English
Related papers

Related papers: Predicting time-varying flux and balance in metabo…

200 papers

We develop a data-driven deep neural operator framework to approximate multiple output states for a diesel engine and generate real-time predictions with reasonable accuracy. As emission norms become more stringent, the need for fast and…

Signal Processing · Electrical Eng. & Systems 2025-01-16 Varun Kumar , Somdatta Goswami , Daniel J. Smith , George Em Karniadakis

Many aspects of graphs have been studied in depth. However, forecasting the structure of a graph at future time steps incorporating unseen, new nodes and edges has not gained much attention. In this paper, we present such an approach. Using…

Machine Learning · Computer Science 2024-07-26 Sevvandi Kandanaarachchi , Ziqi Xu , Stefan Westerlund

Current mathematical frameworks for predicting the flux state and macromolecular composition of the cell do not rely on thermodynamic constraints to determine the spontaneous direction of reactions. These predictions may be biologically…

Optimization and Control · Mathematics 2020-08-14 Amir Akbari , Bernhard O. Palsson

Despite its widespread use in materials science, conventional molecular dynamics (MD) simulations are severely constrained by timescale limitations. To address this shortcoming, we propose an empirical formulation of accelerated MD method,…

Materials Science · Physics 2025-12-10 Liang Wan , Qingsong Mei , Haowen Liu , Huafeng Zhang , Jun-Ping Du , Shigenobu Ogata , Wen Tong Geng

The manifold hypothesis suggests that high-dimensional neural time series lie on a low-dimensional manifold shaped by simpler underlying dynamics. To uncover this structure, latent dynamical variable models such as state-space models,…

Machine Learning · Computer Science 2025-07-30 Pedram Rajaei , Maryam Ostadsharif Memar , Navid Ziaei , Behzad Nazari , Ali Yousefi

Model reduction for fluid flow simulation continues to be of great interest across a number of scientific and engineering fields. In a previous work [arXiv:2104.13962], we explored the use of Neural Ordinary Differential Equations (NODE) as…

Machine Learning · Computer Science 2021-07-07 Sourav Dutta , Peter Rivera-Casillas , Orie M. Cecil , Matthew W. Farthing , Emma Perracchione , Mario Putti

Given the critical role played by natural gas in providing electricity, heat, and other essential services, better models are needed to understand the dynamics of natural gas networks during extreme events. This paper aims at establishing…

Systems and Control · Electrical Eng. & Systems 2021-01-01 Samuel Chevalier , Dan Wu

As deep neural networks (DNNs) are being applied to a wide range of edge intelligent applications, it is critical for edge inference platforms to have both high-throughput and low-latency at the same time. Such edge platforms with multiple…

Machine Learning · Computer Science 2023-05-03 Ziyang Zhang , Huan Li , Yang Zhao , Changyao Lin , Jie Liu

Discontinuities and delayed terms are encountered in the governing equations of a large class of problems ranging from physics and engineering to medicine and economics. These systems cannot be properly modelled and simulated with standard…

Artificial Intelligence · Computer Science 2024-09-27 Thibault Monsel , Onofrio Semeraro , Lionel Mathelin , Guillaume Charpiat

Irregular sampling intervals and missing values in real-world time series data present challenges for conventional methods that assume consistent intervals and complete data. Neural Ordinary Differential Equations (Neural ODEs) offer an…

Machine Learning · Computer Science 2025-01-28 YongKyung Oh , Dong-Young Lim , Sungil Kim

We propose a novel approach to the estimation of multiple Graphical Models to analyse temporal patterns of association among a set of metabolites over different groups of patients. Our motivating application is the Southall And Brent…

Strongly nonlinear flows, which commonly arise in geophysical and engineering turbulence, are characterized by persistent and intermittent energy transfer between various spatial and temporal scales. These systems are difficult to model and…

Dynamical Systems · Mathematics 2022-01-25 Hassan Arbabi , Themistoklis Sapsis

The performance of flow matching and diffusion models can be greatly improved at inference time using reward alignment algorithms, yet efficiency remains a major limitation. While several algorithms were proposed, we demonstrate that a…

Machine Learning · Computer Science 2026-02-12 Peter Holderrieth , Uriel Singer , Tommi Jaakkola , Ricky T. Q. Chen , Yaron Lipman , Brian Karrer

Smoothed analysis is a framework suggested for mediating gaps between worst-case and average-case complexities. In a recent work, Dinitz et al.~[Distributed Computing, 2018] suggested to use smoothed analysis in order to study dynamic…

Distributed, Parallel, and Cluster Computing · Computer Science 2020-09-29 Uri Meir , Ami Paz , Gregory Schwartzman

This work proposes a new machine learning (ML)-based paradigm aiming to enhance the computational efficiency of non-equilibrium reacting flow simulations while ensuring compliance with the underlying physics. The framework combines…

Computational Physics · Physics 2023-09-25 Ivan Zanardi , Simone Venturi , Marco Panesi

Neural operator surrogates for time-dependent partial differential equations (PDEs) conventionally employ autoregressive prediction schemes, which accumulate error over long rollouts and require uniform temporal discretization. We introduce…

Machine Learning · Computer Science 2025-12-08 Xianglong Hou , Xinquan Huang , Paris Perdikaris

The physical world is governed by the laws of physics, often represented in form of nonlinear partial differential equations (PDEs). Unfortunately, solution of PDEs is non-trivial and often involves significant computational time. With…

Machine Learning · Statistics 2021-08-25 Yash Kumar , Souvik Chakraborty

The dynamics of systems biological processes are usually modeled by a system of ordinary differential equations (ODEs) with many unknown parameters that need to be inferred from noisy and sparse measurements. Here, we introduce…

Quantitative Methods · Quantitative Biology 2022-02-04 Mitchell Daneker , Zhen Zhang , George Em Karniadakis , Lu Lu

Accurate quantification of intracellular metabolic fluxes is central to systems biology and biotechnology. Flux estimation relies on biochemical network models, with $^{13}$C metabolic flux analysis (MFA) being the state-of-the-art…

Quantitative Methods · Quantitative Biology 2026-05-26 Johann F. Jadebeck , Anton Stratmann , Martin Beyß , Katharina Nöh

Designing network parameters that can effectively represent complex networks is of significant importance for the analysis of time-varying complex networks. This paper introduces a novel thermodynamic framework for analyzing complex…

Quantitative Methods · Quantitative Biology 2024-09-04 Dayu Qin , Yuzhe Chen , Ercan Engin Kuruoglu