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Optical microscopy is without a doubt an essential component of life science research, but many objects of interest in biology are transparent. Chemical or immunological dyes, which can often be toxic, fluorescent transgenes, which require…

Optics · Physics 2012-09-11 Quintin Tyrell Davis

State-of-the-art image classifiers are trained and tested using well-illuminated images. These images are typically captured by CMOS image sensors with at least tens of photons per pixel. However, in dark environments when the photon flux…

Image and Video Processing · Electrical Eng. & Systems 2020-07-20 Abhiram Gnanasambandam , Stanley H. Chan

We introduce a neural network-based method to denoise pairs of images taken in quick succession, with and without a flash, in low-light environments. Our goal is to produce a high-quality rendering of the scene that preserves the color and…

Computer Vision and Pattern Recognition · Computer Science 2021-04-16 Zhihao Xia , Michaël Gharbi , Federico Perazzi , Kalyan Sunkavalli , Ayan Chakrabarti

Fluorescence microscopy has been a significant tool to observe long-term imaging of embryos (in vivo) growth over time. However, cumulative exposure is phototoxic to such sensitive live samples. While techniques like light-sheet…

Image and Video Processing · Electrical Eng. & Systems 2022-01-05 Varun Mannam , Jacob Brandt , Cody J. Smith , Scott Howard

Achieving fast, large-scale volumetric imaging with micrometer resolution has been a persistent challenge in the field of biological microscopy. To address this challenge, we report an augmented version of light field microscopy,…

Optics · Physics 2024-10-11 Aymerick Bazin , Amaury Badon

The mathematical theory of compressed sensing (CS) asserts that one can acquire signals from measurements whose rate is much lower than the total bandwidth. Whereas the CS theory is now well developed, challenges concerning hardware…

Information Theory · Computer Science 2013-07-18 Makhlad Chahid , Jerome Bobin , Hamed Shams Mousavi , Emmanuel Candes , Maxime Dahan , Vincent Studer

We demonstrate accurate phase measurement from low photon level interference data using a constrained optimization method that takes into account the expected redundancy in the unknown phase function. This approach is shown to have…

Quantum Physics · Physics 2015-06-23 Mandeep Singh , Kedar Khare , Anand Kumar Jha , Shashi Prabhakar , R. P. Singh

This article reviews deep learning applications in biomedical optics with a particular emphasis on image formation. The review is organized by imaging domains within biomedical optics and includes microscopy, fluorescence lifetime imaging,…

Fundamental properties of light unavoidably impose features on images collected using fluorescence microscopes. Modeling these features is ever more important in quantitatively interpreting microscopy images collected at scales on par or…

Low-light image enhancement (LLIE) aims at improving the perception or interpretability of an image captured in an environment with poor illumination. Recent advances in this area are dominated by deep learning-based solutions, where many…

Computer Vision and Pattern Recognition · Computer Science 2021-11-08 Chongyi Li , Chunle Guo , Linghao Han , Jun Jiang , Ming-Ming Cheng , Jinwei Gu , Chen Change Loy

Mid-infrared photothermal microscopy is a new chemical imaging technology in which a visible beam senses the photothermal effect induced by a pulsed infrared laser. This technology provides infrared spectroscopic information at sub-micron…

Optics · Physics 2021-04-08 Yi Zhang , Haonan Zong , Cheng Zong , Yuying Tan , Meng Zhang , Yuewei Zhan , Ji-Xin Cheng

Maritime images captured under low-light imaging condition easily suffer from low visibility and unexpected noise, leading to negative effects on maritime traffic supervision and management. To promote imaging performance, it is necessary…

Image and Video Processing · Electrical Eng. & Systems 2020-08-11 Yu Guo , Yuxu Lu , Ryan Wen Liu , Meifang Yang , Kwok Tai Chui

Time-of-Flight (ToF) cameras require active illumination to obtain depth information thus the power of illumination directly affects the performance of ToF cameras. Traditional ToF imaging algorithms is very sensitive to illumination and…

Computer Vision and Pattern Recognition · Computer Science 2018-12-20 Yan Chen , Jimmy Ren , Xuanye Cheng , Keyuan Qian , Jinwei Gu

Unlike single image task, stereo image enhancement can use another view information, and its key stage is how to perform cross-view feature interaction to extract useful information from another view. However, complex noise in low-light…

Computer Vision and Pattern Recognition · Computer Science 2024-01-17 Minghua Zhao , Xiangdong Qin , Shuangli Du , Xuefei Bai , Jiahao Lyu , Yiguang Liu

We report on the recently emerging (Laser) Light Sheet based Fluorescence Microscopy field (LSFM). The techniques used in this field allow to study and visualize biomedical objects non-destructively in high-resolution through virtual…

Instrumentation and Detectors · Physics 2011-06-17 Jan A. N. Buytaert , Emilie Descamps , Dominique Adriaens , Joris J. J. Dirckx

In digital imaging, enhancing visual content in poorly lit environments is a significant challenge, as images often suffer from inadequate brightness, hidden details, and an overall reduction in quality. This issue is especially critical in…

Computer Vision and Pattern Recognition · Computer Science 2023-12-27 Farzaneh Koohestani , Nader Karimi , Shadrokh Samavi

Low-light image enhancement is challenging in that it needs to consider not only brightness recovery but also complex issues like color distortion and noise, which usually hide in the dark. Simply adjusting the brightness of a low-light…

Image and Video Processing · Electrical Eng. & Systems 2020-03-17 Feifan Lv , Yu Li , Feng Lu

In this paper, we propose a novel low-light image enhancement method aimed at improving the performance of recognition models. Despite recent advances in deep learning, the recognition of images under low-light conditions remains a…

Computer Vision and Pattern Recognition · Computer Science 2025-01-09 Seitaro Ono , Yuka Ogino , Takahiro Toizumi , Atsushi Ito , Masato Tsukada

Enhancing the visibility in extreme low-light environments is a challenging task. Under nearly lightless condition, existing image denoising methods could easily break down due to significantly low SNR. In this paper, we systematically…

Image and Video Processing · Electrical Eng. & Systems 2021-08-05 Kaixuan Wei , Ying Fu , Yinqiang Zheng , Jiaolong Yang

In this work a quantum imaging setup based on undetected squeezed photons is employed for metrological applications such as sensitive phase measurement and quantum imaging. In spite of the traditional quantum imaging with undetected…

Quantum Physics · Physics 2025-06-10 S. Samimi , Z. Ghasemi , H. Mohammadi