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Clinical reasoning agents based on large language models (LLMs) aim to automate tasks such as intensive care unit (ICU) monitoring and patient state tracking from electronic health records (EHRs). Existing systems typically rely on manually…

Artificial Intelligence · Computer Science 2026-05-12 Timothy Ossowski , Xinchi Liu , Danyal Maqbool , Vaibhav Dhanuka , Sheng Zhang , Hoifung Poon , Majid Afshar , Tyler Bradshaw , Junjie Hu

Healthcare providers usually record detailed notes of the clinical care delivered to each patient for clinical, research, and billing purposes. Due to the unstructured nature of these narratives, providers employ dedicated staff to assign…

Computation and Language · Computer Science 2022-08-03 Chufan Gao , Mononito Goswami , Jieshi Chen , Artur Dubrawski

The integration of artificial intelligence [AI] into clinical trials has revolutionized the process of drug development and personalized medicine. Among these advancements, deep learning and predictive modelling have emerged as…

Machine Learning · Computer Science 2024-12-11 Sydney Anuyah , Mallika K Singh , Hope Nyavor

This paper examines records retrieved from the ClinicalTrials.gov registry to characterize temporal trends in AI terminology and the geographical distribution of AI trials. The work also reports on an exploratory hybrid human-AI approach to…

Artificial Intelligence · Computer Science 2026-05-29 Sandra Woolley , Tim Collins , Khalid Khattak , Illia Chernomorets , Ariane Arevalo , Chris Richardson

We propose Artificial Intelligence Prospective Randomized Observer Blinding Evaluation (AI-PROBE) for quantitative clinical performance evaluation of radiology AI systems within prospective randomized clinical trials. AI-PROBE encompasses a…

Medical Physics · Physics 2020-03-02 Axel Wismüller , Larry Stockmaster

The International Classification of Diseases (ICD) is an authoritative medical classification system of different diseases and conditions for clinical and management purposes. ICD indexing assigns a subset of ICD codes to a medical record.…

Computation and Language · Computer Science 2024-05-30 Xindi Wang , Robert E. Mercer , Frank Rudzicz

Increasing clinical trial protocol complexity, amendments, and challenges around knowledge management create significant burden for trial teams. Structuring protocol content into standard formats has the potential to improve efficiency,…

Information Retrieval · Computer Science 2026-04-20 Ramtin Babaeipour , François Charest , Madison Wright

Developing artificial intelligence (AI) tools for healthcare is a collaborative effort, bringing data scientists, clinicians, patients and other disciplines together. In this paper, we explore the collaborative data practices of research…

Human-Computer Interaction · Computer Science 2024-01-17 Rafael Henkin , Elizabeth Remfry , Duncan J. Reynolds , Megan Clinch , Michael R. Barnes

Unstructured text from legal, medical, and administrative sources offers a rich but underutilized resource for research in public health and the social sciences. However, large-scale analysis is hampered by two key challenges: the presence…

Computation and Language · Computer Science 2025-07-16 Anders Ledberg , Anna Thalén

Ambient AI generates draft clinical notes from patient-clinician conversations, often using lay or consumer-oriented phrasing to support patient understanding instead of standardized clinical terminology. How clinicians revise these drafts…

Artificial Intelligence · Computer Science 2026-03-20 Ha Na Cho , Yawen Guo , Sairam Sutari , Emilie Chow , Steven Tam , Danielle Perret , Deepti Pandita , Kai Zheng

Clinical notes contain unstructured text provided by clinicians during patient encounters. These notes are usually accompanied by a sequence of diagnostic codes following the International Classification of Diseases (ICD). Correctly…

Machine Learning · Computer Science 2025-10-17 Mohammad Mansoori , Amira Soliman , Farzaneh Etminani

Artificial Intelligence (AI) has demonstrated potential in healthcare, particularly in enhancing diagnostic accuracy and decision-making through Clinical Decision Support Systems (CDSSs). However, the successful implementation of these…

Human-Computer Interaction · Computer Science 2025-01-29 Olya Rezaeian , Alparslan Emrah Bayrak , Onur Asan

Medical coding converts free-text clinical notes into standardized diagnostic and procedural codes, which are essential for billing, hospital operations, and medical research. Unlike ordinary text classification, it requires multi-step…

Artificial Intelligence · Computer Science 2025-11-18 Jiyang Zheng , Islam Nassar , Thanh Vu , Xu Zhong , Yang Lin , Tongliang Liu , Long Duong , Yuan-Fang Li

Despite the plethora of AI-based algorithms developed for anomaly detection in radiology, subsequent integration into clinical setting is rarely evaluated. In this work, we assess the applicability and utility of an AI-based model for brain…

Intensive care units (ICUs) are complex and data-rich environments. Data routinely collected in the ICUs provides tremendous opportunities for machine learning, but their use comes with significant challenges. Complex problems may require…

Human-Computer Interaction · Computer Science 2024-06-05 Marceli Wac , Raul Santos-Rodriguez , Chris McWilliams , Christopher Bourdeaux

Mapping clinical documents to standardised clinical vocabularies is an important task, as it provides structured data for information retrieval and analysis, which is essential to clinical research, hospital administration and improving…

Computation and Language · Computer Science 2025-09-15 Mingyang Li , Viktor Schlegel , Tingting Mu , Warren Del-Pinto , Goran Nenadic

Clinical information systems have become large repositories for semi-structured and partly annotated electronic health record data, which have reached a critical mass that makes them interesting for supervised data-driven neural network…

Computation and Language · Computer Science 2023-05-22 Markus Kreuzthaler , Bastian Pfeifer , Diether Kramer , Stefan Schulz

Background: Clinical natural language processing (NLP) refers to the use of computational methods for extracting, processing, and analyzing unstructured clinical text data, and holds a huge potential to transform healthcare in various…

The widespread adoption of EHRs following the HITECH Act has increased the clinician documentation burden, contributing to burnout. Emerging technologies, such as ambient listening tools powered by generative AI, offer real-time,…

Human-Computer Interaction · Computer Science 2025-04-22 Yawen Guo , Di Hu , Jiayuan Wang , Kai Zheng , Danielle Perret , Deepti Pandita , Steven Tam

This study reports the findings of qualitative interview sessions conducted with ICU clinicians for the co-design of a system user interface of an artificial intelligence (AI)-driven clinical decision support (CDS) system. This system…

Human-Computer Interaction · Computer Science 2025-03-13 Andrea E. Davidson , Jessica M. Ray , Ayush K. Patel , Yulia Strekalova Levites , Parisa Rashidi , Azra Bihorac