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Structure-Based Drug Design (SBDD) is crucial for identifying bioactive molecules. Recent deep generative models are faced with challenges in geometric structure modeling. A major bottleneck lies in the twisted probability path of…

Biomolecules · Quantitative Biology 2025-06-06 Keyue Qiu , Yuxuan Song , Zhehuan Fan , Peidong Liu , Zhe Zhang , Mingyue Zheng , Hao Zhou , Wei-Ying Ma

Modeling the dynamics from sparsely time-resolved snapshot data is crucial for understanding complex cellular processes and behavior. Existing methods leverage optimal transport, Schr\"odinger bridge theory, or their variants to…

Machine Learning · Computer Science 2025-10-28 Zhenyi Zhang , Zihan Wang , Yuhao Sun , Tiejun Li , Peijie Zhou

Neural differential equations predict the derivative of a stochastic process. This allows irregular forecasting with arbitrary time-steps. However, the expressive temporal flexibility often comes with a high sensitivity to noise. In…

Machine Learning · Computer Science 2023-02-07 Stav Belogolovsky , Ido Greenberg , Danny Eitan , Shie Mannor

When learning dynamical systems from data, embedding physical structure can constrain the solution space and improve generalization, but many physics-informed models assume access to the full system state. This limits their use in partially…

Machine Learning · Computer Science 2026-05-25 Sunniva Meltzer , Sølve Eidnes , Alexander Johannes Stasik

Predicting nutrient transport and salinity distribution is crucial for mitigating climate-related threats to agromaritime systems. Traditional PDE-based models can capture the physics of nutrient dispersion, salinity and water quality.…

Numerical Analysis · Mathematics 2026-04-24 Muhammad Ilyas

Synchronous Data Flow (SDF) model is widely used for specifying signal processing or streaming applications. Since modern embedded applications become more complex with dynamic behavior changes at run-time, several extensions of the SDF…

Other Computer Science · Computer Science 2017-10-20 Hanwoong Jung , Hyunok Oh , Soonhoi Ha

We present a new paradigm for Neural ODE algorithms, called ODEtoODE, where time-dependent parameters of the main flow evolve according to a matrix flow on the orthogonal group O(d). This nested system of two flows, where the parameter-flow…

Astronomical time series from large-scale surveys like LSST are often irregularly sampled and incomplete, posing challenges for classification and anomaly detection. We introduce a new framework based on Neural Stochastic Delay Differential…

Machine Learning · Computer Science 2026-04-03 YongKyung Oh , Seungsu Kam , Dong-Young Lim , Sungil Kim

The MRI-derived brain network serves as a pivotal instrument in elucidating both the structural and functional aspects of the brain, encompassing the ramifications of diseases and developmental processes. However, prevailing methodologies,…

Machine Learning · Computer Science 2024-05-24 Haoteng Tang , Guodong Liu , Siyuan Dai , Kai Ye , Kun Zhao , Wenlu Wang , Carl Yang , Lifang He , Alex Leow , Paul Thompson , Heng Huang , Liang Zhan

Under a smart grid paradigm, there has been an increase in sensor installations to enhance situational awareness. The measurements from these sensors can be leveraged for real-time monitoring, control, and protection. However, these…

Systems and Control · Electrical Eng. & Systems 2022-11-09 Shweta Dahale , Sai Munikoti , Balasubramaniam Natarajan , Rui Yang

Embodied trajectories, such as the executable motion sequences of robotic manipulators, underwater vehicles, and mobile robots, are a fundamental output of embodied AI. Modern generative models often treat them as a dense, monolithic signal…

Robotics · Computer Science 2026-05-25 Yan Tang , Yuanbo Tang , Tingyu Cao , Shaolun Huang , Yang Li

To model time series accurately is important within a wide range of fields. As the world is generally too complex to be modelled exactly, it is often meaningful to assess the probability of a dynamical system to be in a specific state. This…

Machine Learning · Computer Science 2023-03-16 Mari Dahl Eggen , Alise Danielle Midtfjord

Biological neural networks (BNNs) have been established as a powerful and adaptive substrate that offer the potential for incredibly energy and data efficient information processing with distinct learning mechanisms. Yet a core challenge to…

Graph-based spatio-temporal neural networks are effective to model the spatial dependency among discrete points sampled irregularly from unstructured grids, thanks to the great expressiveness of graph neural networks. However, these models…

Machine Learning · Computer Science 2022-04-22 Haitao Lin , Guojiang Zhao , Lirong Wu , Stan Z. Li

Neural differential equations are a promising new member in the neural network family. They show the potential of differential equations for time series data analysis. In this paper, the strength of the ordinary differential equation (ODE)…

Machine Learning · Computer Science 2020-05-21 Mansura Habiba , Barak A. Pearlmutter

In real-time systems, the application's behavior has to be predictable at compile-time to guarantee timing constraints. However, modern streaming applications which exhibit adaptive behavior due to mode switching at run-time, may degrade…

Distributed, Parallel, and Cluster Computing · Computer Science 2018-07-16 Jiali Teddy Zhai , Sobhan Niknam , Todor Stefanov

Neural ODEs (NODEs) have emerged as powerful tools for modeling time series data, offering the flexibility to adapt to varying input scales and capture complex dynamics. However, they face significant challenges: first, their reliance on…

Machine Learning · Computer Science 2025-10-07 Muhao Guo , Yang Weng

We present a falsification framework that integrates learned surrogate dynamics with optimal control to efficiently generate counterexamples for cyber-physical systems specified in signal temporal logic (STL). The unknown system dynamics…

Systems and Control · Electrical Eng. & Systems 2026-02-03 Lasse Kötz , Jonas Sjöberg , Knut Åkesson

We propose a statistical-stochastic surrogate modeling approach to predict the response of the mean and variance statistics under various initial conditions and external forcing perturbations. The proposed modeling framework extends the…

Data Analysis, Statistics and Probability · Physics 2023-04-07 Di Qi , John Harlim

Neurons exhibit intricate geometries within their neurite networks, which play a crucial role in processes such as signaling and nutrient transport. Accurate simulation of material transport in the networks is essential for understanding…

Machine Learning · Computer Science 2025-07-16 Tsung Yeh Hsieh , Yongjie Jessica Zhang