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Mild Cognitive Impairment (MCI) is an early stage of Alzheimer's disease (AD), a form of neurodegenerative disorder. Early identification of MCI is crucial for delaying its progression through timely interventions. Existing research has…

Audio and Speech Processing · Electrical Eng. & Systems 2024-10-18 Kristin Qi , Jiatong Shi , Caroline Summerour , John A. Batsis , Xiaohui Liang

Determining whether two graphs are isomorphic is a fundamental problem with practical applications in areas such as molecular chemistry or social network analysis, yet it remains a challenging task, with exact solutions often being…

Early detection of Mild Cognitive Impairment (MCI) leads to early interventions to slow the progression from MCI into dementia. Deep Learning (DL) algorithms could help achieve early non-invasive, low-cost detection of MCI. This paper…

Computer Vision and Pattern Recognition · Computer Science 2024-06-25 Muath Alsuhaibani , Hiroko H. Dodge , Mohammad H. Mahoor

Early diagnosis of Alzheimer's disease and its prodromal stage, also known as mild cognitive impairment (MCI), is critical since some patients with progressive MCI will develop the disease. We propose a multi-stream deep convolutional…

Image and Video Processing · Electrical Eng. & Systems 2023-08-01 Mona Ashtari-Majlan , Abbas Seifi , Mohammad Mahdi Dehshibi

Persistent homology is a method from computational algebraic topology that can be used to study the "shape" of data. We illustrate two filtrations --- the weight rank clique filtration and the Vietoris--Rips (VR) filtration --- that are…

Computational Geometry · Computer Science 2016-10-30 Bernadette J. Stolz , Heather A. Harrington , Mason A. Porter

The Vietoris-Rips filtration is a versatile tool in topological data analysis. It is a sequence of simplicial complexes built on a metric space to add topological structure to an otherwise disconnected set of points. It is widely used…

Computational Geometry · Computer Science 2013-03-07 Donald R. Sheehy

We propose the labeled \v{C}ech complex, the plain labeled Vietoris-Rips complex, and the locally scaled labeled Vietoris-Rips complex to perform persistent homology inference of decision boundaries in classification tasks. We provide…

Machine Learning · Statistics 2018-05-28 Karthikeyan Natesan Ramamurthy , Kush R. Varshney , Krishnan Mody

We use methods from computational algebraic topology to study functional brain networks, in which nodes represent brain regions and weighted edges encode the similarity of fMRI time series from each region. With these tools, which allow one…

Quantitative Methods · Quantitative Biology 2020-08-27 Bernadette J. Stolz , Tegan Emerson , Satu Nahkuri , Mason A. Porter , Heather A. Harrington

Early diagnosis of mild cognitive impairment (MCI) and subjective cognitive decline (SCD) utilizing multi-modal magnetic resonance imaging (MRI) is a pivotal area of research. While various regional and connectivity features from functional…

Image and Video Processing · Electrical Eng. & Systems 2024-01-17 Xiongri Shen , Zhenxi Song , Linling Li , Min Zhang , Lingyan Liang Honghai Liu , Demao Deng , Zhiguo Zhang

Brain network topology, derived from functional magnetic resonance imaging (fMRI), holds promise for improving Alzheimer's disease (AD) diagnosis. Current methods primarily focus on lower-order topological features, often overlooking the…

Geometric Topology · Mathematics 2025-09-19 Dengyi Zhao , Shanyong Li , Yunping Wang , Chenfei Wang , Zhiheng Zhou , Guiying Yan , Xingqin Qi

Persistent homology is a mathematical tool used for studying the shape of data by extracting its topological features. It has gained popularity in network science due to its applicability in various network mining problems, including…

Algebraic Topology · Mathematics 2023-06-21 Mehmet Emin Aktas , Thu Nguyen , Rakin Riza , Muhammad Ifte Islam , Esra Akbas

A challenge in computational topology is to deal with large filtered geometric complexes built from point cloud data such as Vietoris-Rips filtrations. This has led to the development of schemes for parallel computation and compression…

Algebraic Topology · Mathematics 2022-05-04 Bradley J. Nelson

The so-called Mild Cognitive Impairment (MCI) or cognitive loss appears in a previous stage before Alzheimer's Disease (AD), but it does not seem sufficiently severe to interfere in independent abilities of daily life, so it usually does…

We introduce the monoidal Rips filtration, a filtered simplicial set for weighted directed graphs and other lattice-valued networks. Our construction generalizes the Vietoris-Rips filtration for metric spaces by replacing the maximum…

Algebraic Topology · Mathematics 2025-10-29 Nello Blaser , Morten Brun , Odin Hoff Gardaa , Lars M. Salbu

Cross-subject motor imagery (CS-MI) classification in brain-computer interfaces (BCIs) is a challenging task due to the significant variability in Electroencephalography (EEG) patterns across different individuals. This variability often…

Machine Learning · Computer Science 2025-07-04 Ahmed G. Habashi , Ahmed M. Azab , Seif Eldawlatly , Gamal M. Aly

Deep machine learning models including Convolutional Neural Networks (CNN) have been successful in the detection of Mild Cognitive Impairment (MCI) using medical images, questionnaires, and videos. This paper proposes a novel Multi-branch…

Computer Vision and Pattern Recognition · Computer Science 2024-01-08 Jian Sun , Hiroko H. Dodge , Mohammad H. Mahoor

Brain connectivity alternations associated with brain disorders have been widely reported in resting-state functional imaging (rs-fMRI) and diffusion tensor imaging (DTI). While many dual-modal fusion methods based on graph neural networks…

Computer Vision and Pattern Recognition · Computer Science 2024-11-14 Feiyu Yin , Yu Lei , Siyuan Dai , Wenwen Zeng , Guoqing Wu , Liang Zhan , Jinhua Yu

Patients initially diagnosed with early mild cognitive impairment (eMCI) are known to be a clinically heterogeneous group with very subtle patterns of brain atrophy. To examine the boarders between normal controls (NC) and eMCI, Magnetic…

Image and Video Processing · Electrical Eng. & Systems 2019-07-16 Can Gafuroglu , Islem Rekik

Functional magnetic resonance imaging (fMRI) is a crucial technology for gaining insights into cognitive processes in humans. Data amassed from fMRI measurements result in volumetric data sets that vary over time. However, analysing such…

Neurons and Cognition · Quantitative Biology 2020-10-23 Bastian Rieck , Tristan Yates , Christian Bock , Karsten Borgwardt , Guy Wolf , Nicholas Turk-Browne , Smita Krishnaswamy

In the applied algebraic topology community, the persistent homology induced by the Vietoris-Rips simplicial filtration is a standard method for capturing topological information from metric spaces. In this paper, we consider a different,…

Algebraic Topology · Mathematics 2024-04-24 Sunhyuk Lim , Facundo Memoli , Osman Berat Okutan