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Sharing genome data in a privacy-preserving way stands as a major bottleneck in front of the scientific progress promised by the big data era in genomics. A community-driven protocol named genomic data-sharing beacon protocol has been…

Cryptography and Security · Computer Science 2020-08-25 Kerem Ayoz , Erman Ayday , A. Ercument Cicek

Large genomic datasets are now created through numerous activities, including recreational genealogical investigations, biomedical research, and clinical care. At the same time, genomic data has become valuable for reuse beyond their…

Cryptography and Security · Computer Science 2021-12-28 Rajagopal Venkatesaramani , Zhiyu Wan , Bradley A. Malin , Yevgeniy Vorobeychik

Structured and unstructured data and facts about drugs, genes, protein, viruses, and their mechanism are spread across a huge number of scientific articles. These articles are a large-scale knowledge source and can have a huge impact on…

Artificial Intelligence · Computer Science 2022-10-13 Md. Rezaul Karim , Hussain Ali , Prinon Das , Mohamed Abdelwaheb , Stefan Decker

Generative Artificial Intelligence (GenAI) and communication networks are expected to have groundbreaking synergies for 6G. Connecting GenAI agents via a wireless network can potentially unleash the power of Collective Intelligence (CI) and…

Artificial Intelligence · Computer Science 2025-05-06 Hang Zou , Qiyang Zhao , Samson Lasaulce , Lina Bariah , Mehdi Bennis , Merouane Debbah

Efficient patient-doctor interaction is among the key factors for a successful disease diagnosis. During the conversation, the doctor could query complementary diagnostic information, such as the patient's symptoms, previous surgery, and…

Computation and Language · Computer Science 2024-10-08 Xueshen Li , Xinlong Hou , Nirupama Ravi , Ziyi Huang , Yu Gan

Knowledge models are fundamental to dialogue systems for enabling conversational interactions, which require handling domain-specific knowledge. Ensuring effective communication in information-providing conversations entails aligning user…

Computation and Language · Computer Science 2024-08-13 Phillip Schneider , Nektarios Machner , Kristiina Jokinen , Florian Matthes

Human genomic data carry unique information about an individual and offer unprecedented opportunities for healthcare. The clinical interpretations derived from large genomic datasets can greatly improve healthcare and pave the way for…

Cryptography and Security · Computer Science 2022-09-19 Mohammed Alghazwi , Fatih Turkmen , Joeri van der Velde , Dimka Karastoyanova

Novel technologies in genomics allow creating data in exascale dimension with relatively minor effort of human and laboratory and thus monetary resources compared to capabilities only a decade ago. While the availability of this data…

Distributed, Parallel, and Cluster Computing · Computer Science 2015-11-10 Sandra Gesing , Thomas Richard Connor , Ian Taylor

The capabilities of AI for biomedicine span a wide spectrum, from the atomic level, where it solves partial differential equations for quantum systems, to the molecular level, predicting chemical or protein structures, and further extending…

Computation and Language · Computer Science 2024-03-26 Zhenyu Bi , Sajib Acharjee Dip , Daniel Hajialigol , Sindhura Kommu , Hanwen Liu , Meng Lu , Xuan Wang

Rapid advancements in technology have led to an increased use of artificial intelligence (AI) technologies in medicine and bioinformatics research. In anticipation of this, the National Institutes of Health (NIH) assembled the Bridge to…

Other Quantitative Biology · Quantitative Biology 2025-12-15 Matthew Cannon , Wesley Goar , In-Hee Lee , James Stevenson , Amy Heiser , Nathan Sheffield , James Eddy , Monica Munoz-Torres , Sek Wong Kong , Alex H Wagner

Genomics methods have uncovered patterns in a range of biological systems, but obscure important aspects of cell behavior: the shape, relative locations of, movement of, and interactions between cells in space. Spatial technologies that…

Applications · Statistics 2023-10-17 Siddhartha G Jena , Archit Verma , Barbara E Engelhardt

Asking good questions in large-scale, open-domain conversational systems is quite significant yet rather untouched. This task, substantially different from traditional question generation, requires to question not only with various patterns…

Computation and Language · Computer Science 2018-05-15 Yansen Wang , Chenyi Liu , Minlie Huang , Liqiang Nie

Medical dialogue generation aims to generate responses according to a history of dialogue turns between doctors and patients. Unlike open-domain dialogue generation, this requires background knowledge specific to the medical domain.…

Computation and Language · Computer Science 2023-03-16 Chen Tang , Hongbo Zhang , Tyler Loakman , Chenghua Lin , Frank Guerin

Genetic dispositions play a major role in individual disease risk and treatment response. Genomic medicine, in which medical decisions are refined by genetic information of particular patients, is becoming increasingly important. Here we…

Other Computer Science · Computer Science 2011-09-30 Matthias Samwald , Holger Stenzhorn , Michel Dumontier , M. Scott Marshall , Joanne Luciano , Klaus-Peter Adlassnig

Data commons collate data with cloud computing infrastructure and commonly used software services, tools and applications to create biomedical resources for the large-scale management, analysis, harmonization, and sharing of biomedical…

Genomics · Quantitative Biology 2018-12-27 Robert L. Grossman

Creating end-to-end bioinformatics workflows requires diverse domain expertise, which poses challenges for both junior and senior researchers as it demands a deep understanding of both genomics concepts and computational techniques. While…

In this work, we develop an intelligent user interface that allows users to enter biomedical queries in a natural language, and that presents the answers (possibly with explanations if requested) in a natural language. We develop a rule…

Artificial Intelligence · Computer Science 2010-12-10 Halit Erdogan , Umut Oztok , Yelda Erdem , Esra Erdem

Large language models (LLMs) are having transformative impacts across a wide range of scientific fields, particularly in the biomedical sciences. Just as the goal of Natural Language Processing is to understand sequences of words, a major…

Genomics · Quantitative Biology 2024-09-24 Gonzalo Benegas , Chengzhong Ye , Carlos Albors , Jianan Canal Li , Yun S. Song

Artificial Intelligence (AI) incorporating genetic and medical information have been applied in disease risk prediction, unveiling disease mechanism, and advancing therapeutics. However, AI training relies on highly sensitive and private…

Since the completion of the human genome sequencing project in 2001, significant progress has been made in areas such as gene regulation editing and protein structure prediction. However, given the vast amount of genomic data, the segments…

Other Quantitative Biology · Quantitative Biology 2025-01-29 Wang Liang
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