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Scaling laws have allowed Pre-trained Language Models (PLMs) into the field of causal reasoning. Causal reasoning of PLM relies solely on text-based descriptions, in contrast to causal discovery which aims to determine the causal…

Large pre-trained language models (LMs) have been shown to perform surprisingly well when fine-tuned on tasks that require commonsense and world knowledge. However, in end-to-end architectures, it is difficult to explain what is the…

Computation and Language · Computer Science 2020-04-14 Veronica Latcinnik , Jonathan Berant

Large language models (LLMs) effectively generate fluent text when the target output follows natural language patterns. However, structured prediction tasks confine the output format to a limited ontology, causing even very large models to…

Computation and Language · Computer Science 2023-10-19 Derek Chen , Celine Lee , Yunan Lu , Domenic Rosati , Zhou Yu

Large Language Models (LLMs) have shown increasing potential in automating model-driven software engineering tasks, particularly in generating models conforming to Domain Specific Languages (DSLs) from natural language. While most existing…

Software Engineering · Computer Science 2026-05-18 Junaid Baber , Nicolas Hili , Didier Schwab , Léo Challier , Cécilia Satrin

With the increasing interest in robotic synthesis in the context of organic chemistry, the automated extraction of chemical procedures from literature is critical. However, this task remains challenging due to the inherent ambiguity of…

Artificial Intelligence · Computer Science 2025-07-02 Yu Zhang , Ruijie Yu , Jidong Tian , Feng Zhu , Jiapeng Liu , Xiaokang Yang , Yaohui Jin , Yanyan Xu

Adapter parameters provide a mechanism to modify the behavior of machine learning models and have gained significant popularity in the context of large language models (LLMs) and generative AI. These parameters can be merged to support…

Computation and Language · Computer Science 2026-03-13 Ondrej Bohdal , Mete Ozay , Jijoong Moon , Kyeng-Hun Lee , Hyeonmok Ko , Umberto Michieli

Multimodal Large Language Models (MLLMs) have seen growing adoption across various scientific disciplines. These advancements encourage the investigation of molecule-text modeling within synthetic chemistry, a field dedicated to designing…

Machine Learning · Computer Science 2024-06-21 He Cao , Yanjun Shao , Zhiyuan Liu , Zijing Liu , Xiangru Tang , Yuan Yao , Yu Li

Low-resource languages (LRLs) face significant challenges in natural language processing (NLP) due to limited data. While current state-of-the-art large language models (LLMs) still struggle with LRLs, smaller multilingual models (mLMs)…

Computation and Language · Computer Science 2025-02-17 Daniil Gurgurov , Ivan Vykopal , Josef van Genabith , Simon Ostermann

With the emergence of diffusion models as a frontline generative model, many researchers have proposed molecule generation techniques with conditional diffusion models. However, the unavoidable discreteness of a molecule makes it difficult…

Machine Learning · Computer Science 2025-06-05 Jinho Chang , Jong Chul Ye

Recently, deep generative models have revealed itself as a promising way of performing de novo molecule design. However, previous research has focused mainly on generating SMILES strings instead of molecular graphs. Although current graph…

Quantitative Methods · Quantitative Biology 2018-04-24 Yibo Li , Liangren Zhang , Zhenming Liu

Causal Language Modeling (CLM) and Masked Language Modeling (MLM) are two mainstream learning paradigms based on Transformer networks, specifically the Decoder-only and Encoder-only architectures. The strengths of each paradigm in…

Computation and Language · Computer Science 2024-12-05 Xinru Yu , Bin Guo , Shiwei Luo , Jie Wang , Tao Ji , Yuanbin Wu

Large decoder-only language models (LLMs) have achieved remarkable success in generation and reasoning tasks, where they generate text responses given instructions. However, many applications, e.g., retrieval augmented generation (RAG),…

Computation and Language · Computer Science 2025-06-06 Caojin Zhang , Qiang Zhang , Ke Li , Sai Vidyaranya Nuthalapati , Benyu Zhang , Jason Liu , Serena Li , Lizhu Zhang , Xiangjun Fan

With recent advances in large language models (LLMs), the concept of automatically generating children's educational materials has become increasingly realistic. Working toward the goal of age-appropriate simplicity in generated educational…

Computation and Language · Computer Science 2023-10-31 Maria Valentini , Jennifer Weber , Jesus Salcido , Téa Wright , Eliana Colunga , Katharina Kann

The rapid evolution of artificial intelligence in drug discovery encounters challenges with generalization and extensive training, yet Large Language Models (LLMs) offer promise in reshaping interactions with complex molecular data. Our…

Biomolecules · Quantitative Biology 2024-12-20 He Cao , Zijing Liu , Xingyu Lu , Yuan Yao , Yu Li

Active learning (AL) accelerates scientific discovery by prioritizing the most informative experiments, but traditional machine learning (ML) models used in AL suffer from cold-start limitations and domain-specific feature engineering,…

Machine Learning · Computer Science 2025-12-05 Hongchen Wang , Rafael Espinosa Castañeda , Jay R. Werber , Yao Fehlis , Edward Kim , Jason Hattrick-Simpers

Molecule design is a multifaceted approach that leverages computational methods and experiments to optimize molecular properties, fast-tracking new drug discoveries, innovative material development, and more efficient chemical processes.…

Computation and Language · Computer Science 2024-08-23 Sakhinana Sagar Srinivas , Venkataramana Runkana

Large Language Models (LLMs) are reshaping unsupervised learning by offering an unprecedented ability to perform text clustering based on their deep semantic understanding. However, their direct application is fundamentally limited by a…

Computation and Language · Computer Science 2026-04-08 Yuanjie Zhu , Liangwei Yang , Ke Xu , Weizhi Zhang , Zihe Song , Jindong Wang , Philip S. Yu

Language Models (LMs) have greatly influenced diverse domains. However, their inherent limitation in comprehending 3D molecular structures has considerably constrained their potential in the biomolecular domain. To bridge this gap, we focus…

Machine Learning · Computer Science 2024-03-19 Sihang Li , Zhiyuan Liu , Yanchen Luo , Xiang Wang , Xiangnan He , Kenji Kawaguchi , Tat-Seng Chua , Qi Tian

There is increasing adoption of artificial intelligence in drug discovery. However, existing studies use machine learning to mainly utilize the chemical structures of molecules but ignore the vast textual knowledge available in chemistry.…

Machine Learning · Computer Science 2024-01-31 Shengchao Liu , Weili Nie , Chengpeng Wang , Jiarui Lu , Zhuoran Qiao , Ling Liu , Jian Tang , Chaowei Xiao , Anima Anandkumar

Generative approaches powered by large language models (LLMs) have demonstrated emergent abilities in tasks that require complex reasoning abilities. Yet the generative nature still makes the generated content suffer from hallucinations,…

Computation and Language · Computer Science 2023-11-07 Zilin Xiao , Ming Gong , Jie Wu , Xingyao Zhang , Linjun Shou , Jian Pei , Daxin Jiang
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