English
Related papers

Related papers: DNAHLM -- DNA sequence and Human Language mixed la…

200 papers

Large-scale language models such as DNABert and LOGO aim to learn optimal gene representations and are trained on the entire Human Reference Genome. However, standard tokenization schemes involve a simple sliding window of tokens like…

Computation and Language · Computer Science 2023-10-16 Soumyadeep Roy , Jonas Wallat , Sowmya S Sundaram , Wolfgang Nejdl , Niloy Ganguly

Protein is linked to almost every life process. Therefore, analyzing the biological structure and property of protein sequences is critical to the exploration of life, as well as disease detection and drug discovery. Traditional protein…

Machine Learning · Computer Science 2021-12-08 Yijia Xiao , Jiezhong Qiu , Ziang Li , Chang-Yu Hsieh , Jie Tang

Language models have steadily increased in size over the past few years. They achieve a high level of performance on various natural language processing (NLP) tasks such as question answering and summarization. Large language models (LLMs)…

Computation and Language · Computer Science 2023-01-31 Jessica Huynh , Cathy Jiao , Prakhar Gupta , Shikib Mehri , Payal Bajaj , Vishrav Chaudhary , Maxine Eskenazi

High-throughput phenotyping, the automated mapping of patient signs and symptoms to standardized ontology concepts, is essential to gaining value from electronic health records (EHR) in the support of precision medicine. Despite…

Artificial Intelligence · Computer Science 2024-06-24 Syed I. Munzir , Daniel B. Hier , Chelsea Oommen , Michael D. Carrithers

The general trace reconstruction problem seeks to recover an original sequence from its noisy copies independently corrupted by deletions, insertions, and substitutions. This problem arises in applications such as DNA data storage, a…

Machine Learning · Computer Science 2025-07-18 Franziska Weindel , Michael Girsch , Reinhard Heckel

Recent advancements in specialized large-scale architectures for training image and language have profoundly impacted the field of computer vision and natural language processing (NLP). Language models, such as the recent ChatGPT and GPT4…

Biomolecules · Quantitative Biology 2023-05-04 Sergio Romero-Romero , Sebastian Lindner , Noelia Ferruz

Scaling language models with more data, compute and parameters has driven significant progress in natural language processing. For example, thanks to scaling, GPT-3 was able to achieve strong results on in-context learning tasks. However,…

Generative artificial intelligence attracts significant attention, especially with the introduction of large language models. Its capabilities are being exploited to solve various software engineering tasks. Thanks to their ability to…

Software Engineering · Computer Science 2026-02-06 Lukas Radosky , Ivan Polasek

Foundation models have revolutionized natural language processing and artificial intelligence, significantly enhancing how machines comprehend and generate human languages. Inspired by the success of these foundation models, researchers…

Large Language Models (LLMs) demonstrate remarkable generalizability across diverse tasks, yet genomic foundation models (GFMs) still require separate finetuning for each downstream application, creating significant overhead as model sizes…

Genomics · Quantitative Biology 2025-02-07 Zehui Li , Vallijah Subasri , Yifei Shen , Dongsheng Li , Yiren Zhao , Guy-Bart Stan , Caihua Shan

Large Language Models (LLMs) are revolutionizing bioinformatics, enabling advanced analysis of DNA, RNA, proteins, and single-cell data. This survey provides a systematic review of recent advancements, focusing on genomic sequence modeling,…

Computation and Language · Computer Science 2026-03-03 Zhenyu Wang , Zikang Wang , Jiyue Jiang , Pengan Chen , Xiangyu Shi , Yu Li

Large language models (LLMs) have demonstrated remarkable advancements, primarily due to their capabilities in modeling the hidden relationships within text sequences. This innovation presents a unique opportunity in the field of life…

Genomics · Quantitative Biology 2024-12-25 Cong Li , Qingqing Long , Yuanchun Zhou , Meng Xiao

Gene expression is a cellular process that plays a fundamental role in human phenotypical variations and diseases. Despite advances of deep learning models for gene expression prediction, recent benchmarks have revealed their inability to…

Cell Behavior · Quantitative Biology 2024-10-04 Edouardo Honig , Huixin Zhan , Ying Nian Wu , Zijun Frank Zhang

GPT-3 and several other language models (LMs) can effectively address various natural language processing (NLP) tasks, including machine translation and text summarization. Recently, they have also been successfully employed in the business…

Artificial Intelligence · Computer Science 2023-04-17 Kiran Busch , Alexander Rochlitzer , Diana Sola , Henrik Leopold

Large language models (LLMs) have shown remarkable performance on many different Natural Language Processing (NLP) tasks. Prompt engineering plays a key role in adding more to the already existing abilities of LLMs to achieve significant…

Computation and Language · Computer Science 2024-07-25 Shubham Vatsal , Harsh Dubey

Large Language Models (LLMs) have become a cornerstone in Natural Language Processing (NLP), achieving impressive performance in text generation. Their token-level representations capture rich, human-aligned semantics. However, pooling…

Computation and Language · Computer Science 2025-09-25 Benedikt Roth , Stephan Rappensperger , Tianming Qiu , Hamza Imamović , Julian Wörmann , Hao Shen

We consider the protein sequence engineering problem, which aims to find protein sequences with high fitness levels, starting from a given wild-type sequence. Directed evolution has been a dominating paradigm in this field which has an…

Machine Learning · Computer Science 2025-01-20 Yinkai Wang , Jiaxing He , Yuanqi Du , Xiaohui Chen , Jianan Canal Li , Li-Ping Liu , Xiaolin Xu , Soha Hassoun

We explore the ability of large language models (LLMs) to act as speech recognition post-processors that perform rescoring and error correction. Our first focus is on instruction prompting to let LLMs perform these task without fine-tuning,…

Computation and Language · Computer Science 2024-01-29 Chao-Han Huck Yang , Yile Gu , Yi-Chieh Liu , Shalini Ghosh , Ivan Bulyko , Andreas Stolcke

This case study investigates the task of job classification in a real-world setting, where the goal is to determine whether an English-language job posting is appropriate for a graduate or entry-level position. We explore multiple…

Computation and Language · Computer Science 2023-04-19 Benjamin Clavié , Alexandru Ciceu , Frederick Naylor , Guillaume Soulié , Thomas Brightwell

This paper discusses the methods that we used for our submissions to the WMT 2023 Terminology Shared Task for German-to-English (DE-EN), English-to-Czech (EN-CS), and Chinese-to-English (ZH-EN) language pairs. The task aims to advance…

Computation and Language · Computer Science 2025-03-04 Yasmin Moslem , Gianfranco Romani , Mahdi Molaei , Rejwanul Haque , John D. Kelleher , Andy Way