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Protein representation learning is critical in various tasks in biology, such as drug design and protein structure or function prediction, which has primarily benefited from protein language models and graph neural networks. These models…

Contrastive learning models have demonstrated impressive abilities to capture semantic similarities by aligning representations in the embedding space. However, their performance can be limited by the quality of the training data and its…

Direct Preference Optimization (DPO) has shown promising results in aligning generative outputs with human preferences by distinguishing between chosen and rejected samples. However, a critical limitation of DPO is likelihood displacement,…

Fairness in Continual Learning for Large Multimodal Models (LMMs) is an emerging yet underexplored challenge, particularly in the presence of imbalanced data distributions that can lead to biased model updates and suboptimal performance…

Direct Preference Optimization (DPO) is broadly utilized for aligning Large Language Models (LLMs) with human values because of its flexibility. Despite its effectiveness, it has been observed that the capability of DPO to generate…

Direct Preference Optimization (DPO) has emerged as a prominent algorithm for the direct and robust alignment of Large Language Models (LLMs) with human preferences, offering a more straightforward alternative to the complex Reinforcement…

Large language models (LLMs) are fine-tuned using human comparison data with Reinforcement Learning from Human Feedback (RLHF) methods to make them better aligned with users' preferences. In contrast to LLMs, human preference learning has…

Fine-tuning pre-trained Large Language Models (LLMs) is essential to align them with human values and intentions. This process often utilizes methods like pairwise comparisons and KL divergence against a reference LLM, focusing on the…

Direct Preference Optimization (DPO), which derives reward signals directly from pairwise preference data, has shown its effectiveness on aligning Large Language Models (LLMs) with human preferences. Despite its widespread use across…

Generating accurate glyphs for visual text rendering is essential yet challenging. Existing methods typically enhance text rendering by training on a large amount of high-quality scene text images, but the limited coverage of glyph…

Direct Preference Optimization (DPO) is a method for enhancing model performance by directly optimizing for the preferences or rankings of outcomes, instead of traditional loss functions. This approach has proven effective in aligning Large…

Large Language Models (LLMs) have become increasingly popular due to their ability to process and generate natural language. However, as they are trained on massive datasets of text, LLMs can inherit harmful biases and produce outputs that…

We study an LLM fine-tuning task for designing reward functions for sequential resource allocation problems in public health, guided by human preferences expressed in natural language. This setting presents a challenging testbed for…

Structure-based drug design (SBDD) aims to efficiently discover high-affinity ligands within vast chemical spaces. However, current generative models struggle with objective misalignment and rigid sampling budgets. We present MolFORM, a…

Aligning large language models with human preferences is crucial for their safe deployment. While Direct Preference Optimization (DPO) offers an efficient alternative to reinforcement learning from human feedback, traditional DPO methods…

Direct Preference Optimization (DPO) has emerged as an important approach for learning from human preferences in aligning large language models (LLMs). However, collecting human preference data is costly and inefficient, motivating methods…

Despite considerable progress, ab initio protein structure prediction remains suboptimal. A crowdsourcing approach is the online puzzle video game Foldit, that provided several useful results that matched or even outperformed…

Direct Preference Optimization (DPO) has emerged as an effective approach for aligning large language models (LLMs) with human preferences. However, its performance is highly dependent on the quality of the underlying human preference data.…

Post-training alignment of diffusion models relies on simplified signals, such as scalar rewards or binary preferences. This limits alignment with complex human expertise, which is hierarchical and fine-grained. To address this, we first…

Proteins are the fundamental macromolecules that play diverse and crucial roles in all living matter and have tremendous implications in healthcare, manufacturing, and biotechnology. Their functions are largely determined by the sequences…