analysis are critical for clinical research and trial design, yet their complexity and reliance on statistical expertise create barriers for many researchers. We introduce PowerGPT, an AI-powered system…

The deployment of multiple AI-triage devices in radiology departments has grown rapidly, yet the cumulative impact on patient wait-times across different disease conditions remains poorly understood. This research develops a comprehensive…

Numerical Analysis · Mathematics 2025-11-03 Michelle Mastrianni , Rucha Deshpande , Frank W. Samuelson , Yee Lam Elim Thompson

Clinical trials constitute a critical yet exceptionally challenging and costly stage of drug development (\$2.6B per drug), where protocols are encoded as complex natural language documents, motivating the use of AI systems beyond manual…

Artificial Intelligence · Computer Science 2026-04-06 Sixue Xing , Kerui Wu , Xuanye Xia , Meng Jiang , Jintai Chen , Tianfan Fu

Computerised clinical coding approaches aim to automate the process of assigning a set of codes to medical records. While there is active research pushing the state of the art on clinical coding for hospitalized patients, the outpatient…

Outcome prediction from clinical text can prevent doctors from overlooking possible risks and help hospitals to plan capacities. We simulate patients at admission time, when decision support can be especially valuable, and contribute a…

Computation and Language · Computer Science 2021-02-09 Betty van Aken , Jens-Michalis Papaioannou , Manuel Mayrdorfer , Klemens Budde , Felix A. Gers , Alexander Löser

In the rapidly advancing field of artificial intelligence, software development has emerged as a key area of innovation. Despite the plethora of general-purpose AI assistants available, their effectiveness diminishes in complex,…

Software Engineering · Computer Science 2023-12-01 Gustavo Pinto , Cleidson de Souza , Thayssa Rocha , Igor Steinmacher , Alberto de Souza , Edward Monteiro

The research applies AI-driven code assistants to analyze a selection of influential computer code that has shaped modern technology, including email, internet browsing, robotics, and malicious software. The original contribution of this…

Machine Learning · Computer Science 2023-01-10 David Noever , Kevin Williams

Labeling training datasets has become a key barrier to building medical machine learning models. One strategy is to generate training labels programmatically, for example by applying natural language processing pipelines to text reports…

Generative AI has demonstrated strong potential in healthcare, from clinical decision support to patient-facing chatbots that improve outcomes. A critical challenge for deployment is effective human-AI communication, where content must be…

Computation and Language · Computer Science 2025-07-11 Hieu Tran , Zonghai Yao , Won Seok Jang , Sharmin Sultana , Allen Chang , Yuan Zhang , Hong Yu

Background: Advanced adaptive randomised clinical trials are increasingly used. Compared to their conventional counterparts, their flexibility may make them more efficient, increase the probability of obtaining conclusive results without…

In the modern healthcare system, rapidly expanding costs/complexity, the growing myriad of treatment options, and exploding information streams that often do not effectively reach the front lines hinder the ability to choose optimal…

Artificial Intelligence · Computer Science 2018-10-09 Casey C. Bennett , Kris Hauser
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