Rapid advancements in technology have led to an increased use of artificial intelligence (AI) technologies in medicine and bioinformatics research. In anticipation of this, the National Institutes of Health (NIH) assembled the Bridge to Artificial Intelligence (Bridge2AI) consortium to coordinate development of AI-ready datasets that can be leveraged by AI models to address grand challenges in human health and disease. The widespread availability of genome sequencing technologies for biomedical research presents a key data type for informing AI models, necessitating that genomics data sets are AI-ready. To this end, the Genomic Information Standards Team (GIST) of the Bridge2AI Standards Working Group has documented a set of recommendations for maintaining AI-ready genomics datasets. In this report, we describe recommendations for the collection, storage, identification, and proper use of genomics datasets to enable them to be considered AI-ready and thus drive new insights in medicine through AI and machine learning applications.
@article{arxiv.2512.11519,
title = {Bridge2AI Recommendations for AI-Ready Genomic Data},
author = {Matthew Cannon and Wesley Goar and In-Hee Lee and James Stevenson and Amy Heiser and Nathan Sheffield and James Eddy and Monica Munoz-Torres and Sek Wong Kong and Alex H Wagner},
journal= {arXiv preprint arXiv:2512.11519},
year = {2025}
}