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Supervised training of an automated medical image analysis system often requires a large amount of expert annotations that are hard to collect. Moreover, the proportions of data available across different classes may be highly imbalanced…

Computer Vision and Pattern Recognition · Computer Science 2019-12-10 Yuan Xue , Jiarong Ye , Rodney Long , Sameer Antani , Zhiyun Xue , Xiaolei Huang

Constrained decoding enables Language Models (LMs) to produce samples that provably satisfy hard constraints. However, existing constrained-decoding approaches often distort the underlying model distribution, a limitation that is especially…

Artificial Intelligence · Computer Science 2025-06-09 Emmanuel Anaya Gonzalez , Sairam Vaidya , Kanghee Park , Ruyi Ji , Taylor Berg-Kirkpatrick , Loris D'Antoni

Synthetic medical data which preserves privacy while maintaining utility can be used as an alternative to real medical data, which has privacy costs and resource constraints associated with it. At present, most models focus on generating…

Machine Learning · Computer Science 2019-11-28 Saloni Dash , Ritik Dutta , Isabelle Guyon , Adrien Pavao , Andrew Yale , Kristin P. Bennett

A plethora of protein language models have been released in recent years. Yet comparatively little work has addressed how to best sample from them to optimize desired biological properties. We fill this gap by proposing a flexible,…

Machine Learning · Computer Science 2026-05-08 Calvin McCarter , Nick Bhattacharya , Sebastian W. Ober , Hunter Elliott

Improving the accuracy and reliability of medical coding reduces clinician burnout and supports revenue cycle processes, freeing providers to focus more on patient care. However, automating the assignment of ICD-10-CM and CPT codes from…

Accurate prognosis of non-small cell lung cancer (NSCLC) patients undergoing immunotherapy is essential for personalized treatment planning, enabling informed patient decisions, and improving both treatment outcomes and quality of life.…

Computer Vision and Pattern Recognition · Computer Science 2025-08-22 Qilong Xing , Zikai Song , Bingxin Gong , Lian Yang , Junqing Yu , Wei Yang

The generation of synthetic clinical trial data offers a promising approach to mitigating privacy concerns and data accessibility limitations in medical research. However, ensuring that synthetic datasets maintain high fidelity, utility,…

Machine Learning · Computer Science 2025-12-16 Waldemar Hahn , Jan-Niklas Eckardt , Christoph Röllig , Martin Sedlmayr , Jan Moritz Middeke , Markus Wolfien

Large language models (LLMs) achieve strong performance across diverse tasks, largely driven by high-quality web data used in pre-training. However, recent studies indicate this data source is rapidly depleting. Synthetic data emerges as a…

Malignant brain tumors have become an aggressive and dangerous disease that leads to death worldwide.Multi-modal MRI data is crucial for accurate brain tumor segmentation, but missing modalities common in clinical practice can severely…

Methodology · Statistics 2025-07-11 Guoyan Liang , Qin Zhou , Jingyuan Chen , Bingcang Huang , Kai Chen , Lin Gu , Zhe Wang , Sai Wu , Chang Yao

Medicine is rife with high-stakes uncertainty. Doctors routinely make clinical judgments and decisions that juggle many fundamental unknowns, like predictions about what might be causing a patients' symptoms or decisions about what…

Multimodal (MM) learning is emerging as a promising paradigm in biomedical artificial intelligence (AI) applications, integrating complementary modality, which highlight different aspects of patient health. The scarcity of large…

Artificial Intelligence · Computer Science 2025-12-01 Niccolo Marini , Zhaohui Liang , Sivaramakrishnan Rajaraman , Zhiyun Xue , Sameer Antani

An important goal of self-supervised learning is to enable model pre-training to benefit from almost unlimited data. However, one method that has recently become popular, namely masked image modeling (MIM), is suspected to be unable to…

Computer Vision and Pattern Recognition · Computer Science 2022-06-10 Zhenda Xie , Zheng Zhang , Yue Cao , Yutong Lin , Yixuan Wei , Qi Dai , Han Hu

Synthetic data generation creates data based on real-world data using generative models. In health applications, generating high-quality data while maintaining fairness for sensitive attributes is essential for equitable outcomes. Existing…

Machine Learning · Computer Science 2025-06-25 Nitish Nagesh , Ziyu Wang , Amir M. Rahmani

Revealing hidden causal variables alongside the underlying causal mechanisms is essential to the development of science. Despite the progress in the past decades, existing practice in causal discovery (CD) heavily relies on high-quality…

Machine Learning · Computer Science 2025-10-14 Chenxi Liu , Yongqiang Chen , Tongliang Liu , Mingming Gong , James Cheng , Bo Han , Kun Zhang

Clinical risk prediction models often underperform in real-world settings due to poor calibration, limited transportability, and subgroup disparities. These challenges are amplified in high-dimensional multimodal cancer datasets…

Machine Learning · Computer Science 2026-02-26 Toktam Khatibi

In this work, we significantly enhance masked particle modeling (MPM), a self-supervised learning scheme for constructing highly expressive representations of unordered sets relevant to developing foundation models for high-energy physics.…

High Energy Physics - Phenomenology · Physics 2024-10-02 Matthew Leigh , Samuel Klein , François Charton , Tobias Golling , Lukas Heinrich , Michael Kagan , Inês Ochoa , Margarita Osadchy

Large Language Models (LLMs) hold immense potential for revolutionizing Customer Experience Management (CXM), particularly in contact center operations. However, evaluating their practical utility in complex operational environments is…

Machine Learning · Computer Science 2025-05-20 Raghav Garg , Kapil Sharma , Karan Gupta

The availability of real data from areas with high privacy requirements, such as the medical intervention space, is low and the acquisition legally complex. Therefore, this work presents a way to create a synthetic dataset for the medical…

Computer Vision and Pattern Recognition · Computer Science 2022-09-26 Patrick Schülein , Hannah Teufel , Ronja Vorpahl , Indira Emter , Yannick Bukschat , Marcus Pfister , Anke Siebert , Nils Rathmann , Steffen Diehl , Marcus Vetter

Balanced representation learning methods have been applied successfully to counterfactual inference from observational data. However, approaches that account for survival outcomes are relatively limited. Survival data are frequently…

Machine Learning · Statistics 2021-03-04 Paidamoyo Chapfuwa , Serge Assaad , Shuxi Zeng , Michael J. Pencina , Lawrence Carin , Ricardo Henao

Deep generative models and synthetic medical data have shown significant promise in addressing key challenges in healthcare, such as privacy concerns, data bias, and the scarcity of realistic datasets. While research in this area has grown…

Machine Learning · Computer Science 2025-02-05 Krishan Agyakari Raja Babu , Supriti Mulay , Om Prabhu , Mohanasankar Sivaprakasam